Gated Molecular Encapsulation in Water

水中的门控分子封装

• 批准号: 1305179
• 负责人: Jovica Badjic
• 金额: $ 41万
• 依托单位: Ohio State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1305179&HistoricalAwards=false
• 关键词: Gated; Molecular; Encapsulation; Water

The Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division supports studies of professor Jovica D. Badjic of the Ohio State University on elucidating mechanisms and operation of gated molecular baskets in organic and aqueous media. The first objective of the program is to disclose rules that characterize the kinetics of stereoselective gated encapsulation and investigate the importance of the process of gating for (a) completing a kinetic resolution of stereoisomers and (b) controlling the outcome of chemical reactions. The second objective of the program centers on exploring the kinetics of gated encapsulation in aqueous media. In particular, the aim is to develop water-soluble baskets and study/optimize their mechanism of action. The hydrophobic effect, in synergy with directional non-covalent interactions, is expected to permit the gating for modulating the encapsulation kinetics and delivery of useful drugs in water. Finally, the benefit of molecular encapsulation and gating for promoting organocatalytic transformations in water is to be investigated for developing aqueous supramolecular catalysts.A fundamental understanding of the translocation of molecules and its control in complex chemical systems will help developing more effective catalysts for the conversion of feedstock chemicals into valuable products in future. In addition, exploring new ways for a delivery of potent drugs at a precise rate will benefit society by transforming current pharmaceutical technologies. The proposed program is designed to educate graduate and postdoctoral students to identify research opportunities beyond the field of supramolecular chemistry. In addition, the proposed work aims to enhance cultural and gender diversity at all levels and increase the number of underrepresented minorities and women researchers at the Ohio State University.

化学系的大分子，超分子和纳米化学项目支持Jovica D教授的研究。俄亥俄州州立大学的Badjic在有机和水介质中阐明了门控分子篮的机制和操作。该计划的第一个目标是公开的规则，表征的立体选择性门控封装的动力学和调查的门控过程的重要性（a）完成立体异构体的动力学决议和（B）控制化学反应的结果。该计划的第二个目标是探索水介质中门控包封的动力学。特别是，目标是开发水溶性篮子并研究/优化其作用机制。与定向非共价相互作用协同的疏水效应预期允许用于调节包封动力学和在水中递送有用药物的门控。最后，对水相超分子催化剂的发展进行了展望，对水相超分子催化剂中分子的迁移及其控制的研究有助于开发更有效的水相超分子催化剂，将原料化学品转化为有价值的产品。此外，探索以精确速度输送强效药物的新方法将通过改变当前的制药技术而造福社会。该计划旨在教育研究生和博士后学生，以确定超分子化学领域以外的研究机会。此外，拟议的工作旨在加强各级的文化和性别多样性，增加俄亥俄州州立大学代表性不足的少数民族和妇女研究人员的人数。