Abnormal reorganization of prefrontal-hippocampal networks during juvenile development and resulting cognitive impairment in mental illness (B05)

青少年发育过程中前额叶-海马网络的异常重组以及由此导致的精神疾病认知障碍（B05）

• 批准号: 207153060
• 金额: --
• 依托单位: Institut für Entwicklungsneurophysiologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/207153060?language=en
• 关键词: Abnormal; reorganization; prefrontal; hippocampal; networks

Prefrontal-hippocampal dysfunction is considered as main cause of cognitive deficits in mental disorders, yet its ontogeny and mechanisms throughout life are still largely unknown. Using mouse models that mimic the etiology and symptoms of schizophrenia, we showed during the first two funding periods that, shortly after birth, the long-range coupling between prefrontal cortex and hippocampus is reduced due to structural and functional deficits of specific neuronal populations. Preliminary data identified juvenile age as an additional period of high vulnerability for disease. Here, we will elucidate the cellular substrate of juvenile prefrontal-hippocampal miswiring leading to poorer cognitive performance and identify electrophysiological markers of dysfunction common to mice and prodromal humans.

额叶前海马功能障碍被认为是精神疾病认知功能障碍的主要原因，但其个体发生和终生机制仍不清楚。使用模拟精神分裂症病因和症状的小鼠模型，我们在前两个资助期内发现，出生后不久，由于特定神经元群体的结构和功能缺陷，前额叶皮层和海马之间的长程耦合减少。初步数据表明，青少年时期是另一个易受疾病影响的时期。在这里，我们将阐明青少年前额叶-海马布线错误导致认知能力较差的细胞基质，并确定小鼠和前驱期人类常见的功能障碍的电生理标志物。