Centrally mediated cardiovacular depressant actions of arginine vasopressin in Brattleboro rat and spontaneously hypertensive rat.

研究了中枢应用精氨酸加压素对卒中易患自发性高血压大鼠和Wistar-京都大鼠的心血管效应。将精氨酸加压素以2pg/kg/min(4.6微克/分/小时)的速度注入清醒大鼠的脑室，持续21h，监测血压和心率。在Wistar-京都大鼠中，加压素可引起一过性高血压和心动过速，而在易卒中的自发性高血压大鼠中，则可引起迟发性低血压和心动过缓。对后者的影响在停药后持续24~72小时。静脉注射2pg/kg/min的精氨酸加压素对大鼠的血压和心率无明显影响。这些结果表明，精氨酸加压素发挥中枢作用，抑制心血管活动，至少在易中风的自发性高血压大鼠中是这样。

The cardiovascular effects of centrally administered arginine vasopressin were studied in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. Arginine vasopressin was infused intracerebroventricularly into conscious rats at a rate of 2 pg/kg/min (4.6 <micrn>/hr) for 21 hours, and blood pressure and heart rate were monitored. Agrinine vasopressin caused transient hypertension and tachycardia in Wistar-Kyoto rats, whereas it induced delayed hypotension and bradycardia in stroke-prone spontaneously hypertensive rats. The effects on the latter lasted for 24 to 72 hours after cessation of the infusion. Intravenous administration of arginine vasopressin at a rate of 2 pg/kg/min did not cause any change in blood pressure and heart rate in these rats. These results suggest that arginine vasopressin acts centrally to depress cardiovacular activites, at least in stroke-prone spontaneously hypertensive rats.