Chemical orthogonality in tandem differential mobility spectrometry at ambient pressure

环境压力下串联差分迁移谱的化学正交性

• 批准号: 1306388
• 负责人: Gary Eiceman
• 金额: $ 40万
• 依托单位: New Mexico State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1306388&HistoricalAwards=false
• 关键词: Chemical; orthogonality; tandem; differential; mobility

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry and the Office of Experimental Program to Stimulate Competitive Research (EPSCoR), Professor Gary Eiceman at New Mexico State University and his group will explore and develop enhanced capabilities in chemical measurements using ion mobility spectrometry (IMS). Increases in specificity of a chemical identification of substances through IMS will be introduced using orthogonality provided by ion transformations in a tandem differential IMS analyzer. Ions which are mobility selected in a first mobility analyzer and passed into a reactive zone, are subsequently reacted or fragmented using molecule selective pathways before entering a second mobility analyzer. Orthogonality can be added through changes in strong electric fields and studies will disclose quantitatively the effect of field strength and ion structure on dissociation or fragmentation reactions. Investigations will focus, for selected pharmaceutical substances and pesticides, on the stability and mobility of clusters formed between sample-derived ions and specific reagent gases. The influence on ion chemistry and chemical orthogonality of temperature, moisture, and vapor concentrations in air at ambient pressure will be explored and assessed for specificity of chemical measurements toward a next generation of IMS instruments. Ion mobility spectrometry is central to military preparedness and commercial aviation security with emerging impact in clinical diagnostics and industrial process control. Impacts of these studies should include the education of a new generation of students in gas phase ion-molecule chemistry at ambient pressure and should provide new capabilities for specific measurement challenges within industry and government.

在化学系化学测量和成像项目和刺激竞争研究实验项目办公室（EPSCoR）的支持下，新墨西哥州立大学的Gary Eiceman教授和他的团队将探索和开发使用离子迁移谱法（IMS）的化学测量增强能力。利用串联差分IMS分析仪中的离子转化提供的正交性，通过IMS对物质进行化学鉴定的特异性将得到提高。在第一迁移率分析仪中选择迁移率并进入反应区的离子随后在进入第二迁移率分析仪之前使用分子选择途径反应或破碎。通过强电场的变化可以增加正交性，研究将定量地揭示场强和离子结构对解离或破碎反应的影响。对于选定的药物物质和农药，调查将集中在样品衍生离子和特定试剂气体之间形成的团簇的稳定性和流动性上。在环境压力下，将探索和评估空气中温度、湿度和蒸汽浓度对离子化学和化学正交性的影响，以确定下一代IMS仪器的化学测量特异性。离子迁移率光谱法是军事准备和商业航空安全的核心，在临床诊断和工业过程控制方面具有新兴的影响。这些研究的影响应该包括教育新一代学生在环境压力下的气相离子分子化学，并为工业和政府的特定测量挑战提供新的能力。