MRI: Acquisition of a High Resolution Cryo Scanning Electron Microscope System

MRI：获取高分辨率冷冻扫描电子显微镜系统

• 批准号: 1229263
• 负责人: Lorraine Francis
• 金额: $ 63.88万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1229263&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Cryo; Scanning

This MRI grant supports the purchase of a new high resolution field emission scanning electron microscope (cryoSEM) with a cryostage and advanced features, including x-ray chemical analysis, and a versatile cryospecimen preparation and transfer system. This new cryoSEM system will be used in a wide variety of research projects to produce a more in depth and realistic understanding of the micro- and nanostructure, chemical composition and structural development of complex samples that are impossible to image in an ordinary, room temperature SEM. The features of the cryoSEM and the specimen preparation and handling system facilitate a variety of research projects that demand high resolution imaging with the option of chemical analysis and with precise control over the cryospecimen preparation and handling. Some example research projects include: microstructure development in liquid applied coatings, structure of ordered porous materials used as electrodes, nanostructure of complex, block copolymer-based hydrogels that are used drug delivery materials and the structure of hydrated collagen- and fibrin-based tissue equivalents. The research enabled by the cryoSEM facility will have broader impacts across a variety of fields, including coating processing, colloidal science, porous materials, block copolymers, collagen-based tissue equivalents, biofilms, geomagnetism, and emulsion science. The cryoSEM will provide results that could not be achieved by other means and will impact not only on the scientific understanding but also on the engineering of new materials and devices. The results will be disseminated in publications and presentations, including presentations to industry through the University of Minnesota's Industrial Partnership for Research in Interfacial and Materials Engineering. The new cryoSEM system will also impact the research training and education of students at various levels, from graduate students down to middle school students, through seminars, workshops and demonstrations.

该MRI补助金支持购买新的高分辨率场发射扫描电子显微镜（cryoSEM），该显微镜具有冷冻台和先进功能，包括X射线化学分析以及多功能冷冻标本制备和转移系统。这种新的cryoSEM系统将用于各种各样的研究项目，以更深入和真实地了解复杂样品的微观和纳米结构，化学成分和结构发展，这些样品在普通的室温SEM中无法成像。 cryoSEM和样品制备及处理系统的功能有助于各种需要高分辨率成像的研究项目，并可选择化学分析以及对冷冻样品制备和处理进行精确控制。 一些示例研究项目包括：液体应用涂层的微观结构开发，用作电极的有序多孔材料的结构，用于药物递送材料的复合物的纳米结构，基于嵌段共聚物的水凝胶以及水合胶原蛋白和纤维蛋白的组织等效物的结构。 cryoSEM设施所实现的研究将在各个领域产生更广泛的影响，包括涂层加工、胶体科学、多孔材料、嵌段共聚物、胶原基组织等效物、生物膜、地磁和乳液科学。 cryoSEM将提供通过其他手段无法实现的结果，不仅会影响科学理解，还会影响新材料和设备的工程设计。 结果将在出版物和演示文稿中传播，包括通过明尼苏达大学的界面和材料工程研究工业伙伴关系向工业界进行演示。新的cryoSEM系统还将通过研讨会、讲习班和演示，影响从研究生到中学生的各级学生的研究培训和教育。