Conference: 4th Penn State Bioinorganic Workshop and the 4th "Frontiers in Metallobiochemistry" Symposium to be held at Penn State University; June 2 - June 10, 2016

会议：第四届宾夕法尼亚州立大学生物无机研讨会和第四届“金属生物化学前沿”研讨会将在宾夕法尼亚州立大学举行；

• 批准号: 1641159
• 负责人: Carsten Krebs
• 金额: $ 1万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1641159&HistoricalAwards=false
• 关键词: Conference; 4th; Penn; State; Bioinorganic

Enzymes containing transition metal ions in their active sites catalyze some of the most important and difficult chemical reactions in biology, including the reduction of nitrogen to ammonia, the oxidation of water to oxygen in photosynthesis, and the stereospecific functionalization of unactivated carbon-hydrogen bonds. The area of bioinorganic chemistry aims to understand the role that metal ions play in bio-catalytic processes and use this understanding to enable the design of new bio-inspired catalysts. The efforts are important to society, because they may facilitate, for example, the generation of renewable energy (e.g. solar energy conversion and bioproduction of renewable fuels) to power the planet. It may also facilitate the production of cheaper fertilizers for agriculture. The field of bioinorganic chemistry is diverse and includes a wide variety of scientific disciplines, including genetics, molecular biology, biochemistry, biophysics, bioinformatics, analytical chemistry, and physical chemistry. Many different experimental techniques and theoretical methods are combined to study the formation, function and regulation of the metal cofactors, as well as the mechanism of these metal-containing enzymes. For these reasons, research in this area is generally highly collaborative. This workshop will train students, postdoctoral scholars and faculty members from primarily undergraduate institutions in the area of bioinorganic chemistry, setting the stage for future discoveries in this exciting field. With this award, the Molecular Biophysics Program in the Molecular and Cellular Biosciences Division and the Chemistry of Life Processes Program in the Chemistry Division is co-funding a biennial training workshop, which is led by Prof. Carsten Krebs and colleagues at the Department of Chemistry at The Pennsylvania State University. The 2016 workshop provides training for approximately 150 participants and encompasses (i) 17 lectures by faculty experts in the field in their area of specialty, (ii) hands-on training in 21 different methods offered to small groups of up to 6 participants in 2-hour time-blocks (repeated up to 12 times) and taught by 70 student/postdoc/faculty experts in bioinorganic methods and (iii) research presentations in the form of posters and 12 talks by selected students and postdoctoral scholars. This workshop will uniquely train the next generation of researchers in the field of bioinorganic chemistry.

在其活性位点中含有过渡金属离子的酶催化生物学中一些最重要和最困难的化学反应，包括氮还原为氨，光合作用中水氧化为氧，以及未活化的碳-氢键的立体特异性功能化。 生物无机化学领域旨在了解金属离子在生物催化过程中的作用，并利用这种理解来设计新的生物启发催化剂。 这些努力对社会很重要，因为它们可以促进可再生能源的产生（例如太阳能转换和可再生燃料的生物生产），为地球提供动力。 它还可以促进生产更便宜的农业肥料。 生物无机化学领域多种多样，包括多种科学学科，包括遗传学、分子生物学、生物化学、生物物理学、生物信息学、分析化学和物理化学。 许多不同的实验技术和理论方法相结合，研究金属辅因子的形成，功能和调节，以及这些含金属酶的机制。 由于这些原因，这一领域的研究通常是高度合作的。 本次研讨会将培训学生，博士后学者和教师主要是本科院校在生物无机化学领域，在这个令人兴奋的领域为未来的发现奠定了基础。有了这个奖项，分子和细胞生物科学部的分子生物物理学项目和化学部的生命过程化学项目共同资助了一个两年一度的培训研讨会，该研讨会由宾夕法尼亚州立大学化学系的Carsten Krebs教授和同事领导。 2016年的研讨会为大约150名参与者提供培训，包括（i）17个讲座，由教师专家在他们的专业领域，㈡在2小时的时间段内，向最多6人的小组提供21种不同方法的实践培训（重复多达12次），并由70名学生/博士后/教师生物无机方法专家授课，（iii）以海报形式进行研究演示，并由选定的学生和博士后学者进行12次会谈。 该研讨会将独特地培养生物无机化学领域的下一代研究人员。