CAREER: In Silico Tissue Engineering: An Active-Learning Computational Methodology to Guide the Design of Tissue Scaffolds

职业：计算机组织工程：指导组织支架设计的主动学习计算方法

• 批准号: 1350090
• 负责人: Franck Vernerey
• 金额: $ 40万
• 依托单位: University of Colorado at Boulder
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1350090&HistoricalAwards=false
• 关键词: CAREER; Silico; Tissue; Engineering; Active

The objective of this Faculty Early Career Development (CAREER) program award is to construct a computational methodology that can predict, quantify and eventually control the growth mechanisms of engineered tissues based on scaffold design. The approach will enable detailed investigation into the cellular mechanisms responsible for tissue development, enable a real-time integration between model and experiments and finally open the door to the simulation-based design of tissue scaffolds. Research results will also be naturally integrated into a multi-level educational plan to promote the development of simulation-based materials design in Colorado.If successful, this research will enable the design of hydrogel scaffolds that can support the regeneration of damaged tissue from a patient?s own cells. In the long term, such personalized medicine strategies aim to replace tissue and eventually organ transplants. The project will particularly enable: (a) a fundamental insight onto the transport mechanisms and biomechanics driving the growth of engineered cartilage, (b) a novel methodology in which simulations ?actively learn? from experiments in order to optimize their predictive power and (c) a design strategy to control and optimize the scaffold structure in-silico and guide experimental efforts. From an educational viewpoint, this project will also have an impact by exposing K-12 and undergraduate students to simulation-based materials design via interactive teaching modules and the creation of a simulation-based materials design program option and course at CU-Boulder. This effort will be complemented by the organization of a workshop to promote simulation-based materials design and encourage interactions between experimental and modeling materials science research in Colorado.

该学院早期职业发展（CAREER）计划奖项的目标是构建一种计算方法，可以预测、量化并最终控制基于支架设计的工程组织的生长机制。该方法将能够详细研究负责组织发育的细胞机制，实现模型和实验之间的实时集成，并最终为基于模拟的组织支架设计打开大门。研究成果也将自然地融入到多层次的教育计划中，以促进科罗拉多州基于模拟的材料设计的发展。如果成功，这项研究将能够设计水凝胶支架，支持患者自身细胞再生受损组织。从长远来看，这种个性化医疗策略的目标是取代组织移植并最终取代器官移植。该项目将特别实现：（a）对驱动工程软骨生长的运输机制和生物力学的基本见解，（b）一种模拟“主动学习”的新颖方法。通过实验来优化其预测能力，以及（c）一种设计策略来控制和优化计算机支架结构并指导实验工作。从教育角度来看，该项目还将通过交互式教学模块让 K-12 和本科生接触基于模拟的材料设计，并在 CU-Boulder 创建基于模拟的材料设计项目选项和课程，从而产生影响。这项工作将得到组织研讨会的补充，以促进基于模拟的材料设计并鼓励科罗拉多州实验和建模材料科学研究之间的互动。