Centrally mediated cardiovacular depressant actions of arginine vasopressin in Brattleboro rat and spontaneously hypertensive rat.

精氨酸加压素对布拉特尔伯勒大鼠和自发性高血压大鼠的中枢介导的心血管抑制作用。

• 批准号: 61570401
• 负责人: IMAI Yutaka
• 金额: $ 1.09万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570401/
• 关键词: Vasopiressin; Long-Evans rat; Brattleboro rat; Spontaneous hypertensive rat; Cerebrolateral ventricle; Depressor effect; 徐脈作用; 中枢神経; 孤束核; 心血管反応; 脳定位固定; 降圧反応; 昇圧反応

The cardiovascular effects of centrally administered arginine vasopressin were studied in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. Arginine vasopressin was infused intracerebroventricularly into conscious rats at a rate of 2 pg/kg/min (4.6 <micrn>/hr) for 21 hours, and blood pressure and heart rate were monitored. Agrinine vasopressin caused transient hypertension and tachycardia in Wistar-Kyoto rats, whereas it induced delayed hypotension and bradycardia in stroke-prone spontaneously hypertensive rats. The effects on the latter lasted for 24 to 72 hours after cessation of the infusion. Intravenous administration of arginine vasopressin at a rate of 2 pg/kg/min did not cause any change in blood pressure and heart rate in these rats. These results suggest that arginine vasopressin acts centrally to depress cardiovacular activites, at least in stroke-prone spontaneously hypertensive rats.

在易卒中的自发性高血压大鼠和Wistar-Kyoto大鼠中研究了集中施用精氨酸加压素的心血管效应。将精氨酸加压素以2 pg/kg/min（4.6 /hr）的速率脑室内注入清醒大鼠<micrn>21小时，并监测血压和心率。精氨酸加压素引起短暂的高血压和心动过速的Wistar-Kyoto大鼠，而它诱导迟发性低血压和心动过缓的中风倾向的自发性高血压大鼠。对后者的影响持续24至72小时后停止输注。以2 pg/kg/min的速率静脉给予精氨酸加压素不会引起这些大鼠的血压和心率发生任何变化。这些结果表明，精氨酸加压素作用于中枢抑制心血管活动，至少在易卒中的自发性高血压大鼠。

项目成果

Imai Yutaka: J Hypertension. 4(supple). s662-s664 (1986)

今井丰：J 高血压。

Imai Yutaka: Clin Exp Hypertension. A9. 67-74 (1987)

Imai Yutaka：临床实验高血压。

Imai Yutaka: Hypertension. 10. 346-349 (1987)

今井丰：高血压。

Imai et al: Tohoku J exp Med. 151. 1-16 (1987)

Imai 等人：Tohoku J exp Med。

Imai et al: American Journal of Physiology.

Imai 等人：美国生理学杂志。