Support for the 3rd Penn State Bioinorganic Workshop and the 3rd "Frontiers in Metallobiochemistry" Symposium, May 28 - June 4, 2014

支持第三届宾夕法尼亚州立大学生物无机研讨会和第三届“金属生物化学前沿”研讨会，2014年5月28日至6月4日

• 批准号: 1441882
• 负责人: Carsten Krebs
• 金额: $ 1万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-15 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1441882&HistoricalAwards=false
• 关键词: Support; 3rd; Penn; State; Bioinorganic

Enzymes containing transition metal ions in their active sites catalyze some of the most difficult chemical reactions in biology, including as the oxidation of water to dioxygen in photosynthesis, the reduction of dinitrogen to ammonia, and the stereospecific functionalization of unactivated carbon-hydrogen bonds. Remarkably, these reactions proceed under ambient conditions. The area of bioinorganic chemistry aims to (i) understand these processes in detail and (ii) use this understanding to enable design of new bio-inspired catalysts. The efforts are important to society, because they may enable, for example, the generation of renewable energy to power the planet and cheaper fertilizers for agriculture. The field of bioinorganic chemistry is diverse and includes a wide variety of scientific disciplines, including genetics, molecular biology, biochemistry, bioinformatics, analytical chemistry, and physical chemistry. Many different experimental techniques (e.g. reaction kinetics, a wide variety of spectroscopies, X-ray crystallography, and mass spectrometry) and theoretical methods (e.g. electronic structure calculations and bioinformatics methods) are combined to study the reaction mechanisms of enzymes containing metals. For these reasons, research in this area is generally highly collaborative. This workshop will train students and postdoctoral scholars in the area of bioinorganic chemistry. The training of students, postdoctoral scholars and even faculty has a long tradition in this research field and is an important prerequisite for a productive collaborative environment. With this award, the Chemistry of Life Processes Program in the Chemistry Division is funding a biennial training workshop, which is led by Prof. Carsten Krebs and colleagues at the Department of Chemistry at The Pennsylvania State University. The 2014 workshop provides training for approximately 150 participants and encompasses (i) 16 lectures by faculty experts in the field in their area of specialty and (ii) hands-on training in 21 different methods offered to small groups of up to 6 participants in 2-hour time-blocks (repeated up to 12 times) and taught by 70 student/postdoc/faculty experts in bioinorganic methods. This workshop will uniquely train the next generation of researchers in the field of bioinorganic chemistry. This year's workshop is even larger than the 2012 workshop, which was received with broad enthusiasm by the scientific field.

含有过渡金属离子的活性位点中含有过渡金属离子的酶催化了生物学中一些最困难的化学反应，包括作为光合作用中水对二恶英的氧化，二氮对氨的还原以及未激活的碳 - 碳氧键的立体功能化。值得注意的是，这些反应在环境条件下进行。生物无机化学领域的目的是（i）详细了解这些过程，（ii）使用此理解来设计新的生物启发的催化剂。努力对社会很重要，因为它们可以使能够产生可再生能源来为行星和更便宜的农业施肥提供动力。生物无机化学领域是多种多样的，包括各种科学学科，包括遗传学，分子生物学，生物化学，生物信息学，分析化学和物理化学。将许多不同的实验技术（例如反应动力学，多种光谱，X射线晶体学和质谱法）和理论方法（例如电子结构计算和生物信息学方法）合并以研究含有金属的酶的反应机制。由于这些原因，该领域的研究通常是高度协作的。该研讨会将在生物无机化学领域培训学生和博士后学者。对学生，博士后学者甚至教师的培训在这个研究领域具有悠久的传统，并且是生产性协作环境的重要先决条件。通过该奖项，化学部门的化学过程计划正在为宾夕法尼亚州立大学化学系的Carsten Krebs及其同事教授领导，这是一项两年一次的培训研讨会。 2014年的研讨会为在特殊领域的该领域的教师专家和（ii）21种不同方法的动手培训提供了大约150名参与者和包容的培训（i）16个讲座，并为211个不同的培训提供了21种不同的方法，可为2小时的时间障碍（重复12次），并由70个学生/后夫人/夫妻教师教授，并在Bio persects中教授。该研讨会将独特地培训生物促进化学领域的下一代研究人员。今年的研讨会比2012年的研讨会还要大，该研讨会受到科学领域充满热情的热情。