CAREER: Harnessing continuous growth mechanism to synthesize water-soluble magnetic nanoparticles for magnetic particle imaging

职业：利用连续生长机制合成用于磁性粒子成像的水溶性磁性纳米粒子

• 批准号: 2144790
• 负责人: Yongfeng Zhao
• 金额: $ 50.86万
• 依托单位: Jackson State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2144790&HistoricalAwards=false
• 关键词: CAREER; Harnessing; continuous; growth; mechanism

Non-technical summary: This CAREER award supported by the Biomaterials program in the Division of Materials Research aims to understand the continuous growth mechanism of water-soluble magnetic nanoparticles (MNPs) and harness the growth mechanism to synthesize MNPs for magnetic particles imaging (MPI) application. The project serves the national interest by promoting the progress of science and advancing public health. The MPI is a promising and novel imaging modality because it can generate positive contrast signals directly from MNPs without using harmful ionizing radiation. The MPI has unlimited tissue penetration depth, low background signals, and high sensitivity. Nevertheless, the MPI is currently not available for clinical applications. One major obstacle is a lack of MPI-specific MNPs as tracers. High-performance MNPs are critical to materialize the potential of MPI in clinical translation. This project is inspired by Professor Yongfeng Zhao’s pilot study demonstrating that water-soluble MNPs can be synthesized in a continuous growth manner. The resulting MNPs show high MPI performance. However, the mechanism of the continuous growth is still unknown, and the correlation between water-soluble MNPs and MPI performance is not established. Addressing these questions will accelerate the design, synthesis, and manufacturing of high-performance MNPs for MPI. The knowledge obtained from this project will stimulate the controlled synthesis of water-soluble MNPs and clear the roadblock for the application of MPI in healthcare. This project will integrate the proposed research activities with education plans to train underrepresented students for advanced degrees. The outreach plan is to disseminate the research findings to the general public during the annual Science Maker event in the Mississippi Museum of National Science. Technical summary:The overarching goal of this proposal is to obtain a holistic molecule-level understanding of the continuous growth mechanism of water-soluble magnetic nanoparticles (MNPs) in polyols, aimed to enhance magnetic particles imaging (MPI) performance of MNPs. The research project is meaningful because MPI is an emerging tracer imaging modality that can overcome many limitations of existing imaging techniques. The properties of MNPs dictate their sensitivity and resolution, which are essential for the further application of MPI. To achieve this overarching goal, this project is designed to 1) explore the continuous growth mechanism for controlled synthesis of water-soluble MNPs; 2) unravel a living growth profile of MNPs in polyols; 3) manipulate the reaction parameters for the synthesis of water-soluble MNPs; 4) expand the mechanism to synthesize water-soluble MNPs with dopants; and 5) study the MPI properties of MNPs synthesized in polyols. This project will accelerate the selection, synthesis, and manufacturing of high-performance MNPs for MPI. The education plan is to integrate this research project with an education initiative that is designed to systematically train minority undergraduate students in the STEM area at Jackson State University (JSU) to obtain advanced degrees. The project will be integrated with a course offered at JSU through the Brookhaven National Laboratory (BNL). JSU students will interact with research scientists from BNL and learn state-of-the-art technologies on materials characterization. This research will be presented as part of the “You Be The Chemist” competition and help foster and enhance the passion for STEM among middle school students.This project is jointly funded by the Biomaterials program and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术摘要：由生物材料计划支持的材料研究部支持的职业奖项旨在了解水溶性磁性纳米粒子（MNP）的持续增长机制（MNP），并利用生长机制，以合成MNPS以实现磁性颗粒成像（MPI）的应用。该项目通过促进科学进步和推动公共卫生的进步来为国家利益提供服务。 MPI是一种有前途且新颖的成像方式，因为它可以直接从MNP中产生正造影信号，而无需使用有害的电离辐射。 MPI具有无限的组织穿透深度，低背景信号和高灵敏度。但是，MPI目前尚未用于临床应用。一个主要障碍是缺乏MPI特异性MNP作为示踪剂。高性能MNP对于在临床翻译中实现MPI的潜力至关重要。该项目的灵感来自宽冯教授的试点研究，该研究表明，水溶性MNP可以以连续的增长方式合成。由此产生的MNP显示出高的MPI性能。但是，持续生长的机制仍然未知，并且尚未确定水溶性MNP与MPI性能之间的相关性。解决这些问题将加速MPI高性能MNP的设计，合成和制造。从该项目获得的知识将刺激水溶性MNP的受控合成，并清除障碍，以在医疗保健中应用MPI。该项目将将拟议的研究活动与教育计划相结合，以培训代表性不足的学生获得高级学位。外展计划是在密西西比州国家科学博物馆举行的年度科学制造商活动中向公众传播研究结果。技术摘要：该提案的总体目标是获得对多元醇中水溶 - 氧磁纳米颗粒（MNP）连续生长机理的整体分子级的理解，旨在增强MNP的磁性颗粒（MPI）性能。该研究项目是有意义的，因为MPI是一种新兴的示踪影像模式，可以克服现有成像技术的许多局限性。 MNP的特性决定了它们的敏感性和解决方案，为了实现这一总体目标，该项目旨在1）探索控制水溶性MNP的持续生长机制； 2）揭开多元醇中MNP的生活生长特征； 3）操纵反应参数以合成水溶性MNP； 4）扩展机制以与掺杂剂合成水溶性MNP； 5）研究多元醇合成的MNP的MPI特性。该项目将加速MPI高性能MNP的选择，合成和制造。教育计划是将该研究项目与一项教育计划融合在一起，该计划旨在系统地培训杰克逊州立大学（JSU）STEM地区的少数族裔本科生，以获得高级学位。该项目将与Brookhaven国家实验室（BNL）在JSU提供的课程集成。 JSU学生将与BNL的研究科学家进行互动，并学习有关材料表征的最先进技术。 This research will be presented as part of the “You Be The Chemist” competition and help foster and enhance the passion for STEM among middle school students.This project is jointly funded by the Biomaterials program and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed honestly of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

项目成果

The influence of the polyol solvents on the continuous growth of water-dispersible iron oxide nanoparticles

• DOI: 10.1557/s43578-023-01236-x
• 发表时间: 2023-12
• 期刊: Journal of Materials Research
• 影响因子: 2.7
• 作者: Jing Qu;Pohlee Cheah;Daniel Adams;Charles Collen;Yongfeng Zhao

In situ formation of low-valence state cobalt cation in octahedral sites of Co9S8 for highly efficient electrocatalytic hydrogen evolution

• DOI: 10.1016/j.mtener.2024.101494
• 发表时间: 2024-01-19
• 期刊: MATERIALS TODAY ENERGY
• 影响因子: 9.3
• 作者: Tian，Bin;Cheah，Pohlee;Zhao，Yongfeng
• 通讯作者: Zhao，Yongfeng