Rational Design of Eco-Friendly Homogeneous Catalysis by Rhodium- and Ruthenium-Catalyzed C-H Bond Activation and Decarboxylation

铑和钌催化 C-H 键活化和脱羧的环保均相催化的合理设计

• 批准号: 1301409
• 负责人: Pinjing Zhao
• 金额: $ 41万
• 依托单位: North Dakota State University Fargo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1301409&HistoricalAwards=false
• 关键词: Rational; Design; Eco; Friendly; Homogeneous

The Division of Chemistry supports the efforts of Professor Pinjing Zhao of North Dakota State University Fargo for catalyst development and increased mechanistic understanding of rhodium-and ruthenium-mediated carbon-hydrogen (C-H) bond activation and decarboxylation. This research project develops the [3+2] reaction of unsubstituted imines, further develops catalytic C-H alkylation of electron deficient arenes, and investigates rhodium-mediated stoichiometric and catalytic decarboxylation. A number of rhodium(I) and ruthenium(II) complexes with phosphine and N-heterocyclic carbene (NHC) ligands are isolated and characterized. The research plan is integrated with educational and outreach activities through the COINS (Career Opportunities In Natural Sciences) Program. This program encourages undergraduate and graduate students to explore various career opportunities in the natural sciences and reaches out to rural communities in the region to enhance public awareness of scientific research and career opportunities. The NSF Division of Chemistry supports the efforts of Professor Pinjing Zhao of North Dakota State University Fargo for the development of transition metal-based homogeneous catalysts. Rational design of efficient catalytic processes relies heavily on mechanistic understanding of relevant elementary organometallic reactions. Towards this goal, Professor Zhao and his group develop metal-catalyzed coupling reactions for the efficient carbon-carbon and carbon-nitrogen bond formations needed for the synthesis of new pharmaceuticals and commodity chemicals. In addition to his research, Professor Zhao initiated and leads the educational and outreach program, Career Opportunities in Natural Sciences (COINS). Through this award and the COINS Program, Professor Zhao organizes annual summer workshops for 15-20 high school students and their science teachers in rural North Dakota and western Minnesota. Students and faculty participate in discussions on the social and economic impacts of research advances, technology transfer and commercialization, and career opportunities in chemistry and other natural sciences.

化学系支持北达科他州立大学法戈分校赵品静教授在催化剂开发和增加对Rh和Ru介导的碳氢(C-H)键活化和脱羧化机理的了解方面所做的努力。本研究项目发展了未取代亚胺的[3+2]反应，进一步发展了电子缺乏芳烃的催化C-H烷基化反应，并研究了Rh催化的化学计量和催化脱羧基反应。分离和表征了一系列含膦和N-杂环卡宾(NHC)配体的Rh(I)和Ru(II)配合物。研究计划通过COINS(自然科学中的职业机会)计划与教育和外展活动相结合。该计划鼓励本科生和研究生探索自然科学领域的各种职业机会，并接触到该地区的农村社区，以提高公众对科学研究和职业机会的认识。美国国家科学基金会化学部支持北达科他州立大学法戈分校赵品静教授开发基于过渡金属的均相催化剂。高效催化过程的合理设计在很大程度上依赖于对相关基本有机金属反应的机理理解。为了实现这一目标，赵教授和他的团队开发了金属催化的偶联反应，以形成合成新药物和商品化学品所需的高效碳-碳键和碳-氮键。除了他的研究外，赵教授还发起并领导了教育和推广计划-自然科学职业机会(COINS)。通过这个奖项和硬币计划，赵教授每年为北达科他州和明尼苏达州西部农村地区的15-20名高中生和他们的科学老师组织暑期工作坊。学生和教职员工参与讨论研究进步、技术转让和商业化对社会和经济的影响，以及化学和其他自然科学领域的职业机会。