Reorganization of cortical memory ensembles across time
皮质记忆群随时间的重组
基本信息
- 批准号:10680332
- 负责人:
- 金额:$ 7.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-06-01 至 2026-11-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAgeAnatomyAnxiety DisordersAreaAuditoryAxonBehaviorBehavior ControlBehavioralBrainBrain MappingCalciumCellsCouplingCuesDataDiseaseEventFoundationsFreezingFrightFunctional disorderFutureGene ExpressionGoalsHeadImageImmediate-Early GenesLabelLightLinkMapsMedialMediatingMemoryMentorsMethodsMicroscopeModelingNational Institute of Mental HealthNatureNeuronsOutputPatternPilot ProjectsPopulationPost-Traumatic Stress DisordersPrefrontal CortexProcessPublishingResearchResistanceRetrievalRoleTestingTimeTissuesTraumaViral PhysiologyWorkassociation cortexcareercell typeconditioned feardesigneffective interventionemotional experienceexperienceexperimental studyfear memorygenetic approachimprovedinsightlong term memorymemory recallmemory retrievalneuralneural circuitnoveloptogeneticspreventrecruitsymposiumtherapeutic targettimelinevirus genetics
项目摘要
Project Summary
Memory of a single event can last a lifetime. Certain experiences can guide behavior minutes, months,
and years after the event has transpired. For this to happen, the brain must encode the relevant information
from the event, retain it for an indeterminate amount of time, then retrieve that memory when given appropriate
cues. Previous work has shown that retrieval of a fearful experience is behaviorally similar across recent and
remote retrieval times of a memory, yet the neural circuits mediating that memory are importantly different
across the memory timeline. In short, behavior remains stable while neural activity is dynamic. Evidence
suggests that memories are reorganized across time – increasingly involve a distributed cortical network.
Although we have identified several independent cortical regions that participate in remote memory, our
understanding of how they interact at the and the nature of these changes is lacking My preliminary data
indicates that an uninvestigated medial prefrontal cortex (mPFC) projection coordinates remote but not recent
memory via projections to association cortex. Further exploration is needed to determine the specific activity
patterns in these circuits during memory retrieval over time. These discoveries would reveal fundamental
principles by which the brain organizes and retrieves salient experiences across time.
The overall goal of this proposal is to investigate the cell-type specific changes that occur in
mPFC ensembles as fear memories reorganize from recent to remote and to determine the nature of
this reorganization. Based on published work from my mentor and my preliminary findings, my project will
focus on the connection between mPFC and auditory association areas. To address these questions, I will use
circuit-specific, optogenetic approaches to establish necessity and sufficiency of a mPFC–cortical association
circuit for remote memory. This will address the functional role of these mPFC projection neurons. I will then
use freely-moving calcium imaging to record the activity of these cells at both recent and remote memory
timepoints in order to examine how these mPFC neurons encode and behavior and task variables across
memory timepoints. Finally, with a combined viral-genetic approach, I will label activity-dependent ensembles
while employing whole-brain circuit mapping to understand the anatomical relationship between recent and
remote ensembles and their downstream connections. Together, these aims will reveal novel insights into the
time-dependent changes in memory organization and enhance our understanding of mPFC function in
organizing cortical networks, potentially identifying improved circuits to target for treatment of fear disorders
(e.g. Post Traumatic Stress Disorder).
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Zachary E Zeidler其他文献
Zachary E Zeidler的其他文献
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