RUI: CMI: Effect of solution conditions and analyte properties on negative ion electrospray ionization

RUI：CMI：溶液条件和分析物性质对负离子电喷雾电离的影响

• 批准号: 1307226
• 负责人: Christine Hughey
• 金额: $ 23.85万
• 依托单位: James Madison University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307226&HistoricalAwards=false
• 关键词: RUI; CMI; Effect; solution; conditions

With support from the Chemical Measurement and Imaging Program in the Division of Chemistry, Professors Christine Hughey and Stephen Lucas and their groups will explore the fundamentals of negative ion electrospray ionization, an ionization technique that selectively charges acidic molecules by deprotonation prior to mass spectrometric detection. Specifically, the researchers will investigate the mechanisms of ionization under different pH regimes and develop a multivariate model that will predict response for physiochemically diverse acidic analytes under different solution/pH conditions. In pursuit of these objectives, the team will test the hypothesis that analyte physiochemical properties have a greater impact on ionization efficiency than the route of ion formation. Since James Madison University is a predominately undergraduate institution (PUI), undergraduate chemistry and mathematics majors will conduct the research proposed and, in doing so, will learn how to effectively collaborate and communicate across disciplines. In addition, Professors Hughey and Lucas have a demonstrated track record with the involvement of women and the deaf in their research. The groups will continue to be an integral part of the research project.

从化学测量和成像计划在化学部的支持下，教授克莉丝汀和斯蒂芬卢卡斯和他们的小组将探讨负离子电喷雾电离，电离技术，选择性电荷酸性分子通过去质子化之前质谱检测的基本原理。具体而言，研究人员将研究不同pH值条件下的电离机制，并开发一种多变量模型，预测不同溶液/pH值条件下物理化学多样性酸性分析物的响应。为了实现这些目标，研究小组将检验以下假设：分析物的理化性质对电离效率的影响大于离子形成途径。由于詹姆斯麦迪逊大学是一个占主导地位的本科院校（PUI），本科化学和数学专业将进行拟议的研究，并在这样做，将学习如何有效地跨学科合作和沟通。此外，休伊和卢卡斯教授在妇女和聋人参与其研究方面有着良好的记录。这些小组将继续是研究项目的一个组成部分。