Development of the integrated method for the analysis of brain function by high resolution PET for small animals with the aid of high field MRI

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The high-resolution PET for small animals is expected to be one of the important tools for the elucidation of the pathophysiology and the innovative drug development of the disease. In this study, we tried to develop the system which enables us to analyze molecular target imaging by micro-PET using high-field MRI. Using a new head fixation device for mouse which can be used commonly both for micro-PET and high-field MRI for small animals, we underwent both MRI and FDG-PET of C57BL mice and made an anatomical delineation on micro-PET imaging after normalization of MRI of each mouse to standard mouse brain atlas. We were able to superimpose a functional image of FDG-PET on an anatomical atlas and calculate regional uptake of FDG over global mean brain uptake. We have found that there was a good correlation between automated method and manual method. It is concluded that automated regional analysis can be applied to the FDG-PET imaging of normal and transgenic mouse brain.