Controlling the first step of differentiation of embryonic cells

控制胚胎细胞分化的第一步

• 批准号: DP160103651
• 负责人: Prof Patrick Tam
• 金额: $ 41.65万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160103651
• 关键词: Controlling; first; step; differentiation; embryonic

This project aims to improve understanding of how diverse cell types are generated for building the body plan of the embryo. The first step of embryonic cell lineage differentiation takes place at early gastrulation when the multipotent embryonic cells acquire the attributes of specific tissue lineages. This project intends to elucidate how inductive signals and gene function are integrated to drive the lineage choice of the naïve cells, by tracking the impact of the activity of signalling pathways and gene regulation on cell differentiation. This may deliver insights into the temporal hierarchy and functional attributes of the molecular switches that control stem cell differentiation. Expected outcomes may have applications in tissue engineering.

该项目旨在提高对不同细胞类型如何产生以构建胚胎身体计划的理解。胚胎细胞谱系分化的第一步发生在原肠胚形成早期，多能胚胎细胞获得特定组织谱系的属性。本项目旨在通过跟踪信号通路活性和基因调控对细胞分化的影响，阐明诱导信号和基因功能如何整合以驱动naïve细胞的谱系选择。这可能提供对控制干细胞分化的分子开关的时间层次和功能属性的见解。预期结果可能在组织工程中有应用。