Controlling the first step of differentiation of embryonic cells
Controlling the first step of differentiation of embryonic cells
批准号:
DP160103651
负责人:
Prof Patrick Tam
金额:
$41.65万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31
中文摘要
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英文摘要
This project aims to improve understanding of how diverse cell types are generated for building the body plan of the embryo. The first step of embryonic cell lineage differentiation takes place at early gastrulation when the multipotent embryonic cells acquire the attributes of specific tissue lineages. This project intends to elucidate how inductive signals and gene function are integrated to drive the lineage choice of the naïve cells, by tracking the impact of the activity of signalling pathways and gene regulation on cell differentiation. This may deliver insights into the temporal hierarchy and functional attributes of the molecular switches that control stem cell differentiation. Expected outcomes may have applications in tissue engineering.
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会议论文
Assembling the building blocks in the blueprint of the embryonic head
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批准号:DP240101571
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项目类别:Discovery Projects
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资助金额:$51.63万
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财政年份:2024
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负责人:Prof Patrick Tam
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依托单位:
Capturing tissue-specific progenitors from embryos and stem cells
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批准号:DP190102793
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项目类别:Discovery Projects
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资助金额:$40.67万
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财政年份:2019
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负责人:Prof Patrick Tam
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依托单位:
Developmental Genomics, Embryology and Stem Cells
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批准号:nhmrc : 1110751
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项目类别:Research Fellowships
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资助金额:$58.74万
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财政年份:2016
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负责人:Prof Patrick Tam
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依托单位:
How to build the head: A molecular mechanistic insight
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批准号:DP160100933
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项目类别:Discovery Projects
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资助金额:$34.09万
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财政年份:2016
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负责人:Prof Patrick Tam
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依托单位:
Developmental Genomics, Embryology and Stem Cells
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批准号:nhmrc : GNT1110751
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项目类别:Research Fellowships
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资助金额:$85.2万
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财政年份:2016
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负责人:Prof Patrick Tam
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依托单位:
Molecular function of the ribonucleic acid binding protein RBM47 in embryonic and mature endoderm cells
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批准号:DP130100779
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项目类别:Discovery Projects
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资助金额:$38.38万
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财政年份:2013
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负责人:Prof Patrick Tam
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依托单位:
A molecular paradigm of organ formation during embryonic development: the role of RhoGTPase
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批准号:DP120100099
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项目类别:Discovery Projects
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资助金额:$21.48万
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财政年份:2012
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负责人:Prof Patrick Tam
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依托单位:
Developmental genetics and stem cell biology of birth defects and cell based therapy
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批准号:nhmrc : 1003100
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项目类别:Research Fellowships
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资助金额:$54.88万
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财政年份:2011
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负责人:Prof Patrick Tam
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依托单位:
Head and face development: dissecting tissue-specific gene function
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批准号:DP1094008
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项目类别:Discovery Projects
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资助金额:$37.78万
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财政年份:2010
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负责人:Prof Patrick Tam
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依托单位:
Multipotent stem cells derived from postimplantation mouse embryos: Evaluation of germ layer differentiation potential
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批准号:nhmrc : 632776
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项目类别:Project Grants
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资助金额:$52.6万
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财政年份:2010
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负责人:Prof Patrick Tam
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依托单位:
Genetic control of body patterning: Intersection of transcriptional and signalling activity in head formation
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批准号:nhmrc : 632777
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项目类别:NHMRC Project Grants
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资助金额:$38.67万
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财政年份:2010
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负责人:Prof Patrick Tam
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依托单位:
Molecular control of embryonic patterning: The function of Rhou gene in mediating response to WNT signalling
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批准号:DP0985052
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项目类别:Discovery Projects
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资助金额:$17.92万
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财政年份:2009
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负责人:Prof Patrick Tam
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依托单位:
Head Morphogenesis and WNT Signalling Function
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批准号:nhmrc : 372103
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项目类别:NHMRC Project Grants
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资助金额:$32.56万
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财政年份:2006
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负责人:Prof Patrick Tam
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依托单位:
Research Fellowship - Grant ID:372102
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批准号:nhmrc : 372102
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项目类别:NHMRC Research Fellowships
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资助金额:$50.09万
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财政年份:2006
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负责人:Prof Patrick Tam
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依托单位:
Detection of Alternative Lengthening of Telomeres in the Mouse
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批准号:nhmrc : 321708
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项目类别:NHMRC Project Grants
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资助金额:$31.41万
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财政年份:2005
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负责人:Prof Patrick Tam
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依托单位:
Head development: Genetic determinants & tissue potency
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批准号:nhmrc : 160909
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项目类别:NHMRC Research Fellowships
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资助金额:$43.29万
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财政年份:2001
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负责人:Prof Patrick Tam
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依托单位:
Head Development: Genetic Determinants and Tissue Potency
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批准号:nhmrc : 138100
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项目类别:NHMRC Project Grants
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资助金额:$63.15万
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财政年份:2001
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负责人:Prof Patrick Tam
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依托单位:
Impact of the extraembryonic tissues on early embryonic development: Genetic basis of abnormal body plan
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批准号:nhmrc : 112900
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项目类别:NHMRC Project Grants
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资助金额:$21.09万
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财政年份:2000
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负责人:Prof Patrick Tam
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依托单位:
Analyzing the pathogenesis of developmental defects in mutant embryos
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批准号:nhmrc : 970775
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项目类别:NHMRC Project Grants
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资助金额:$50.44万
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财政年份:1997
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负责人:Prof Patrick Tam
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依托单位:
国内基金
海外基金
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