PDB Management by the Research Collaboratory for Structural Bioinformatics

新泽西州立大学罗格斯大学（Rutgers University of New Jersey）因管理蛋白质数据库（PDB）而获奖。蛋白质数据库是一个关于生物大分子结构的国际存储库和主要信息来源。PDB是一个关键的研究资源，也是我们理解生命系统的核心组成部分。它为实验、结构和计算科学家以及各级教育工作者提供广泛的服务。PDB访问通过主web和ftp站点（www.pdb.org, ftp.pdb.org）或通过分布在世界各地的多个镜像站点提供。结构生物学研究合作实验室（RCSB）管理PDB的目标是为实验确定的大分子结构提供一个单一的、可搜索的、准确的、注释良好的数据档案。RCSB开发的系统目前用于数据处理、存档、分发和查询，以及物理存档的维护。除了继续运行主要的数据存档、获取和传播功能外，该项目还将对现有基础设施实施若干增强功能。首先，他们将引入与特定用户群体兴趣（如模式生物、蛋白质家族或配体结合位点）相一致的PDB数据视图接口。其次，他们将通过先进的数据格式、元数据标准、软件设计和数据传播，为结构生物学数据的定量表示标准做出贡献。第三，它们将以国际wwPDB伙伴关系的优势为基础，引入综合数据处理框架，提高wwPDB伙伴关系中数据管理的效率和自动化程度。最后，RCSB将继续与不同的社区合作，以确保PDB资源最好地服务于科学、医学和教育的利益。这一努力的结果将是蛋白质数据库对专家和非专业人士的效用和价值的显著提高。增加这项工作更广泛影响的机制包括：一系列研讨会和会议，积极参与科学会议，定期通讯，持续使用帮助台来增加专家和非专业研究界对PDB的访问和效用，以及使用焦点小组来确保PDB数据的最大可用性。参与研究生和本科生课程的设计和实施以及结构化的研究机会正在被用来增加PDB对大学水平教育的影响。参加教师培训讲习班和开展教师发展计划的合作努力为将PDB资源引入K/12教育环境提供了机会。通过巡回艺术展览和频繁的新闻发布和信息节目，公众正在了解人民开发署的努力。像分子解剖计划和分子月这样的在线活动将会吸引全国和全球的观众。总的来说，这些努力将把开发计划署资源和活动的好处扩大到尽可能广泛的社区。

An award is made to Rutgers, the State University of New Jersey to manage the Protein Data Bank (PDB), an international repository and primary source for information about the structure of biological macromolecules. The PDB is a key research resource and a central component to our understanding of living systems. It serves a broad community of experimental, structural and computational scientists, and educators at all levels. PDB access is provided through primary web and ftp sites (www.pdb.org, ftp.pdb.org) or via multiple mirror sites distributed worldwide. The goal of the Research Collaboratory for Structural Biology (RCSB) in managing PDB is to provide a single, searchable archive of accurate and well-annotated data on experimentally determined macromolecular structure. Systems developed by RCSB are currently being used for data processing, archiving, distribution and query, as well as maintenance of the physical archive. In addition to continued operation of the primary data archiving, ingestion, and dissemination functions, the project will implement several enhancements to the existing infrastructure. First, they will introduce view interfaces to the PDB data aligned to specific user community interests such as model organisms, protein families, or ligand binding sites. Second, they will contribute to standards for quantitative representation of structural biology data via advanced data formats, metadata standards, software design, and data dissemination. Third, they will build upon the strengths of the international wwPDB partnership by introducing integrated data processing frameworks to improve efficiency and automation of data curation across the wwPDB partnership. Finally, the RCSB will continue to work with diverse communities to ensure the PDB resource best serves the interest if science, medicine, and education. The result of this effort will be a significant improvement in the utility and value of the Protein Data Bank for both specialists and non-specialists alike. Mechanisms for increasing the broader impacts of this work include the following: a series of workshops and meeting sessions, active participation in scientific meetings, a regular newsletter, the on-going use of a help desk to increase the access and utility of PDB for the specialist and non-specialist research community, and use of focus groups to insure maximum usability of PDB data. Participation in graduate and undergraduate coursework design and implementation and in structured research opportunities is being used to increase the impact of PDB on university-level education. Participation in teacher training workshops and a collaborative effort to launch a teacher development program provide opportunities to bring PDB resources to the K/12 environment. The general public is being made aware of PDB efforts through a traveling art exhibit and through frequent news releases and informational programs. Online-based activities like the Molecular Anatomy Project and Molecule of the Month will reach audiences nationally and globally. Collectively, these efforts will extend the benefits of PDB resources and activities to the broadest possible community.