CPS: Breakthrough: A Cyber-Physical Framework for Magnetic Resonance Imaging (MRI) Guided Magnetic NanoParticles
CPS:突破:磁共振成像 (MRI) 引导磁性纳米粒子的网络物理框架
基本信息
- 批准号:1329649
- 负责人:
- 金额:$ 50万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-10-01 至 2017-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project investigates a new type of cyber-physical system (CPS), comprising magnetic nanoparticles in a fluidic environment such as human tissue whose motion is controlled by a computer via a magnetic field. The research aims to develop computational and experimental tools to perform the dynamic modeling, closed loop control and experimental validation of such a system of nanoparticles under guidance and observation using a magnetic resonance imaging (MRI) environment. The envisioned CPS infrastructure is composed of a new computational platform to perform 3D simulation, visualization and post-processing analysis of the aggregation and disaggregation process of magnetic nanoparticles within a fluidic environment like the small arteries and arterioles or fluid-filled cavities of the human body. It also includes the development of robust control algorithms for the guidance of a swarm of magnetic nanoparticles in a MRI environment. Experimental validation is to be performed in clinical MRI scanners and in customized laboratory test-beds that generate controllable magnetic fields able to move magnetic nanoparticles in fluidic environments. Potential applications of this basic research include nano-robotic drug delivery systems, composed of a system of magnetic nanoparticles guided by MRI scanners for targeted drug delivery in the human body. The project integrates education through participation of graduate and undergraduate students in the research, and involvement of the PI and graduate students in several outreach activities for students in high and middle schools.
该项目研究了一种新型的网络物理系统(CPS),包括流体环境中的磁性纳米颗粒,例如人体组织,其运动由计算机通过磁场控制。该研究旨在开发计算和实验工具,以使用磁共振成像(MRI)环境在指导和观察下对这种纳米颗粒系统进行动态建模,闭环控制和实验验证。 设想的CPS基础设施由一个新的计算平台组成,用于对流体环境中磁性纳米颗粒的聚集和解聚过程进行3D模拟,可视化和后处理分析,如人体的小动脉和小动脉或充满流体的空腔。它还包括在MRI环境中指导一群磁性纳米颗粒的鲁棒控制算法的开发。 实验验证将在临床MRI扫描仪和定制的实验室测试台中进行,这些测试台产生能够在流体环境中移动磁性纳米颗粒的可控磁场。 这项基础研究的潜在应用包括纳米机器人药物递送系统,该系统由MRI扫描仪引导的磁性纳米颗粒系统组成,用于人体内的靶向药物递送。 该项目通过研究生和本科生参与研究,以及PI和研究生参与高中和初中学生的几项推广活动,将教育纳入其中。
项目成果
期刊论文数量(0)
专著数量(0)
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专利数量(0)
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Randall Erb其他文献
Evaluation of two nitroglycerin dosage forms: A metered spray and a soft gelatin capsule
- DOI:
10.1007/bf01059060 - 发表时间:
1983-12-01 - 期刊:
- 影响因子:2.800
- 作者:
Randall Erb;William Stoltman - 通讯作者:
William Stoltman
Randall Erb的其他文献
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{{ truncateString('Randall Erb', 18)}}的其他基金
EAGER: Dispersion and Selective Positioning of Reinforcement in Polymer Matrix Composites
EAGER:聚合物基复合材料中增强材料的分散和选择性定位
- 批准号:
1445261 - 财政年份:2014
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
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