Collaborative Research: Mechanical Material Removal Processes for Biological Tissue in Cardiovascular Procedures

该奖项的目标是开发生物组织加工中机械材料去除过程的实验验证物理模型。该方法是在四个相关的研究活动中表征生物组织加工的独特方面。1)描述从材料变形、翻耕到材料去除的过渡过程。具体目标是为正在研究的新型工作材料开发加工测试系统和材料去除模型。2)开发和验证加工力和碎片尺寸模型。具体目标是预测与医疗成功直接相关的加工表面和亚表面损伤。3)创建与材料去除模型直接关联的动脉变形模型。具体目的是推断动脉粥样硬化切除术（动脉粥样硬化清除血管斑块）在项目应用过程中的短期和长期效果。表征长、灵活的刀具驱动系统对刀具-工件相互作用的动态行为和影响。具体目标是为加工过程和工作损伤模型提供现实的医疗程序输入。如果成功，基础加工研究和研究成果将广泛应用于许多组织加工工艺。这项研究的好处将是提高常用医疗器械的性能，新的加工测试系统，以及新的组织加工模型，其中包括与可能的加工损伤和手术治疗成功直接相关的工作材料变形模型。该项目将扩展制造工程、生物医学工程和医疗保健的综合活动，立即将致力于积极参与研究的工程、医学和医疗器械设计方面的执业专业人员聚集在一起。这些人将带来这些领域的研究生和本科生以及工作技术人员。

The objective of this award is to develop experimentally validated physics-based models of the mechanical material removal processes in biological tissue machining. The approach is to characterize unique aspects of biological tissue machining in four related research activities. 1) Describe the transition from material deformation and plowing to material removal. The specific objective is to develop machining test systems and material removal models for the new classes of work materials being studied. 2) Develop and validate machining force and debris size models. The specific objective is to predict machined surface and subsurface damage that is directly related to medical treatment success. 3) Create artery deformation models that are directly linked to material removal models. The specific goal is to infer short- and long-term effects in the project application process of atherectomy, the removal of plaque from blood vessels. 4) Characterize the dynamic behaviour and effects of long, flexible tool drive systems on tool-work interactions. The specific objective is to provide realistic medical procedure inputs to machining process and work damage models. If successful, fundamental machining studies and research results will be widely useful in many tissue machining processes. The benefits of this research will be improved performance of commonly used medical devices, new machining test systems, and new tissue machining models that include work material deformation models directly related to possible machining damage and surgical treatment success. The project will extend the integrated activity of manufacturing engineering, biomedical engineering and health care by immediately bringing together practicing professionals in engineering, medicine and medical device design who have committed to actively participate in the research. These individuals will bring with them graduate and undergraduate students and working technicians from these fields.