Structural transitions, energetics, and folding pathways of colloidal clusters
胶体簇的结构转变、能量学和折叠途径
基本信息
- 批准号:1306410
- 负责人:
- 金额:$ 37.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-06-01 至 2018-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
****Technical Abstract****The structures and transitions of colloidal clusters may reveal local mechanisms governing bulk phenomena such as nucleation and structural arrest. Such clusters are also useful model systems for understanding self-assembly pathways. This experimental program will investigate three-dimensional colloidal clusters composed of 6-30 particles held together by weak interactions such as depletion or DNA-mediated binding. An advanced imaging method, digital holographic microscopy, will be used to measure the positions and motions of every particle in a cluster with sub-millisecond temporal resolution and 10 nm precision in all three dimensions. This technique enables detailed, quantitative studies of the ground states, equilibrium structural transitions, and topological transitions of the clusters. Results will be compared and used as input to energy landscape calculations, with the broad goal of understanding how phase transitions and nonequilibrium phenomena emerge as the size of the system increases. The program will train a graduate student and undergraduate in soft matter physics and applied optics. An outreach and education program will bring 20-40 high-school physics students from Cambridge and Boston-area public schools to Harvard for a series of discovery-based labs on waves, optics, and holography.****Non-Technical Abstract****This award supports experimental research on unusual materials called clusters, sometimes called an "intermediate state of matter." Compared to the usual states of matter we encounter in our daily lives -- gases, liquids, and solids -- clusters consist of a far smaller number of atoms or particles. Because they are less complex than ordinary matter, they are in principle easier to understand. Studying how these clusters change their shapes over time and in the presence of external forces could help solve longstanding challenges in materials science, such as how crystals form and why they sometimes form disordered structures called glasses, both of which are important classes of materials for industry. However, clusters remain difficult to prepare and study experimentally. This project will take advantage of a new way to make clusters using microscopic particles called colloids, which can be seen with an optical microscope. The motion of particles in the clusters will be observed using an advanced imaging method involving holograms. The project will train a Ph.D. student and undergraduate in physics, materials science, and holography, an emerging high-technology field. The project will also educate 20-40 public high school students in physics and optics through a series of labs designed to be fun, engaging, and aimed toward motivating them to continue studying science.
* 技术摘要 * 胶体团簇的结构和转变可能揭示局部机制管理散装现象,如成核和结构逮捕。这种簇也是理解自组装途径的有用模型系统。这个实验项目将研究由6-30个颗粒组成的三维胶体簇,这些颗粒通过弱相互作用(如耗尽或DNA介导的结合)聚集在一起。一种先进的成像方法,数字全息显微镜,将用于测量一个集群中每个粒子的位置和运动,在所有三个维度上具有亚毫秒的时间分辨率和10纳米的精度。这种技术使详细的,定量研究的基态,平衡结构转变,和拓扑结构的集群转换。结果将进行比较,并作为输入能源景观计算,了解如何相变和非平衡现象出现的系统的大小增加的广泛目标。该计划将培养软物质物理学和应用光学的研究生和本科生。一个推广和教育计划将把20-40名来自剑桥和波士顿地区公立学校的高中物理学生带到哈佛,参加一系列关于波、光学和全息术的发现实验室。非技术摘要 * 该奖项支持对称为团簇的不寻常材料(有时称为“中间物质状态”)的实验研究。“与我们日常生活中遇到的常见物质状态-气体,液体和固体-相比,集群由数量少得多的原子或粒子组成。因为它们没有普通物质那么复杂,所以原则上更容易理解。研究这些团簇如何随着时间的推移以及在外力的存在下改变它们的形状,可以帮助解决材料科学中长期存在的挑战,例如晶体如何形成以及为什么它们有时会形成称为玻璃的无序结构,这两者都是重要的工业材料类别。 然而,团簇仍然难以制备和实验研究。 该项目将利用一种新的方法,使用称为胶体的微观颗粒来制造团簇,这种颗粒可以用光学显微镜观察到。 将使用涉及全息图的先进成像方法观察团簇中粒子的运动。该项目将培养一名博士。学生和本科生在物理学,材料科学和全息术,一个新兴的高科技领域。该项目还将通过一系列有趣、吸引人的实验室,对20-40名公立高中学生进行物理和光学方面的教育,旨在激励他们继续学习科学。
项目成果
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Vinothan Manoharan其他文献
Vinothan Manoharan的其他文献
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{{ truncateString('Vinothan Manoharan', 18)}}的其他基金
CAREER: High-speed 3D Imaging of Colloidal Self-Assembly with Digital Holographic Microscopy
职业:利用数字全息显微镜对胶体自组装进行高速 3D 成像
- 批准号:
0747625 - 财政年份:2008
- 资助金额:
$ 37.8万 - 项目类别:
Standard Grant
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