MRI: Acquisition of a High Resolution Liquid Chromatograph Coupled to a High Resolution and High Mass Accuracy Ion Trap Time of Flight Mass Spectrometer

1338167 Christopher本提案旨在收购与Shimadzu四极杆离子阱飞行时间质谱仪（LCMS-IT-TOF？）耦合的Shimadzu Nexera高分辨率液相色谱仪。这种先进的设备是先进研究的关键资产，将最大限度地整合研究和教育，并加快能源和环境以及材料和制造领域的进展-这是SDSM T研究和开发的两个最优先事项。该仪器将填补SDSM T在研究基础设施和能力方面的关键空白，因为目前校园内没有这样的仪器。类似的LC/MS系统可在布鲁金斯的南达科他州州立大学和Vermillion的南达科他州大学获得，这两所大学都距离拉皮德城约400英里。拟议的设备将服务于校园内的大量部门和个人用户，并将成为精确分子量测量，反应监测，复杂化学和生物系统中杂质和目标化合物的鉴定和定量，小分子和大分子的快速筛选，氨基酸测序的蛋白质组学研究，酶的结构分析和定量的关键资产，LC/MS系统将用于校园内许多学科的研究，如化学，化学工程，生物/地质/化学，生物加工，微生物学，分子和应用生物学，生态系统，环境科学和工程以及材料工程。

1338167ChristopherThis proposal is for acquisition of a Shimadzu Nexera High Resolution Liquid Chromatograph Coupled to a Shimadzu Quadrupole Ion Trap Time-Of-Flight Mass Spectrometer (LCMS-IT-TOF?). This state of the art equipment is a critical asset for advanced research that will maximize the integration of research and education and accelerate progress in the areas of Energy and Environment and Materials and Manufacturing -two of the top priorities for research and development at SDSM&T. The instrument will fill a critical gap in research infrastructure and capabilities at SDSM&T as there is currently no such instrument on campus. Similar LC/MS systems are available at the South Dakota State University in Brookings and University of South Dakota in Vermillion, which are both approximately 400 miles away from Rapid City. The proposed equipment will serve a large number of departments and individual users across campus and will be a critical asset for accurate molecular mass measurements, reaction monitoring, identification and quantitation of impurities and target compounds in complex chemical and biological systems, rapid screening of small and large molecules, proteomics research for amino acid sequencing, structural analysis and quantitation of enzymes, etc. The LC/MS system will be used for research in a number of disciplines on campus such as chemistry, chemical engineering, bio/geo/chemistry, bioprocessing, microbiology, molecular and applied biology, ecosystems, environmental sciences and engineering, and materials engineering.