Single Neuron Resolution of Flow Sensing in the Zebrafish Lateral line during development

斑马鱼侧线发育过程中流量传感的单神经元分辨率

• 批准号: 1257150
• 负责人: James Liao
• 金额: $ 51.61万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1257150&HistoricalAwards=false
• 关键词: Single; Neuron; Resolution; Flow; Sensing

The neural processing of auditory vibrations plays a crucial role in hearing and communication. This process starts when hair cells transform a mechanical stimulus into a neural signal, and continues as the signal is transmitted into the brain for processing. This project uses physiological techniques to understand the functional relationships between neurons associated with hair cells. The goal is to provide an understanding of these neurons in a simple system in order to better understand their role in more complex vertebrate hair cell systems. The broader impact of this work is to advance the understanding of how normal hair cell systems function is essential for continued progress towards of better understanding of auditory neural processing during health and disease. It is anticipated that there will be many applications of this work, from diagnosing hearing disorders to inspiring robotic sensor design. The broader impact of this work will also include training of undergraduates, graduate students and post doctoral associates in Northeast Florida, a region which historically has been plagued with inadequate scientific literacy, and prepare these individuals for independent scientific careers.

听觉振动的神经加工在听觉和交流中起着至关重要的作用。这一过程始于毛细胞将机械刺激转化为神经信号，并随着信号被传输到大脑进行处理而继续。这个项目使用生理学技术来了解与毛细胞相关的神经元之间的功能关系。其目的是在一个简单的系统中提供对这些神经元的了解，以便更好地了解它们在更复杂的脊椎动物毛细胞系统中的作用。这项工作的更广泛的影响是促进对正常毛细胞系统如何功能的理解，这对于继续在健康和疾病期间更好地理解听觉神经处理是必不可少的。预计这项工作将有许多应用，从诊断听力障碍到启发机器人传感器设计。这项工作的更广泛影响还将包括在佛罗里达州东北部培训本科生、研究生和博士后助理，并为这些人的独立科学生涯做好准备。佛罗里达州东北部历史上一直存在科学素养不足的问题。

项目成果

Corollary discharge prevents signal distortion and enhances sensing during locomotion

伴随放电可防止信号失真并增强运动过程中的感测

• DOI: 10.1101/2021.02.15.431323
• 发表时间: 2021
• 期刊: bioRxiv
• 作者: Skandalis, *;Lunsford, Elias T.;Liao*, James C.
• 通讯作者: Liao*, James C.