Prefrontal cortical circuit reorganization during immediate memory consolidation

即时记忆巩固过程中前额皮质回路重组

• 批准号: 10824532
• 负责人: Heath Larsson Robinson
• 金额: $ 6.91万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2027-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10824532
• 关键词: Address; Behavior; Behavioral; Brain region; Communication; Computer Analysis; Control Groups; Electrophysiology (science); Event; Evolution; Fiber Optics; Hippocampus; Impairment; Implant; Interneurons; Learning; Life; Light; Memory; Mission; Modification; Monitor; Mus; National Institute of Mental Health; Neurons; Output; Parvalbumins; Pattern; Performance; Physiological; Play; Prefrontal Cortex; Process; Property; Pyramidal Cells; Research Project Grants; Role; Short-Term Memory; Silicon; Structure; Synaptic plasticity; System; Testing; Time; Transgenic Mice; Tungsten; Work; cell type; cognitive function; educational atmosphere; experience; experimental study; in vivo; insight; long term memory; memory consolidation; memory encoding; memory process; memory recall; memory retrieval; neural; neurophysiology; optical fiber; optogenetics; spatial memory

PROJECT SUMMARY Learning and memory are fundamental cognitive functions that allow us to learn from the environment around us. Memory is the ability to store and recall information essential to everyday life. An indispensable property of memory is its stable storage, allowing for the recall of memories over extended periods of time. Yet the physiological mechanisms underlying the stable storage of memories for such a long-lasting time remain to be elucidated. Memory formation involves two stages, encoding, and consolidation. After encoding, the consolidation process solidifies these neuronal traces into long-lasting memories. Consolidation is a progressive process, starting with immediate consolidation that, over time, becomes long-term consolidation. The hippocampus (HPC) is a brain region fundamental to memory formation and immediate consolidation. As consolidation continues, the HPC offloads memories to the cortex, eventually becoming independent of the HPC. The HPC consolidation of memories involves a highly synchronous network event called a sharp-wave ripple (SWR). During SWRs, memory traces that represent a particular experience are replayed in a compressed manner, which is thought to consolidate these neuronal representations through synaptic plasticity. Yet, it is unknown how information from the HPC is transferred to the cortex during SWRs during immediate consolidation. A cortical region also involved in memory is the prefrontal cortex (PFC). Both the HPC and PFC are involved in spatial memory, making it an ideal behavior to investigate the transfer of HPC information to the PFC during immediate consolidation. The respective contribution of SWRs and local cortical circuit dynamics for immediate memory consolidation remains unknown. Furthermore, the circuit and cellular changes during immediate consolidation are not fully understood. This proposal targets these exact questions by 1) directly testing whether SWRs transfer information to the PFC necessary for immediate consolidation; 2) identifying the PFC neuronal assembly modifications during SWRs underlying immediate consolidation; and 3) elucidating the local PFC circuitry mechanisms that regulate these neuronal assembly changes during immediate consolidation. The aims of this proposal will directly test whether communication between HPC and PFC that occurs during SWRs is crucial for immediate memory consolidation and how local processes in the PFC evolve during memory consolidation. This work aligns with NIMH’s mission to understand the mechanisms of learning and memory at a system level by investigating the interactions between brain regions that might underlie these functions.

项目摘要 学习和记忆是基本的认知功能，使我们能够从周围的环境中学习。 我们记忆是储存和回忆日常生活中必不可少的信息的能力。不可或缺的财产 记忆是其稳定的存储，允许在较长的时间内回忆记忆。然而 记忆能长期稳定储存的生理机制仍有待进一步研究。 阐明。记忆的形成包括两个阶段：编码和巩固。编码后， 巩固过程将这些神经元痕迹巩固为持久的记忆。合并是一个 这是一个渐进的过程，从即时巩固开始，随着时间的推移，成为长期巩固。 海马体（HPC）是记忆形成和即时巩固的基础脑区。作为 合并继续进行，HPC将内存卸载到皮层，最终变得独立于大脑皮层。 HPC。HPC的内存整合涉及到一种称为sharp-wave的高度同步的网络事件 涟漪（SWR）。在SWR期间，代表特定经历的记忆痕迹在一个特定的时间段中重放。 压缩的方式，这被认为是巩固这些神经元代表通过突触 可塑性然而，尚不清楚在SWRs期间来自HPC的信息如何被传递到皮层。 立即巩固。前额叶皮层（PFC）也参与记忆。两者 HPC和PFC参与了空间记忆，因此研究HPC的迁移是一个理想的行为 在即时整合期间向PFC提供信息。SWRs和局部皮层的各自贡献 即时记忆巩固的电路动力学仍然是未知的。此外，电路和蜂窝 在立即合并期间的变化没有得到充分理解。这项建议针对的正是这些问题 通过1）直接测试SWR是否将信息传输到PFC，以便立即整合; 2） 识别在作为即刻巩固基础的SWR期间PFC神经元组装修饰;以及3） 阐明了调节这些神经元组装变化的局部PFC电路机制， 立即巩固。本提案的目的将直接测试HPC与 在SWR期间发生的PFC对于即时记忆巩固以及局部过程中的局部过程是至关重要的。 PFC在记忆巩固过程中进化。这项工作与NIMH的使命一致， 通过研究大脑区域之间的相互作用，在系统水平上研究学习和记忆机制 这些功能的基础