Collaborative Research: Dynamics of Miscible Jets and Drops

合作研究:混相射流和液滴的动力学

基本信息

  • 批准号:
    1335666
  • 负责人:
  • 金额:
    $ 18.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-10-01 至 2016-09-30
  • 项目状态:
    已结题

项目摘要

1335632/1335666 PI: Fuller/ShenThe translation of miscible jets and drops, and the dissolution of drops are common events encountered in numerous technological processes. It is critical to understand the evolution of the transient interfacial tension, which has eluded measurement. These challenges motivated methods recently demonstrated by the PIs groups to extract very small and transient interfacial tensions existing between miscible liquids. This collaborative research aims to develop a series of complementary experiments to understand the fluid dynamics of miscible pairs of liquids, which can interact with one another through various formats: miscible jets, miscible suspended droplets, and miscible sessile drops. These experiments will be supplemented by numerical simulations in collaboration with Professor Anderson of Eindhoven Technical University. Each of these multiphase flow systems result in outcomes that are qualitatively different from those encountered by immiscible liquid pairs. The specific aims are: (1) studies of drop and jets translating through a second, miscible liquid; (2) suspended droplets of a miscible liquid experiencing stagnation point extensional flow in a microfluidic environment; (3) sessile drops of a miscible liquid spreading and dissolving within a matrix liquid; and (4) diffuse interface simulation of miscible pendant drops, jets and sessile drops. The results from the modeling will be compared against experimental determinations of the interfacial shapes in jets and drops.The dynamics of miscible liquid pairs has received little previous attention but are central to many physical processes. The combination of miscible materials can produce stable, intricate morphologies that are not possible with immiscible mixtures. Jets of miscible liquids can be used to great advantage in the scale-up production of highly oriented fibers that are otherwise difficult to process. The dissolution of miscible, sessile drops is a rich problem in multiphase flow that offers interesting analogies to desiccating drops along with the possibility of extracting measures of the interfacial tension between miscible liquids. The microfluidic approach to measuring interfacial tensions can be applied to other physical problems, such as systems undergoing chemical reactions, where the interfacial tension is changing with time. Similar approaches can also be adapted to incorporate different types of miscible fluids, drops, and biomolecules. The project will provide research training to graduate and undergraduate students. The results developed in this program will also make wonderful teaching tools for the introduction of fluid mechanics and interfacial phenomena to high school and undergraduate students.
1335632/1335666 PI:Fuller/Shen 可混溶射流和液滴的转换以及液滴的溶解是许多技术过程中遇到的常见事件。了解瞬态界面张力的演变至关重要,因为瞬态界面张力一直无法测量。这些挑战激发了 PI 小组最近展示的方法,以提取存在于混溶液体之间的非常小且短暂的界面张力。这项合作研究旨在开发一系列互补实验,以了解可混溶液体对的流体动力学,这些液体可以通过各种形式相互作用:混溶射流、混溶悬浮液滴和混溶固着液滴。这些实验将得到与埃因霍温技术大学安德森教授合作的数值模拟的补充。这些多相流系统中的每一个所产生的结果与不混溶液体对所遇到的结果在性质上有所不同。具体目标是:(1)研究通过第二种可混溶液体的液滴和射流的平移; (2)在微流体环境中经历驻点拉伸流动的可混溶液体的悬浮液滴; (3)可混溶液体的固滴在基质液体中扩散和溶解; (4)可混溶悬滴、射流和座滴的扩散界面模拟。建模结果将与射流和液滴中界面形状的实验测定结果进行比较。可混溶液体对的动力学以前很少受到关注,但它是许多物理过程的核心。互溶材料的组合可以产生稳定、复杂的形态,这是不互溶混合物不可能实现的。在高取向纤维的放大生产中,使用可混溶液体的射流可以发挥巨大的优势,否则这些纤维很难加工。易混溶、固着液滴的溶解是多相流中的一个丰富问题,它提供了与干燥液滴有趣的类比以及提取可混溶液体之间界面张力的测量的可能性。测量界面张力的微流体方法可以应用于其他物理问题,例如正在进行化学反应的系统,其中界面张力随时间变化。类似的方法也可以适用于合并不同类型的可混溶流体、液滴和生物分子。该项目将为研究生和本科生提供研究培训。该项目的研究成果也将为高中生和本科生介绍流体力学和界面现象提供精彩的教学工具。

项目成果

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Amy Shen其他文献

Characterization of Recombinantly-Expressed Hydrolytic Enzymes from Chinese Hamster Ovary Cells: Identification of Host Cell Proteins that Degrade Polysorbate.
中国仓鼠卵巢细胞重组表达的水解酶的表征:降解聚山梨酯的宿主细胞蛋白的鉴定。
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Daniel Kovner;Inn H. Yuk;Amy Shen;Hong Li;Tobias Graf;Sanjay Gupta;Wenqiang Liu;A. Tomlinson
  • 通讯作者:
    A. Tomlinson
Recombinant adeno‐associated virus production evaluation in Chinese hamster ovary cells
中国仓鼠卵巢细胞中重组腺相关病毒的生产评估
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Thu M Cao;Dayue Chen;Gavin C Barnard;Amy Shen
  • 通讯作者:
    Amy Shen
Complete Knockout of the Lactate Dehydrogenase A Gene is Lethal in Pyruvate Dehydrogenase Kinase 1, 2, 3 Down-Regulated CHO Cells
乳酸脱氢酶 A 基因的完全敲除在丙酮酸脱氢酶激酶 1、2、3 下调的 CHO 细胞中是致命的
  • DOI:
    10.1007/s12033-014-9762-0
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    S. Yip;Meixia Zhou;J. Joly;B. Snedecor;Amy Shen;Y. Crawford
  • 通讯作者:
    Y. Crawford
High Intracellular Seed Train BiP Levels Correlate With Poor Production Culture Performance in CHO Cells.
高细胞内种子培养 BiP 水平与 CHO 细胞中不良的生产培养性能相关。
  • DOI:
    10.1002/biot.201700746
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Meg Tung;D. Tang;Szu;D. Zhan;Karen Kiplinger;Shu Pan;Yifeng Jing;Amy Shen;Patrick Ahyow;B. Snedecor;M. Gawlitzek;S. Misaghi
  • 通讯作者:
    S. Misaghi
Evaluation of heavy chain C‐terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells
重链 C 末端缺失对中国仓鼠卵巢 (CHO) 细胞中单克隆抗体生产率和产品质量的评估
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Zhilan Hu;D. Tang;S. Misaghi;Guoying Jiang;Christopher Yu;Mandy Yim;David Graeme Shaw;B. Snedecor;Michael W. Laird;Amy Shen
  • 通讯作者:
    Amy Shen

Amy Shen的其他文献

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{{ truncateString('Amy Shen', 18)}}的其他基金

Collaborative Research: Laser Treated Sol-Gel Glass for Ultra-High-Quality Photonic Devices
合作研究:用于超高品质光子器件的激光处理溶胶-凝胶玻璃
  • 批准号:
    0907638
  • 财政年份:
    2009
  • 资助金额:
    $ 18.66万
  • 项目类别:
    Standard Grant
Collaborative Research: MPSA-ENG: Interplay of Biosensing and Locomotion in Confined Microfluidic Environments
合作研究:MPSA-ENG:受限微流体环境中生物传感和运动的相互作用
  • 批准号:
    0852753
  • 财政年份:
    2008
  • 资助金额:
    $ 18.66万
  • 项目类别:
    Standard Grant
CAREER: Confinement and flow effects on synthesis of sol-gel materials
职业:限制和流动对溶胶-凝胶材料合成的影响
  • 批准号:
    0852471
  • 财政年份:
    2008
  • 资助金额:
    $ 18.66万
  • 项目类别:
    Standard Grant
CAREER: Confinement and flow effects on synthesis of sol-gel materials
职业:限制和流动对溶胶-凝胶材料合成的影响
  • 批准号:
    0645062
  • 财政年份:
    2007
  • 资助金额:
    $ 18.66万
  • 项目类别:
    Standard Grant
Collaborative Research: MPSA-ENG: Interplay of Biosensing and Locomotion in Confined Microfluidic Environments
合作研究:MPSA-ENG:受限微流体环境中生物传感和运动的相互作用
  • 批准号:
    0700830
  • 财政年份:
    2007
  • 资助金额:
    $ 18.66万
  • 项目类别:
    Standard Grant
Collaborative Research: Self-Powered Sensory Nerve System for Civil Structures Using Hybrid Forisome Actuators
合作研究:使用混合 Forisome 执行器的土木结构自供电感觉神经系统
  • 批准号:
    0510941
  • 财政年份:
    2005
  • 资助金额:
    $ 18.66万
  • 项目类别:
    Standard Grant
NER: High Throughput Manufacturing of Nanoporous Films via Flow-Induced Micelle Alignment
NER:通过流动诱导胶束排列高通量制造纳米多孔薄膜
  • 批准号:
    0404243
  • 财政年份:
    2004
  • 资助金额:
    $ 18.66万
  • 项目类别:
    Standard Grant
Biomimetic Smart Materials and Sensors
仿生智能材料和传感器
  • 批准号:
    0437236
  • 财政年份:
    2004
  • 资助金额:
    $ 18.66万
  • 项目类别:
    Standard Grant

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合作研究:BoCP-实施:高山植物作为变暖世界中生物多样性动态的模型系统:整合遗传、功能和社区方法
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