Workshop: Functional Imaging for Regenerative Medicine, May 31 - June 1, 2012, Gaithersburg, MD

1242233/Vunjak-Novakovic该奖项由国家科学基金会化学、生物工程环境和运输部的生物技术、生化和生物物质工程计划以及生物光子学计划支持，将资助一个名为“再生医学(公司)的功能成像”的研讨会，该研讨会将确定机会领域，并促进组织工程和再生医学(TERM)中尖端成像方法的新合作和应用。会议成果有望帮助塑造组织工程和再生医学研究的未来。课程主题包括：(1)体外细胞功能：高分辨率单细胞成像；(2)体内细胞功能：活体细胞成像；(3)组织移植：宏观成像；(4)整体器官再生：全身成像。为了实现这一目标，研讨会将把来自术语和图像社区的领导人聚集在一起，交流想法和实用方法。研讨会旨在通过确定组织工程师从分子到宏观规模的当前需求，并考虑满足这些需求的方法，加速开发和采用先进的成像方法和工具，重点是适合体外和体内长期工作的功能性、非侵入性方法。参与者包括学术界、工业界和政府的成员，他们对术语、成像，特别是TERM中成像方法的应用感兴趣。布罗德影响-组织科学和工程使用物理、化学、生物和工程过程来控制和指导细胞的聚集行为。组织工程和再生医学疗法在产生非免疫原性器官替代或特别促进组织的愈合和再生方面具有巨大的前景。已经有证据表明，基于干细胞和生物工程的策略可以在体内用于再生心脏、神经、胰岛、膀胱和肺组织，自体皮肤替代正在开发中。此外，干细胞和生物工程技术也被用于生成体外三维模型系统，这些系统足够接近地模拟人体组织和器官，以用于毒性筛选和药物开发。虽然这些疗法和模型系统显示出非凡的前景，但它们的商业化和广泛应用在很大程度上仍然存在巨大的障碍，这在很大程度上是因为在体外和体内对这些过程进行精确的实时监测和操纵存在困难。一个特别的挑战是能够评估细胞的潜力，以及培养中细胞的哪些特征是它们在体内命运的预测因素。新的多模式成像方法对于理解体外到体内的转变将是重要的。

1242233/ Vunjak-NovakovicThis award supported by the Biotechnology, Biochemical and Biomass Engineering Program along with the Biophotonics Program in the Chemical, Bioengineering Environmental and Transport Division of NSF will fund a workshop on 'Functional imaging for regenerative medicine (FIRM)' that will identify areas of opportunity, and stimulate new collaborations and applications of cutting edge imaging methods in tissue engineering and regenerative medicine (TERM). The meeting outcomes are expected to help shape the future of tissue engineering and regenerative medicine research. Session Topics will include: (1) Cellular Function in vitro: High Resolution Single Cell Imaging, (2) Cellular Function in vivo: In Vivo Cell Imaging, (3) Tissue Grafts: Macroscopic Imaging, and (4) Regenerating Whole Organs: Whole Body Imaging.Intellectual Merit - The main objective of the workshop is to foster cutting-edge imaging for application in TERM. Toward this goal, the workshop will bring together the leaders from the TERM and imaging communities for cross-fertilization of ideas and practical approaches. The workshop aims to accelerate development and adoption of advanced imaging methodologies and tools by identifying current needs of tissue engineers, from the molecular to the macroscopic scales, and consider approaches to meet those needs, with a focus on functional, noninvasive methods appropriate for in vitro and in vivo TERM work. The participants include members of academia, industry, and government with interests in TERM, imaging, and especially the application of imaging methods in TERM.Broader Impacts - Tissue Science and Engineering uses physical, chemical, biological, and engineering processes to control and direct the aggregate behavior of cells. Tissue Engineering and Regenerative Medicine therapies have tremendous promise for generating non-immunogenic organ replacements or specifically promote healing and regeneration of tissues. Already there have been demonstrations that stem cell- and bioengineering-based strategies can be used in-vivo to regenerate heart, nerve, pancreatic islets, bladder and lung tissues, with autologous skin replacements under development. Additionally, stem cell and bioengineering technologies are also being employed toward generating in vitro three dimensional model systems that mimic human tissues and organs closely enough to be used for toxicity screening and drug development. While these therapies and model systems show exceptional promise, there remain significant barriers to their commercialization and widespread use to a large extent because of the difficulties in precise real-time monitoring and manipulation of these processes in vitro and in vivo in time and space. A particular challenge is to be able to evaluate cell potency and what characteristics of cells in culture are predictors of their fate in vivo. Novel multimodal imaging methods will be important for understanding the in vitro - in vivo transition.