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PDB Management by The Research Collaboratory for Structural Bioinformatics

结构生物信息学研究合作实验室的 PDB 管理

基本信息

批准号：
1832184
负责人：
Stephen Burley
金额：
$ 1450万
依托单位：
Rutgers University New Brunswick
依托单位国家：
美国
项目类别：
Cooperative Agreement
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1832184&HistoricalAwards=false
关键词：
PDB Management Research Collaboratory Structural

项目摘要

The mission of the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank (PDB) is to sustain a unique Findable-Accessible-Interoperable-Reusable (FAIR) living data resource of three-dimensional (3D) biomolecular structure information. PDB structures are the molecules of life. Knowledge of 3D structures (shapes) of biological macromolecules, how they evolved with time, and their functions are essential for understanding critical areas of science, including fundamental biology; health and disease of humans, animals, and plants; food and energy production; and other topics of concern to global prosperity and environmental sustainability. Structure data are equally important for biopharmaceutical and biotechnology companies, driving discovery of new therapeutics, biomaterials, and medical devices. RCSB PDB services span the entire PDB data lifecycle. Archive Management/Access services safeguard this single global archive of over 137,000 3D structures of biological macromolecules, with an estimated replacement cost of nearly $14 billion. Deposition/Biocuration and Data Exploration services support over 30,000 data contributors and over 1 million data users worldwide. The PDB has a 19-year history of scientific and technical leadership in sustaining an open-access global data resource that has become central to research and education in biology and medicine, by curating, integrating, and disseminating biomolecular structure information in the context of biological function, biochemical pathways, cellular processes, disease states, and molecular evolution. RCSB PDB websites supporting research (rcsb.org) and education (pdb101.rcsb.org) foster a molecular understanding of fundament biology, biomedicine, and energy in three-dimensions at the atomic level. Access to PDB data and RCSB PDB services will continue to drive patent applications, drug discovery and development, publication of innovative research, in scientific disciplines ranging from Agriculture to Zoology, development of life-changing biopharmaceutical products and formation of new US companies. RCSB PDB outreach, education, and training efforts leverage PDB data and RCSB PDB staff expertise. More than 620,000 researchers, educators, students, and members of the public use the Outreach/Education services. Online materials supporting exploration of fundamental biology; biomedicine; energy; biotechnology drug discovery; and Science, Technology, Engineering, and Mathematics (STEM) education, are consumed by researchers, educators, students, and the public. RCSB PDB educational resources are designed for global reuse in homes and classrooms, requiring only modest desktop computers, smartphones, or digital printers to experience the full impact of the project's online offerings. These free-of-charge materials are hosted at pdb101.rcsb.org, including the popular Molecule of the Month series that highlights the structure and function of molecules, and the Guide to Understanding PDB Data that introduces structural biology tools to a broad audience. RCSB PDB also produces and distributes online curricular materials for high school and college educators and students, explaining how molecular structures inform fundamental biology, medicine, energy, biotechnology, and drug discovery, with a focus on global public health concerns.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

结构生物信息学研究合作实验室（RCSB）蛋白质数据库（PDB）的使命是维持一个独特的三维（3D）生物分子结构信息的可发现-可解释-可互操作-可重用（FAIR）活体数据资源。 PDB结构是生命的分子。生物大分子的3D结构（形状），它们如何随时间演变及其功能的知识对于理解科学的关键领域至关重要，包括基础生物学;人类，动物和植物的健康和疾病;食品和能源生产;以及其他关注全球繁荣和环境可持续性的主题。结构数据对于生物制药和生物技术公司同样重要，可以推动新疗法、生物材料和医疗设备的发现。RCSB PDB服务跨越整个PDB数据生命周期。档案管理/访问服务保护着这个包含137，000多个生物大分子3D结构的单一全球档案，估计重置成本近140亿美元。沉积/生物定位和数据探索服务支持全球30，000多个数据贡献者和100多万数据用户。PDB在维持开放获取的全球数据资源方面拥有19年的科学和技术领导历史，该资源已成为生物学和医学研究和教育的核心，通过在生物功能，生化途径，细胞过程，疾病状态和分子进化的背景下策划，整合和传播生物分子结构信息。RCSB PDB网站支持研究（rcsb.org）和教育（pdb101.rcsb.org）促进对基础生物学，生物医学和原子水平三维能量的分子理解。PDB数据和RCSB PDB服务的访问将继续推动从农业到动物学等科学学科的专利申请、药物发现和开发、创新研究的出版、改变生活的生物制药产品的开发以及新美国公司的成立。RCSB PDB推广、教育和培训工作利用PDB数据和RCSB PDB工作人员的专业知识。超过620，000名研究人员，教育工作者，学生和公众使用外联/教育服务。支持基础生物学探索的在线材料;生物医学;能源;生物技术药物发现;科学，技术，工程和数学（STEM）教育，由研究人员，教育工作者，学生和公众消费。RCSB PDB教育资源专为家庭和教室的全球重用而设计，只需要普通的台式计算机，智能手机或数字打印机就可以体验该项目在线产品的全面影响。这些免费材料托管在pdb101.rcsb.org上，包括流行的每月分子系列，突出了分子的结构和功能，以及了解PDB数据的指南，向广大受众介绍了结构生物学工具。RCSB PDB还为高中和大学教育工作者和学生制作和分发在线课程材料，解释分子结构如何为基础生物学、医学、能源、生物技术和药物发现提供信息，重点关注全球公共卫生问题。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。