CAREER: Vasopressin-mediated regulation of juvenile social behaviors

职业：加压素介导的青少年社会行为调节

• 批准号: 1253386
• 负责人: Alexa Veenema
• 金额: $ 87.45万
• 依托单位: Boston College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2017-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1253386&HistoricalAwards=false
• 关键词: CAREER; Vasopressin; mediated; regulation; juvenile

The neuropeptide arginine-vasopressin (AVP) is involved in the regulation of diverse social behaviors in adulthood. However, it is less clear how the AVP system in the brain regulates social behaviors during the juvenile period. This project will elucidate the mechanisms by which AVP regulates social play and social novelty-preference in juvenile male and female rats. Complementary approaches will be used, including microdialysis, pharmacological manipulations, and neuronal activation, to elucidate interactions between AVP and GABA systems in the lateral septum and AVP-mediated alterations in neuronal activation in projection areas of the lateral septum. The results will provide new insights on the regulation of social interactions among juveniles, which are known to be critically important for development of social competence and socialization in mammals, including rodents and humans. The research will be integrated with an education plan in which new initiatives will be developed to expose high school and undergraduate students, particularly those from minority and under-represented groups, to hands-on behavioral neuroscience research. The research and education plans will build a firm foundation for a lifetime of integrated contributions to behavioral neuroscience research and education. Research findings will be disseminated to the public through public lectures, publications, and a web site. The archiving, access, and sharing of data will be according to Boston College policies.

神经肽精氨酸加压素（AVP）参与成年期各种社会行为的调节。然而，脑中AVP系统如何调节青少年时期的社会行为尚不清楚。该项目将阐明AVP调节幼年雄性和雌性大鼠的社交游戏和社交新奇偏好的机制。互补的方法将被使用，包括微透析，药理学操作，和神经元激活，阐明AVP和GABA系统之间的相互作用，在侧隔和AVP介导的改变，在侧隔的投射区的神经元激活。研究结果将为青少年之间的社会互动调节提供新的见解，这对哺乳动物（包括啮齿动物和人类）的社会能力和社会化的发展至关重要。这项研究将与一项教育计划相结合，该计划将制定新的举措，让高中和本科生，特别是来自少数民族和代表性不足的群体的学生，接触动手的行为神经科学研究。研究和教育计划将为终身对行为神经科学研究和教育的综合贡献奠定坚实的基础。研究结果将通过公开讲座、出版物和网站向公众传播。数据的存档，访问和共享将根据波士顿学院的政策。