CAREER: Mechanistic Investigations of the Excited-State Dynamics in Thiobase and Pterin UVA Sensitizers and in Their DNA Constructs

点击翻译按钮获取中文摘要

Through this CAREER award, supported by the Chemical Structure, Dynamics and Mechanisms-B Program of the Division of Chemistry, Prof. Carlos E. Crespo-Hernández of Case Western Reserve University will develop an integrated research and education program based upon investigations of the excited-state dynamics in UVA-sensitizers and of the photosensitized reactions that underlay DNA damage. This information along with the techniques used to obtain it are central to understanding a host of biological processes, including cell death and skin cancer, and for developing therapeutics for a range of disorders. The research, by providing an understanding of these reactions, will scrutinize fundamental ideas in the fields of organic photochemistry and photobiology. The educational objectives seek to motivate students at various educational levels to enter and persist in science and technology studies and careers by: developing modules that teach fundamental concepts in photochemistry and time-resolved spectroscopy and that incorporate active learning strategies; providing research opportunities for high school and undergraduate students; and mentoring and serving as a role model for underrepresented and disadvantaged students. Photochemistry involves the study of the interaction of light with matter. Such interactions are paramount in vision, photosynthesis, solar energy conversion and storage, and photonic/optoelectronic devices. In addition, photochemistry of biologically related molecules is paramount for the prevention and treatment of skin cancer. In skin cancer, light causes damage to DNA by various mechanisms that are not fully understood. DNA damage in skin exposed to ultraviolet light emanating from the sun primarily depends on non-DNA biomolecules acting as energy transfer units. It is a goal of the Crespo-Hernández group to investigate the reactions in DNA that are initiated by these biomolecules when acting as energy/charge transfer units. The educational aspects of the CAREER plan involves the design of concept-centered modules and laboratory sessions for undergraduate and graduate courses that systematically incorporate active learning and teaching strategies to enhance student learning and retention. These activities will also contribute to a broader understanding of the variables that affect the performance and continuing interest of students in science and technology fields. Exposure of pre-college and postsecondary students, including underrepresented and disadvantaged students, to multidisciplinary research, modern photochemistry, spectroscopy, and computational methods will motivate their participation in science, spark their interest in important areas of science and technology, and contribute to the nation's scientific workforce and economic competitiveness.