MRI: Acquisition of a Spectropolarimeter

MRI：获取分光偏振计

• 批准号: 1337781
• 负责人: Ellen Moomaw
• 金额: $ 10.3万
• 依托单位: Kennesaw State University Research and Service Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1337781&HistoricalAwards=false
• 关键词: MRI; Acquisition; Spectropolarimeter

An award is made to Kennesaw State University for the purchase a spectropolarimeter and associated equipment for the use in multidisciplinary research and research training. Circular dichroism (CD) is an essential tool for the analysis of molecular conformations and is often used in the estimation of secondary structure in proteins. CD is a powerful probe of changes in protein conformations. It is possible, for example, to observe small changes in helical content using difference methods, and the effects of mutations and protein-protein interactions can be studied. The spectropolarimeter will be used initially by a core group of five laboratories at KSU and their collaborators. Dr. Ellen Moomaw's work focuses on structure/function relationships in bicupin oxalate oxidase. Dr. Michael Van Dyke investigates ligand-nucleic acid interactions. Dr. Carol Chrestensen studies the activity and regulation of mitogen activated protein kinase activated protein (MAPKAP) kinase 2 (MK2) involved in response to oxidative stress. Dr. Jonathan McMurry studies the type III secretion (T3S) mechanism involved in the assembly of the bacterial flagellum. Dr. John Salerno investigates catalysis and control in nitric oxide synthases (NOSs). The spectropolarimeter significantly enhances the research infrastructure at KSU. The equipment will be used primarily in research, including projects with undergraduate researchers. This equipment is also important to the nascent masters programs in Integrative Biology and Biochemistry at KSU. It is expected that these programs will complement and strengthen the demonstrated track record of undergraduate research participation and training at KSU. Involvement of the facility with course curricula is also planned. The initial user group has significant combined experience in mentoring undergraduate researchers. Each faculty member designs individual student-centered research projects that are carved out of the whole with well-defined goals and objectives giving each undergraduate researcher a good chance of completion in an appropriate time frame. This instrumentation will enhance the depth and breadth of opportunities that KSU faculty can offer their undergraduate researchers. The availability of advanced instrumentation is an important factor leading to the recruitment of KSU's best students into STEM careers. The instrument will enhance faculty and student opportunities to collaborate internationally and improve the visibility of the institution in the international marketplace. All members of the initial user group have strong track records of providing research opportunities to women and underrepresented minorities.

授予肯尼索州立大学一笔款项，用于购买一台分光偏振仪和相关设备，用于多学科研究和研究培训。圆二色性（CD）是分子构象分析的重要工具，常用于蛋白质二级结构的估计。CD是蛋白质构象变化的有力探针。例如，可以使用不同的方法观察螺旋含量的微小变化，并可以研究突变和蛋白质-蛋白质相互作用的影响。分光偏振仪最初将由KSU的五个实验室及其合作者组成的核心小组使用。Ellen Moomaw博士的工作重点是bicupin草酸氧化酶的结构/功能关系。Michael货车Dyke博士研究配体-核酸相互作用。Carol Chrestensen博士研究了参与氧化应激反应的丝裂原活化蛋白激酶活化蛋白（MAPKAP）激酶2（MK2）的活性和调节。Jonathan McMurry博士研究了参与细菌鞭毛组装的III型分泌（T3 S）机制。John萨莱诺博士研究一氧化氮合酶（NOS）的催化和控制。分光偏振仪显著增强了KSU的研究基础设施。这些设备将主要用于研究，包括本科研究人员的项目。这种设备也是重要的新生硕士课程在综合生物学和 KSU的生物化学。预计这些计划将补充和加强在KSU本科生的研究参与和培训的表现记录。还计划让该设施参与课程设置。初始用户组在指导本科研究人员方面具有重要的综合经验。每个教师都设计了以学生为中心的研究项目，这些项目是从整体中分割出来的，具有明确的目标和目的，使每个本科生研究人员有很好的机会在适当的时间内完成。这种仪器将提高KSU教师可以为本科研究人员提供的机会的深度和广度。先进仪器的可用性是导致KSU最好的学生进入STEM职业招聘的一个重要因素。该工具将提高教师和学生的国际合作机会，提高该机构在国际市场上的知名度。初始用户组的所有成员都有向妇女和代表性不足的少数群体提供研究机会的良好记录。