MRI: Acquisition of an integrated atomic force microscope/ Inverted optical microscope for interdisciplinary research at Cleveland State University

拟议的仪器将支持科罗拉多州立大学跨越五个学科（生物医学、化学、电气、物理和化学）的广泛前沿和创新研究项目。这种集成仪器对科罗拉多州立大学不断增长的核心教师具有重要价值，他们的研究组合包括：生物医学，电子和能源应用的新材料，生物传感器，热响应聚合物，纳米级系统，软材料的生物力学，以及生理条件下细胞/亚细胞特征的实时成像。将受益于广泛使用拟议设备的项目包括：(i)软材料的结构和机械性能，（ii）干细胞分化的机械转导效应，（iii）生物分子、生物材料和活细胞修饰的化学选择性和生物相容性化学表征，（iv）生物医学应用的细胞表面模拟分子的设计、合成和评估。(v)反应材料的功能分子构建块的表征，（vi）原生纤毛蛋白活细胞的图像分析，（vii）制备纳米结构射线的混合策略的表征，（viii）骨组织工程纳米纹理金属底物的表征，（ix）用于储氢的纳米多孔阳极氧化氧化铝模板和膜的研究，以及(x)提高固定化酶在生物电子应用中的稳定性。

1337859KothapalliThe proposed instrument will support a broad range of cutting-edge and innovative researchprojects spanning five disciplines (Biomedical, Chemical, Electrical, Physics and Chemistry)at CSU. This integrated instrument is of great value to a growing core of CSU facultywhose research portfolios encompass: novel materials for biomedical, electronics and energyapplications, biosensors, thermo-responsive polymers, nano-scale systems, biomechanics ofsoft materials, and live imaging of cellular/ sub-cellular features under physiological conditions.The projects that will benefit from extensive access to the proposed equipment include:(i) Structural and mechanical properties of soft materials, (ii) Mechanotransduction effectson stem cell differentiation, (iii) Characterization of chemically-selective and biocompatible-chemistryfor biomolecule, biomaterial and living-cell modifications, (iv) Design, synthesis and evaluationof cell-surface mimetic molecules for biomedical applications, (v) Characterization of functionalmolecular building blocks for responsive materials, (vi) Image analysis of primary ciliumin living cells, (vii) Characterization of hybrid strategies for fabrication of nanostructuredarrays, (viii) Characterization of nano-textured metallic substrates for bone tissue engineering,(ix) Investigation of nano-porous anodized alumina templates and membranes for hydrogen storage,and (x) Improving the stability of immobilized enzymes for bioelectronic applications.