Development of the integrated method for the analysis of brain function by high resolution PET for small animals with the aid of high field MRI

开发高场MRI辅助小动物高分辨率PET脑功能分析综合方法

• 批准号: 23591752
• 负责人: MOMOSE Toshimitsu
• 金额: $ 3.33万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591752/
• 关键词: micro-PET; high field MRI; small animal; brain imaging; molecular imaging; anatomical normalization; PET-CT; mouse; PET; 小動物; マウス; MRI; 解剖学的情報; FDG; CT; microPET; 脳解剖; 糖代謝; 脳機能; fusion

The high-resolution PET for small animals is expected to be one of the important tools for the elucidation of the pathophysiology and the innovative drug development of the disease. In this study, we tried to develop the system which enables us to analyze molecular target imaging by micro-PET using high-field MRI. Using a new head fixation device for mouse which can be used commonly both for micro-PET and high-field MRI for small animals, we underwent both MRI and FDG-PET of C57BL mice and made an anatomical delineation on micro-PET imaging after normalization of MRI of each mouse to standard mouse brain atlas. We were able to superimpose a functional image of FDG-PET on an anatomical atlas and calculate regional uptake of FDG over global mean brain uptake. We have found that there was a good correlation between automated method and manual method. It is concluded that automated regional analysis can be applied to the FDG-PET imaging of normal and transgenic mouse brain.

小动物的高分辨率PET有望成为阐明该病病理生理学和创新药物开发的重要工具之一。 在这项研究中，我们试图开发的系统，使我们能够分析分子靶成像的micro-PET使用高场MRI。 利用一种可用于小动物micro-PET和高场MRI的新型小鼠头部固定装置，对C57 BL小鼠进行了MRI和FDG-PET检查，并将每只小鼠的MRI标准化为标准小鼠脑图谱后，在micro-PET成像上进行解剖学勾画。我们能够在一个解剖图集上显示FDG-PET的功能图像，并计算出FDG的区域摄取超过全球平均脑摄取。我们发现自动化方法和人工方法之间有很好的相关性。结论：自动区域分析可应用于正常和转基因小鼠脑的FDG-PET成像。

项目成果

中外医学社

中外医学社

• 发表时间: 2022
• 作者: 椎名達郎;吉川遼;西川大生;宮地洋希;桐山大輝;川端野乃子;今崎剛;仁田亮;仁田英里子;沼田晃彦
• 通讯作者: 沼田晃彦

Prediction of outcomes in MCI with (123)I-IMP-CBF SPECT: a multicenter prospective cohort study.

• DOI: 10.1007/s12149-013-0768-7
• 发表时间: 2013-12
• 期刊: ANNALS OF NUCLEAR MEDICINE
• 影响因子: 2.6
• 作者: Ito, Kengo;Mori, Etsuro;Fukuyama, Hidenao;Ishii, Kazunari;Washimi, Yukihiko;Asada, Takashi;Mori, Satoru;Meguro, Kenichi;Kitamura, Shin;Hanyu, Haruo;Nakano, Seigo;Matsuda, Hiroshi;Kuwabara, Yasuo;Hashikawa, Kazuo;Momose, Toshimitsu;Uchida, Yoshitaka;Hatazawa, Jun;Minoshima, Satoshi;Kosaka, Kenji;Yamada, Tatsuo;Yonekura, Yoshiharu
• 通讯作者: Yonekura, Yoshiharu