DISSERTATION RESEARCH: Bacterial-symbiont-mediated competitive interactions among entomopathogenic nematodes

论文研究：细菌共生体介导的昆虫病原线虫之间的竞争性相互作用

• 批准号: 1310985
• 负责人: Heidi Goodrich-Blair
• 金额: $ 1.4万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1310985&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Bacterial; symbiont; mediated

The negative effects of individual species of parasites on animals have been intensively studied and can be very strong. Many animals are infested by multiple species of parasites, some of which have symbiotic microorganisms, but we know relatively little about how the interactions between parasites and their symbionts within a host may reduce or exacerbate the effects of parasitism. This project will investigate the interactions between two species of nematodes that parasitize insects and a bacterial symbiont of one of these species. Researchers will infect an insect host with nematodes, bacteria, or both to test the effect of the bacteria on the ability of the nematodes to reproduce. To investigate the underlying mechanisms, chemicals produced within the host in the different treatments will be compared for ability to induce responses in the bacteria and to inhibit the growth of the parasites. The results will broaden our knowledge of the role of parasites in natural systems and how they affect the health of animals. Previous studies have shown that bacteria within a host can influence the performance of parasites and even prevent them from successfully reproducing. This project will add to this promising new avenue for preventing or controlling parasitism. Research will also develop the parasite-bacteria system as a tool for teaching K-12 students, and train a Ph.D. student.

个别寄生虫对动物的负面影响已得到深入研究，而且可能非常严重。许多动物被多种寄生虫感染，其中一些寄生虫具有共生微生物，但我们对宿主内寄生虫及其共生体之间的相互作用如何减少或加剧寄生的影响知之甚少。本项目将研究寄生昆虫的两种线虫和其中一种细菌共生体之间的相互作用。研究人员将用线虫、细菌或两者同时感染昆虫宿主，以测试细菌对线虫繁殖能力的影响。为了研究潜在的机制，将比较不同处理下宿主体内产生的化学物质在细菌中诱导反应和抑制寄生虫生长的能力。研究结果将扩大我们对寄生虫在自然系统中的作用以及它们如何影响动物健康的认识。以前的研究表明，宿主内的细菌可以影响寄生虫的行为，甚至阻止它们成功繁殖。该项目将为预防或控制寄生虫病提供新的途径。研究还将开发寄生虫-细菌系统，作为K-12学生的教学工具，并培养一名博士生。