Centrally mediated cardiovacular depressant actions of arginine vasopressin in Brattleboro rat and spontaneously hypertensive rat.

在卒中易发自发性高血压大鼠和Wistar-Kyoto大鼠中研究了精氨酸加压素对心血管的影响。将精氨酸加压素以2 pg/kg/min （4.6 <micrn>/hr）的速率注入清醒大鼠脑室内21小时，监测血压和心率。农业加压素在Wistar-Kyoto大鼠中引起短暂性高血压和心动过速，而在卒中易发的自发性高血压大鼠中引起延迟性低血压和心动过缓。对后者的影响持续24 ~ 72小时后停止输注。以2 pg/kg/min的速率静脉给药精氨酸加压素未引起这些大鼠血压和心率的任何变化。这些结果表明精氨酸抗利尿素的中枢作用是抑制心血管活动，至少在卒中易发的自发性高血压大鼠中是如此。

The cardiovascular effects of centrally administered arginine vasopressin were studied in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. Arginine vasopressin was infused intracerebroventricularly into conscious rats at a rate of 2 pg/kg/min (4.6 <micrn>/hr) for 21 hours, and blood pressure and heart rate were monitored. Agrinine vasopressin caused transient hypertension and tachycardia in Wistar-Kyoto rats, whereas it induced delayed hypotension and bradycardia in stroke-prone spontaneously hypertensive rats. The effects on the latter lasted for 24 to 72 hours after cessation of the infusion. Intravenous administration of arginine vasopressin at a rate of 2 pg/kg/min did not cause any change in blood pressure and heart rate in these rats. These results suggest that arginine vasopressin acts centrally to depress cardiovacular activites, at least in stroke-prone spontaneously hypertensive rats.