MRI: Development of an Integrated Image-guided Thermal Therapy Platform

来自堪萨斯州立大学三个学院的五名研究人员将通过设计射频（RF）热疗单元并将其集成到600 MHz NMR Bruker AVANCE IIITM高性能数字NMR光谱仪中，开发一个完全集成的图像引导热疗平台。Stefan Bossmann（化学）将担任此项奋进的协调PI。拟议的仪器将是第一个高场（14 T）系统能够成像的生理效应和温度分布在小动物在射频热疗治疗。这将允许以前所未有的灵敏度在细胞介导疗法中靶向、监测和反馈控制纳米颗粒增强的射频热疗。由于NMR和磁共振成像设备的技术相似性，所产生的技术最终将使个性化的热疗治疗成为可能，用于治疗动物和人类的传染病和癌症。开发人员团队的高度跨学科性质将促进工程，艺术和科学以及兽医学院之间的快速技术转移。 虽然热疗在治疗许多疾病方面具有巨大的潜力，但由于技术障碍，其全部潜力尚未被开发。完全集成的图像引导热疗平台将为热疗作为单一疗法以及与其他疗法（如细胞疗法或放射疗法）协同使用提供一种直接的方法。热疗平台将通过参与的学院、堪萨斯大学癌症中心（UKCC）、特里C。堪萨斯州的约翰逊癌症中心、堪萨斯州的纳米技术创新中心（www.NICKS.edu）和堪萨斯州的美国国土安全部新发和人畜共患动物疾病卓越中心（CEEZAD，http：//www.ceezad.org/）。与国家生物和农业防御设施（NBAF）的合作将在其投入运营后开始。

Bossmann1337438A team of five investigators from three colleges of Kansas State University will develop a fully integrated image-guided thermal therapy platform by designing a radio-frequency (RF-) hyperthermia unit and integrating it into a 600MHz NMR Bruker AVANCE IIITM High Performance Digital NMR Spectrometer. Stefan Bossmann (Chemistry) will serve as coordinating PI of this endeavor. The proposed instrumentation will be the first high field (14 T) system capable of imaging the physiological effects and temperature distribution in small animals during RF-hyperthermia treatment. This will permit targeting, monitoring and feedback-control of nanoparticle-enhanced RF hyperthermia in cell-mediated therapies with unprecedented sensitivity. Due to the technical similarities of NMR and Magnetic Resonance Imaging devices, the resulting technology will eventually enable personalized hyperthermia treatment for treating infectious diseases and cancers in animals and humans. The highly interdisciplinary nature of the team of developers will facilitate rapid technology transfer between the Colleges of Engineering, Arts and Sciences and Veterinary Medicine. Although hyperthermia has great potential for the treatment of numerous disorders, its full potential has not been explored because of technical obstacles. A fully integrated image-guided thermal therapy platform will provide atraightforward approach to the utilization of hyperthermia as monotherapy and in synergy with other therapies, such as cytotherapy or radiation therapy. The thermal therapy platform will be made available to the research community through the participating colleges, the University of Kansas Cancer Center (UKCC), the Terry C. Johnson Cancer Center at Kansas State, the Nanotechnology Innovation Center of Kansas State (www.NICKS.edu), and the U.S. Department of Homeland Security Center of Excellence for Emerging and Zoonotic Animal Diseases (CEEZAD, http://www.ceezad.org/) at Kansas State. Collaboration with The National Bio- and Agro-Defense Facility (NBAF) will begin as soon as it is operational.