Soft Materials: Synthesis and Properties

软材料：合成与性能

• 批准号: 1310266
• 负责人: David Weitz
• 金额: $ 56万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1310266&HistoricalAwards=false
• 关键词: Soft; Materials; Synthesis; Properties

****Technical Abstract****The proposed research focuses on the three main themes in soft matter physics: Properties of colloidal gels formed with depletion attraction will be investigated. The information will help explain the origin of delayed collapse, a major impediment to the use of such gels to stabilize commercial products. In a biophysics effort, the control of cell stiffness by cell volume will be explored. If preliminary results prove to be true, this would be a transformational change in our understanding of cell properties. Finally, new microfluidic devices will be developed to use spray drying to produce nanoparticles that are much smaller in size than can be produced by any other means. This will enable the study of the unique properties of such small particles; in particular, the kinetic delay in crystallization due to their very small size. The work will be highly leveraged through interactions with industry, which provides intellectual challenges, employment for students and post docs and leverages NSF support. In addition, important technological advances will be used to establish start-up companies, which create new, high-quality technical jobs. The major educational component of this research will be training of graduate students and post docs. In addition, a highly successful outreach program, based on a Science and Cooking course, will be put online, reaching literally hundreds of thousands of participants, teaching them soft matter science through cooking.****Non-Technical Abstract****This research focuses on a general class of materials that are "soft," or easily deformable. Examples include many foods and personal care products, made of gels, surfactants or suspensions of small particles in a fluid, and even the cells that make up all living organisms. The research will explore important properties of these materials. For example, a major limitation of many food and personal care products is the long-term instability of the materials; the fundament origin of this will be explored and industrial production of the materials will be enhanced. A new control parameter for cells will be developed that will offer new insight into their behavior, particularly when they malfunction, such as occurs in many diseases. New devices will be created to produce particles that are much smaller than can be produced by any other means, and that will enhance the bioavailability of many newly developed drugs. The work will be highly leveraged through interactions with industry, providing an important outlet for technical advances, while offering employment opportunities to the students and post docs whose training is supported by this research. In addition, this research will lead to the formation of start-up companies which create new, high-quality jobs. For example, previous NSF funding has led to formation of 4 start-up companies which have created more than 120 new jobs, enhancing our nation's economy. As outreach to bring science to the general public, a science course, based on cooking, will be offered online by the PI through Harvard, with several hundred thousand participants expected.

**** 技术摘要 **** 拟议的研究集中在软物质物理学的三个主要主题：将研究耗尽吸引力形成的胶体凝胶的性质。这些信息将有助于解释延迟坍塌的起源，延迟坍塌是使用这种凝胶稳定商业产品的主要障碍。在生物物理学的努力中，将探索通过细胞体积控制细胞刚度。如果初步结果被证明是正确的，这将是我们对细胞特性的理解的一个转变。最后，将开发新的微流体装置，使用喷雾干燥来生产尺寸比任何其他方法都要小得多的纳米颗粒。这将使研究这种小颗粒的独特性质成为可能;特别是，由于它们非常小的尺寸，结晶的动力学延迟。这项工作将通过与工业界的互动得到高度利用，工业界为学生和博士后提供智力挑战、就业机会，并利用NSF的支持。此外，重要的技术进步将被用于建立初创公司，创造新的高质量的技术工作。本研究的主要教育组成部分将是研究生和博士后的培养。此外，一个非常成功的推广计划，基于科学和烹饪课程，将放在网上，达到数十万参与者，通过烹饪教他们软物质科学。非技术摘要 * 本研究主要关注“软”或易变形的一般材料。例子包括许多食品和个人护理产品，由凝胶，表面活性剂或液体中的小颗粒悬浮液制成，甚至是构成所有生物体的细胞。这项研究将探索这些材料的重要特性。例如，许多食品和个人护理产品的一个主要限制是材料的长期不稳定性;将探索这一问题的根本原因，并加强材料的工业生产。将开发一种新的细胞控制参数，这将为它们的行为提供新的见解，特别是当它们发生故障时，例如在许多疾病中发生。新的装置将被创造出来，以产生比任何其他方法都要小得多的颗粒，这将提高许多新开发药物的生物利用度。这项工作将通过与行业的互动得到高度利用，为技术进步提供重要的出路，同时为学生和博士后提供就业机会，他们的培训得到了这项研究的支持。此外，这项研究将导致初创公司的形成，创造新的，高质量的就业机会。例如，之前的NSF资助已经导致了4家初创公司的成立，创造了120多个新的就业机会，增强了我们国家的经济。作为将科学带给公众的推广活动，PI将通过哈佛在线提供一门基于烹饪的科学课程，预计将有数十万人参加。

项目成果

Single-step assembly of asymmetric vesicles

• DOI: 10.1039/c8lc00882e
• 发表时间: 2019-03-07
• 期刊: LAB ON A CHIP
• 影响因子: 6.1
• 作者: Arriaga, Laura R.;Huang, Yuting;Weitz, David A.
• 通讯作者: Weitz, David A.

Membrane-Integrated Glass Capillary Device for Preparing Small-Sized Water-in-Oil-in-Water Emulsion Droplets

• DOI: 10.1021/acs.langmuir.5b01514
• 发表时间: 2015-06-30
• 期刊: LANGMUIR
• 影响因子: 3.9
• 作者: Akamatsu, Kazuki;Kanasugi, Shosuke;Weitz, David A.
• 通讯作者: Weitz, David A.

Chemically induced coalescence in droplet-based microfluidics

• DOI: 10.1039/c4lc01285b
• 发表时间: 2015-01-01
• 期刊: LAB ON A CHIP
• 影响因子: 6.1
• 作者: Akartuna, Ilke;Aubrecht, Donald M.;Weitz, David A.
• 通讯作者: Weitz, David A.