权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

CAREER: Magnetic Imaging Guided Composite Materials Development

职业：磁成像引导复合材料开发

基本信息

批准号：
1253358
负责人：
Anna Cristina Samia
金额：
$ 60万
依托单位：
Case Western Reserve University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2013
资助国家：
美国
起止时间：
2013-02-01 至 2020-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1253358&HistoricalAwards=false
关键词：
CAREER Magnetic Imaging Guided Composite

项目摘要

TECHNICAL SUMMARY:This CAREER grant supported by the Solid State and Materials Chemistry (SSMC) program aims to develop a novel class of ultra-high molecular weight polyethylene (UHMWPE)-based composites with special magnetic and mechanical properties that will facilitate the in situ study of implant-type materials in various chemical and biological fluid environments using magnetic particle imaging (MPI) technologies. Linear, branched and cross-linked UHMWPE polymer structures will be filled with specifically engineered iron oxide-based nanoparticles to prepare new functional magnetic polymer composites. The magnetic and mechanical properties of the fabricated composites will be evaluated as a function of processing conditions, compositions, and resulting microstructures in order to identify good processing approaches, and promising composite formulations that have high magnetization sensitivity for imaging, combined with good mechanical properties that are comparable to the matrix polymer. The information gathered from these studies will provide valuable knowledge on wear debris formation mechanisms of biopolymers and will contribute to the fabrication of innovative composite material systems possessing highly desired magnetic properties and good mechanical performance and reliability. This work is expected to lead ultimately to the ability to track wear and the generation of debris in real time inside the body, providing a transformational tool for improving the performance of UHMWPE prostheses. Moreover, the design and monitoring of the proposed magnetic composites will directly influence the advancement of MPI technology and possibly enable the development of bench side testing tools for polymer biomaterials that will be used for in vivo biomedical applications. NON-TECHNICAL SUMMARY:Polyethylene is widely used as a component in the fabrication of joint prostheses. A major downside of this material is that it can undergo excessive wear leading to premature loosening of the implant, which in turn can lead to failure and complicated replacement revision surgeries. Studies have shown that polyethylene wear in artificial joint replacements are not always identical and are not easily explained by exclusively mechanical factors. In cases of premature and excessive wear of polyethylene bearings, chemical degradation and oxidation of the polymer can significantly lower its mechanical resistance and result in an accelerated wear-off process. While ex vivo studies have been conducted on previously used polyethylene acetabular cups to understand the factors contributing to implant failure, the degradation mechanism is still not completely understood. An improved assessment of the structural integrity of the polyethylene material used in implants as subjected to mechanical and chemical stress will provide valuable information on the material's durability, and can help predict its wear and degradation over time. To study the real-time degradation of implant materials in various chemical and biological fluid environments, the proposed project aims to develop new polyethylene composite materials that can be investigated using an emerging imaging modality called magnetic particle imaging (MPI). The proposed research will transform the wear debris monitoring of polyethylene implant materials and impact annually one million people in the U.S. alone who undergo hip and knee replacement surgeries. The educational impact of this project will build on current initiatives to educate high school, undergraduate and graduate students through the development of cross-disciplinary courses and hands-on research programs that will incorporate the interplay between materials fabrication and imaging tools. Moreover, a modular "Traveling Magnetism Show" will be developed for K-12 students at four adaptive levels and will be showcased in local schools and science museums. In addition, a new "Women in Chemistry Workshop Series at CWRU" will be established to provide a mentoring and training platform for graduate and post-graduate female chemistry students. This program will facilitate monthly discussions and workshops to tackle important aspects of career advancement specific to women scientists.

技术摘要：这项由固态和材料化学（SSMC）计划支持的CAREER资助旨在开发一类新型的超高分子量聚乙烯（UHMWPE）基复合材料，具有特殊的磁性和机械性能，这将有助于使用磁粒子成像（MPI）技术在各种化学和生物流体环境中原位研究植入型材料。线性、支化和交联UHMWPE聚合物结构将填充专门设计的氧化铁基纳米颗粒，以制备新型功能磁性聚合物复合材料。所制造的复合材料的磁性和机械性能将作为加工条件、组合物和所得微观结构的函数进行评价，以确定良好的加工方法和具有高磁化灵敏度的有前途的复合材料配方，用于成像，结合与基质聚合物相当的良好机械性能。从这些研究中收集的信息将提供有价值的知识，磨损碎片的生物聚合物的形成机制，并将有助于创新的复合材料系统具有高度期望的磁性能和良好的机械性能和可靠性的制造。这项工作有望最终实现在体内真实的跟踪磨损和碎屑生成的能力，为改善UHMWPE假体的性能提供一种转型工具。此外，所提出的磁性复合材料的设计和监测将直接影响MPI技术的进步，并可能使用于体内生物医学应用的聚合物生物材料的实验室侧测试工具的开发成为可能。非技术总结：聚乙烯广泛用作关节假体制造中的组件。这种材料的一个主要缺点是，它可能会经历过度磨损，导致植入物过早松动，这反过来又可能导致失败和复杂的置换翻修手术。研究表明，人工关节置换术中的聚乙烯磨损并不总是相同的，并且不容易完全由机械因素解释。在聚乙烯关节面过早和过度磨损的情况下，聚合物的化学降解和氧化可显著降低其机械阻力，并导致磨损过程加速。虽然已经对之前使用的聚乙烯髋臼杯进行了体外研究，以了解导致植入物失效的因素，但降解机制仍不完全清楚。对植入物中使用的聚乙烯材料在承受机械和化学应力时的结构完整性进行改进评估，将提供有关材料耐久性的有价值信息，并有助于预测其随时间的磨损和降解。为了研究植入材料在各种化学和生物流体环境中的实时降解，拟议项目旨在开发新型聚乙烯复合材料，可以使用称为磁粒子成像（MPI）的新兴成像方式进行研究。这项拟议中的研究将改变聚乙烯植入物材料的磨损碎屑监测，每年仅在美国就有100万人接受髋关节和膝关节置换手术。该项目的教育影响将建立在目前的举措，通过开发跨学科课程和实践研究计划，将材料制造和成像工具之间的相互作用，教育高中，本科和研究生。此外，还将为K-12学生开发四个适应水平的模块化“旅行磁力展”，并将在当地学校和科学博物馆展出。此外，还将设立一个新的“CWRU妇女参与化学研讨会系列”，为化学专业的研究生和研究生女学生提供指导和培训平台。该方案将促进每月的讨论和讲习班，以解决女科学家职业发展的重要方面。