CAREER: Biophysical Mechanisms of Pulmonary Surfactant and its Interactions with Therapeutic Agents

职业：肺表面活性剂的生物物理机制及其与治疗药物的相互作用

• 批准号: 1254795
• 负责人: Yi Zuo
• 金额: $ 40万
• 依托单位: University of Hawaii
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1254795&HistoricalAwards=false
• 关键词: CAREER; Biophysical; Mechanisms; Pulmonary; Surfactant

AbstractPI Yi Zuo1254795Pulmonary surfactant (PS) plays a crucial role in maintaining the normal respiratory mechanics by reducing the alveolar surface tension to near-zero. The research goal of this proposal is to study the biophysical mechanisms of PS and PS-drug interactions, using combined experimental and computational methods. There are 2 objectives: Objective 1. Study of biophysical mechanisms of natural pulmonary surfactant. Objective 2. Study of interactions between natural pulmonary surfactant and therapeutic agents (corticosteroids).The proposed studies include combinations of state-of-the-art methods that are being used in novel ways to gain a complete understanding of the mechanisms involved. This work is important to the general public because it will provide new insight into the role that PS plays in health and disease, thus advancing neonatal care in the United States. The primary educational goal of this proposal is to improve participation and success of Native Hawaiians, Pacific Islanders, and students from other underrepresented groups. The PI will also collaborate with the March of Dimes Foundation Hawaii Chapter to disseminate basic knowledge of prevention and management of preterm birth to Hawaiian youth.

肺表面活性物质（pulmonary surfactant，PS）通过降低肺泡表面张力至接近于零，在维持正常呼吸力学中起着至关重要的作用。本项目的研究目标是采用实验和计算相结合的方法，研究PS和PS-药物相互作用的生物物理机制。有两个目标：目标1。天然肺表面活性物质生物物理机制的研究。目标2.天然肺表面活性物质和治疗药物（皮质类固醇）之间相互作用的研究。拟议的研究包括以新方式使用的最先进方法的组合，以全面了解所涉及的机制。这项工作对公众很重要，因为它将为PS在健康和疾病中的作用提供新的见解，从而推动美国的新生儿护理。该提案的主要教育目标是提高夏威夷土著人、太平洋岛民和其他代表性不足群体的学生的参与和成功。PI还将与March of Dimes基金会夏威夷分会合作，向夏威夷青年传播预防和管理早产的基本知识。