Genetic control of body patterning: Intersection of transcriptional and signalling activity in head formation

身体模式的遗传控制：头部形成中转录和信号活动的交叉点

• 批准号: nhmrc : 632777
• 负责人: Prof Patrick Tam
• 金额: $ 38.67万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genetic-control-body-head-formation/97279
• 关键词: Genetic; control; body; patterning; Intersection

A most critical step in embryonic development is the assembly of the different tissue components into a three-dimensional structure in order to build a major body part of the foetus. The objective of our research is to understand how the mechanisms that control genetic activity and cell-to-cell signalling may cooperate in the formation of the head and face of the embryo. The outcome will focus future clinical investigations to the most relevant genetic determinants of craniofacial defects.

胚胎发育中最关键的一步是将不同的组织成分组装成三维结构，以构建胎儿的主要身体部分。我们研究的目的是了解控制遗传活动和细胞间信号传导的机制如何在胚胎头部和面部的形成中合作。这一结果将使未来的临床研究集中在颅面缺陷最相关的遗传决定因素上。