DISSERTATION RESEARCH: Blood meal source as an ecological determinant of bacterial community dynamics in the tick vector AMBLYOMMA AMERICANUM
论文研究:血粉来源作为蜱虫媒介 AMBLYOMMA AMERICANUM 中细菌群落动态的生态决定因素
基本信息
- 批准号:1311450
- 负责人:
- 金额:$ 2.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-06-01 至 2014-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A key obstacle to understanding the ecology of tick-borne diseases is the identification of the specific vertebrate animals, or hosts, on which ticks feed. Each host is potentially important because different species contain different combinations of nutrients, immune system molecules, and microbes that can affect pathogen transmission by the ticks. This doctoral dissertation improvement project will adapt existing molecular techniques to amplify trace remains of DNA from previous tick blood meals in order to determine past host use. Gene sequencing methods will then be used to determine the effect of prior hosts on the composition of bacterial communities in host-seeking ticks. This information will help to explain variation in bacterial communities among ticks and to predict the abundance and distribution of infectious ticks in the environment. Assay development and testing will use the lone star tick, the most common tick biting humans and animals in two thirds of the continental USA. It is the known vector of several human and veterinary pathogens and the carrier of many other bacteria whose significance in disease transmission is not well understood.Development of a new approach to blood meal analysis will provide a valuable tool to all researchers who study the ecology of blood-feeding arthropods, such as many medically and economically important tick species. The assay improves efficiency by exploiting recent advances in DNA sequencing technology to establish and increase sample throughput. The project will train undergraduate students in field and laboratory research involving both ecological and molecular methods. Finally, the researchers present their results to the staff and visitors to several Georgia state parks.
了解蜱传疾病的生态学的一个关键障碍是确定蜱赖以为生的特定脊椎动物或宿主。每个宿主都有潜在的重要性,因为不同的物种含有不同的营养物质、免疫系统分子和微生物组合,这些组合可以影响蜱虫传播病原体。这个博士论文改进项目将采用现有的分子技术来扩增以前蜱虫血餐的DNA痕迹,以确定过去的宿主使用。基因测序方法将用于确定先前宿主对寻找宿主蜱细菌群落组成的影响。这一信息将有助于解释蜱中细菌群落的变化,并预测环境中感染性蜱的丰度和分布。试验开发和测试将使用孤星蜱,最常见的蜱叮咬人类和动物在美国大陆的三分之二。它是几种人类和兽医病原体的已知媒介,也是许多其他细菌的携带者,这些细菌在疾病传播中的意义尚不清楚。一种新的血粉分析方法的发展将为所有研究吸血节肢动物生态学的研究人员提供一个有价值的工具,例如许多医学和经济上重要的蜱类。该分析通过利用DNA测序技术的最新进展来提高效率,以建立和增加样品吞吐量。该项目将培养本科生进行涉及生态学和分子方法的实地和实验室研究。最后,研究人员向乔治亚州几个州立公园的工作人员和游客展示了他们的研究结果。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Thomas Gillespie其他文献
Biogeography of fire regimes in western U.S. conifer forests: A trait‐based approach
美国西部针叶林火灾状况的生物地理学:基于特征的方法
- DOI:
10.1111/geb.13079 - 发表时间:
2020 - 期刊:
- 影响因子:6.4
- 作者:
J. T. Stevens;M. Kling;D. Schwilk;J. Kane;Thomas Gillespie - 通讯作者:
Thomas Gillespie
The impact of comorbidities and surgical approach in incisional hernia development after minimally invasive cholecystectomy: a systematic review and meta-analysis of multivariate regression-adjusted studies
- DOI:
10.1007/s10029-025-03340-9 - 发表时间:
2025-04-23 - 期刊:
- 影响因子:2.400
- 作者:
Caitlyn Voth;Nisha Kapani;Carlos Balthazar da Silveira;Laura Cogua;Nicole Salevitz;Vikram Deka;Thomas Gillespie;Conrad Ballecer - 通讯作者:
Conrad Ballecer
Obituary: Siv Aina Jensen Leendertz (Born Siv Aina Jensen: 1973–2018)
- DOI:
10.1007/s10764-018-0071-5 - 发表时间:
2018-11-20 - 期刊:
- 影响因子:1.800
- 作者:
Chantal Akoua-Koffi;Sandra Beermann;Sébastien Calvignac-Spencer;Emmanuel Couacy-Hymann;Helene De Nys;Bernhard Ehlers;Thomas Gillespie;Jeffrey Gilbert;Jan F. Gogarten;Sandra J. Laney;Felix Lankester;Fabian H. Leendertz;Benjamin Makepeace;Andreas Nitsche;Georg Pauli;Maude Pauly;Eystein Skjerve;Daniel Stern;Roma Thamm;Dominic Travis;Steve Unwin;Roman Wittig;Livia Wittiger - 通讯作者:
Livia Wittiger
Thomas Gillespie的其他文献
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{{ truncateString('Thomas Gillespie', 18)}}的其他基金
Doctoral Dissertation Research: Active and Passive Remote Sensing for Predicting Tropical Tree Species Richness across Spatial Scales
博士论文研究:主动和被动遥感预测跨空间尺度的热带树种丰富度
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1333701 - 财政年份:2013
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$ 2.01万 - 项目类别:
Standard Grant
Remote Sensing, Biogeography, and Conservation of Tropical Dry Forests in Pacific Biodiversity Hotspots
太平洋生物多样性热点地区热带干燥森林的遥感、生物地理学和保护
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0455052 - 财政年份:2005
- 资助金额:
$ 2.01万 - 项目类别:
Standard Grant
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