PDB Management by the Research Collaboratory for Structural Bioinformatics

新泽西州立大学罗格斯大学（Rutgers University of New Jersey）因管理蛋白质数据库（PDB）而获奖。蛋白质数据库是一个关于生物大分子结构的国际存储库和主要信息来源。PDB是一个重要的研究资源，对我们理解生命系统至关重要。它为实验、结构和计算科学家以及各级教育工作者提供广泛的服务。PDB访问通过主web和ftp站点（www.pdb.org, ftp.pdb.org）或通过分布在世界各地的多个镜像站点提供。PDB将由结构生物学研究合作实验室（RCSB）管理，RCSB由罗格斯大学、加州大学圣地亚哥分校和斯克里普斯海洋学研究所组成，为实验确定的大分子结构提供一个单一的、可搜索的、准确的、有充分注释的数据档案。RCSB开发的系统目前用于数据处理、存档、分发和查询，以及物理存档的维护。除了主要数据存档、接收和传播功能的持续运行之外，该项目还将实现对与存档的两个主要操作功能（数据接收和处理以及数据传播）相关的基础设施的若干增强。改进包括提供一个强大的、高吞吐量的管道，以管理提交给PDB的数据量和复杂性的持续增长，开发查询、分析、可视化和报告工具，以增强对PDB数据的访问，并开发一系列教育和推广活动，支持所有教育阶段的教师和学生使用PDB数据。这一努力的结果将是蛋白质数据库对专家和非专业人士的效用和价值的显著提高。增加这项工作更广泛影响的机制包括：一系列研讨会和会议，积极参与科学会议，定期通讯，持续使用帮助台来增加专家和非专业研究界对PDB的访问和效用，以及使用焦点小组来确保PDB数据的最大可用性。参与研究生和本科生课程的设计和实施以及结构化的研究机会正在被用来增加PDB对大学水平教育的影响。参加教师培训讲习班和开展教师发展计划的合作努力为将PDB资源引入K/12教育环境提供了机会。通过巡回艺术展览和频繁的新闻发布和信息节目，公众正在了解人民开发署的努力。在线活动，比如？生物学的结构观？然后呢?月度分子奖？将覆盖全国和全球的受众。根据目前的奖励，将开展的新活动包括增加对代表性不足的社区的接触，并制定年度主题，以便为涉及结构生物学的全国一体化教育活动提供重点。总的来说，这些努力将把开发计划署资源和活动的好处扩大到尽可能广泛的社区。

An award is made to Rutgers, the State University of New Jersey to manage the Protein Data Bank (PDB), an international repository and primary source for information about the structure of biological macromolecules. The PDB is a key research resource that is essential for our understanding of living systems. It serves a broad community of experimental, structural, and computational scientists, and educators at all levels. PDB access is provided through primary web and ftp sites (www.pdb.org, ftp.pdb.org) or via multiple mirror sites distributed worldwide. The PDB will be managed by the Research Collaboratory for Structural Biology (RCSB), consisting of a partnership between Rutgers, the University of California San Diego and the Scripps Institute of Oceanography to provide a single, searchable archive of accurate and well-annotated data on experimentally determined macromolecular structure. Systems developed by RCSB are currently being used for data processing, archiving, distribution and query, as well as maintenance of the physical archive. In addition to continued operation of the primary data archiving, ingestion, and dissemination functions, the project will implement several enhancements to the infrastructure associated with the two main operational functions of the archive: data ingestion and processing, and data dissemination. Improvements include provision of a robust, high-throughput pipeline to manage ongoing increases in the volume and complexity of data submitted to PDB, development of query, analysis, visualization, and reporting tools to enhance access to PDB data, and develop a range of education and outreach activities that support the use of PDB data by teachers and students at all educational stages. The result of this effort will be a significant improvement in the utility and value of the Protein Data Bank for both specialists and non-specialists alike. Mechanisms for increasing the broader impacts of this work include the following: a series of workshops and meeting sessions, active participation in scientific meetings, a regular newsletter, the on-going use of a help desk to increase the access and utility of PDB for the specialist and non-specialist research community, and use of focus groups to insure maximum usability of PDB data. Participation in graduate and undergraduate coursework design and implementation and in structured research opportunities is being used to increase the impact of PDB on university-level education. Participation in teacher training workshops and a collaborative effort to launch a teacher development program provide opportunities to bring PDB resources to the K/12 environment. The general public is being made aware of PDB efforts through a traveling art exhibit and through frequent news releases and informational programs. Online-based activities like the ?Structural View of Biology? and ?Molecule of the Month? will reach audiences nationally and globally. New activities to be introduced under the current award include increased outreach to under-represented communities and the development of annual theme topics to provide a focus for national integration of education activities involving structural biology. Collectively, these efforts will extend the benefits of PDB resources and activities to the broadest possible community.