MRI: Acquisition of a Spectropolarimeter

向肯纳索州立大学授予购买光谱偏振仪和相关设备的奖励，用于多学科研究和研究培训。圆二色谱(CD)是分析分子构象的重要工具，常用于蛋白质二级结构的估算。CD是蛋白质构象变化的有力探针。例如，可以使用不同的方法观察螺旋含量的微小变化，并可以研究突变和蛋白质-蛋白质相互作用的影响。光谱偏振仪最初将由KSU的五个实验室及其合作者组成的核心小组使用。Ellen Moomaw博士的工作重点是Bipupin草酸氧化酶的结构/功能关系。迈克尔·范戴克博士研究配体与核酸的相互作用。卡罗尔·克里斯滕森博士研究了参与氧化应激反应的丝裂原活化蛋白激酶激活蛋白(MAPKAP)的活性和调控。乔纳森·麦克默里博士研究了参与细菌鞭毛组装的III型分泌(T3S)机制。John Salerno博士研究一氧化氮合酶(NOSS)的催化和控制。光谱偏振仪极大地加强了KSU的研究基础设施。这些设备将主要用于研究，包括与本科生研究人员合作的项目。这种设备对科罗拉多州立大学新兴的综合生物学和生物化学硕士项目也很重要。预计这些项目将补充和加强科罗拉多州立大学在本科生参与研究和培训方面的良好记录。还计划将该设施与课程课程结合起来。最初的用户群体在指导本科生研究人员方面有重要的组合经验。每个教员设计以学生为中心的个人研究项目，这些项目是从整体中划分出来的，有明确的目标和目的，给每个本科生研究人员在适当的时间框架内完成的很好的机会。这一工具将增强KSU教员为他们的本科生研究人员提供的机会的深度和广度。先进仪器的可获得性是导致KSU招聘最优秀的学生进入STEM职业生涯的一个重要因素。该工具将增加教职员工和学生进行国际合作的机会，并提高该机构在国际市场上的知名度。最初用户群体的所有成员在向妇女和代表性不足的少数群体提供研究机会方面都有良好的记录。

An award is made to Kennesaw State University for the purchase a spectropolarimeter and associated equipment for the use in multidisciplinary research and research training. Circular dichroism (CD) is an essential tool for the analysis of molecular conformations and is often used in the estimation of secondary structure in proteins. CD is a powerful probe of changes in protein conformations. It is possible, for example, to observe small changes in helical content using difference methods, and the effects of mutations and protein-protein interactions can be studied. The spectropolarimeter will be used initially by a core group of five laboratories at KSU and their collaborators. Dr. Ellen Moomaw's work focuses on structure/function relationships in bicupin oxalate oxidase. Dr. Michael Van Dyke investigates ligand-nucleic acid interactions. Dr. Carol Chrestensen studies the activity and regulation of mitogen activated protein kinase activated protein (MAPKAP) kinase 2 (MK2) involved in response to oxidative stress. Dr. Jonathan McMurry studies the type III secretion (T3S) mechanism involved in the assembly of the bacterial flagellum. Dr. John Salerno investigates catalysis and control in nitric oxide synthases (NOSs). The spectropolarimeter significantly enhances the research infrastructure at KSU. The equipment will be used primarily in research, including projects with undergraduate researchers. This equipment is also important to the nascent masters programs in Integrative Biology and Biochemistry at KSU. It is expected that these programs will complement and strengthen the demonstrated track record of undergraduate research participation and training at KSU. Involvement of the facility with course curricula is also planned. The initial user group has significant combined experience in mentoring undergraduate researchers. Each faculty member designs individual student-centered research projects that are carved out of the whole with well-defined goals and objectives giving each undergraduate researcher a good chance of completion in an appropriate time frame. This instrumentation will enhance the depth and breadth of opportunities that KSU faculty can offer their undergraduate researchers. The availability of advanced instrumentation is an important factor leading to the recruitment of KSU's best students into STEM careers. The instrument will enhance faculty and student opportunities to collaborate internationally and improve the visibility of the institution in the international marketplace. All members of the initial user group have strong track records of providing research opportunities to women and underrepresented minorities.