Statistical Physics of Brain Networks

在这个项目中，PI将开发一个理论框架来理解大脑网络中的信息处理。理论发展将通过在体内动物实验中观察微电刺激动物的血液动力学和电神经活动来验证在Canals合作实验室(Alicante)进行的实验。大量的理论分析和实验数据将被用来分析大脑作为一个网络网络。这将涉及一个新的理论框架，旨在强有力地确定模块如何在不同的规模上动态形成和共享信息。网络分析将从超级传播者和超级抑制者节点、级联效应、健壮性和对节点故障的脆弱性方面揭示对控制大脑功能至关重要的大脑节点。PI的数学框架挑战了当前的思维，即大脑的功能结构是一个小世界和无标度的网络，其定义是短路径、大的局部聚集性和单度分布。小世界网络被提出来解决一个基本难题：大脑需要形成模块，这些模块应该足够独立，以保证功能专门化，并充分连接，以绑定多个处理器，以实现高效的信息传输。然而，这种结构在生成小世界的捷径和模块化的持久性之间存在内在的紧张；模块化是一种与局部集群无关的全局属性。在这个项目中，PI偏离了目前对大脑功能结构的思考，用分层网络的概念取代了小世界的概念，该网络将大脑描述为一组由弱/强链接组成的分层模块。提出的理论对大脑的大规模组织具有更广泛的意义，将网络的数学理论扩展到全新的信息处理系统。这项研究的发现将不仅对系统神经科学产生影响，还将对从技术、社会到生物网络的许多复杂系统产生影响。这一提议代表了两位在统计物理和复杂网络方面拥有专业知识的物理学家和一位神经科学家的实验室之间的共生。这样的环境将为参与该项目的学生提供跨学科和国际机会。更广泛的教育影响包括来自CCNY的代表不足的少数民族学生的参与和课程开发。

In this project the PIs will develop a theoretical framework to understand information processing in brain networks. The theoretical developments will be tested with experiments done in the collaborating lab of Canals (Alicante) by observation of the hemodynamic and electrical neural activity in animal with micro-electric stimulation in in-vivo animal experiments. A vast corpus of theoretical analysis and experimental data will serve to analyze the brain as a network of networks. This will involve a novel theoretical framework conceived to robustly determine how modules dynamically form and share information at different scales. The network analysis will reveal the brain nodes that are essential to control brain functionality in terms of super-spreaders and super-inhibitor nodes, cascading effects, robustness and vulnerability to node failure. The mathematical framework of the PIs challenges current thinking regarding the functional structure of the brain as a small-world and scale-free network, which is defined by short paths, large local clustering and a single degree distribution. Small-world networks have been proposed to solve a basic conundrum: the brain needs to form modules which ought to be sufficiently independent to guarantee functional specialization and sufficiently connected to bind multiple processors for efficient information transfer. However, this structure presents an intrinsic tension between shortcuts generating small-worlds and the persistence of modularity; a global property unrelated to local clustering. In this project the PIs depart from the current thinking in brain functional structure, replacing the concept of small-world by that of hierarchical Networks of Networks that describes the brain as a set of hierarchical modules made of weak/strong links. The broader significance of the proposed theory for the large-scale organization of the brain extends the mathematical theory of networks to radically novel information processing systems. The findings from this research will have implications, not only for systems neuroscience, but also for a number of complex systems ranging from technological, social to biological networks. This proposal represents a symbiosis between the labs of two physicists with expertise in statistical physics and complex networks and a neuroscientist. Such a setting will provide interdisciplinary and international opportunities to students involved in this project. Further broader educational impacts include involvement of underrepresented minority students from CCNY and curriculum development.