MRI: Development of multi-parametric/multimodal spectroscopy (MPMS) apparatus for characterization of functional interfaces

随着对功能界面的兴趣日益增加，以定量的方式表征表面上的化学结构和生物分子，并测试它们的适当分配方向、构象、活性、稳定性，该提案将通过整合几种协同表面表征光谱方法，例如表面等离子体，荧光和电化学光谱到一个新的表面分析系统。虽然将所有这些技术结合起来的理由很简单，但目前还没有这样的工具。该提案的主要目标是开发一个多参数/多模态光谱（MPMS）系统，同时应用表面介导的光学和电化学技术。建议的MPMS系统，它结合了三种光谱技术，将促进新的定量见解的相互作用范围广泛的化学和生物物种与合理设计的接口。通过协同传感技术的组合，这种新方法可以克服当前广泛使用的表面表征技术的几个关键限制。

1337818SimonianWith increasing interest in functional interfaces, it becomes increasingly important to characterize chemical structures and biomolecules on surfaces in a quantitative fashion, and to test their proper allocation orientation, conformation, activities, stability, etc. This proposal will enhance the power and capabilities of interface characterization sensing techniques by integrating several synergistic surface characterization spectroscopy methods such as surface plasmon,fluorescence, and electrochemical spectroscopies into one new surface analytic system. Although the reasoning for combining all of these techniques is straightforward, currently there is no such instrument available. The main objective of this proposal is to develop a multi-parametric/multimodal spectroscopy (MPMS) system for simultaneous application of surface-mediated optical and electrochemical techniques The proposed MPMS system, which combines three spectroscopic techniques, will facilitate new quantitative insights into the interactions of a broad range of chemical and biological species with rationally designed interfaces. Through the combination of synergistic sensing techniques, this new approach can overcome several key limitations of current, widely-used surface characterization technologies.