CAREER: Karrikin and strigolactone signaling mechanisms in Arabidopsis

职业:拟南芥中的 Karrikin 和独脚金内酯信号传导机制

基本信息

  • 批准号:
    1350561
  • 负责人:
  • 金额:
    $ 93.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-02-15 至 2017-04-30
  • 项目状态:
    已结题

项目摘要

DAVID C NELSONPROPOSAL IOS-1350561CAREER: Karrikin and strigolactone signaling mechanisms in ArabidopsisKarrikins are a recently discovered class of compounds found in smoke that activate germination of many plant species after fire. Strigolactones comprise a family of plant hormones that regulate shoot branching, root architecture, and cambial growth. Strigolactones also trigger germination of the highly destructive parasitic weeds, broomrape and witchweed, and promote symbiotic associations with arbuscular mycorrhizal fungi. Understanding the molecular mechanisms by which karrikins and strigolactones control plant growth may enable a new wave of innovation in crop development and weed control.Plants recognize both karrikins and strigolactones through a genetic pathway that requires the F-box protein MAX2. F-box proteins have central roles in several plant hormone signaling systems, and act by targeting specific protein substrates for degradation. The targets of MAX2 have long remained elusive and as such represent a critical roadblock to understanding the mechanism of karrikin and strigolactone signaling. A genetic screen has now led to the identification of a candidate target, SUPPRESSOR OF MAX2 1 (SMAX1), which regulates seed germination and seedling growth. SMAX1 is a member of an uncharacterized family of eight genes in the model plant Arabidopsis thaliana. In this project genetic and biochemical approaches will be used to determine 1) how other genes in the SMAX1 family contribute to plant development; 2) the molecular function and regulation of SMAX1 protein; and 3) the protein interacting partners of SMAX1 and MAX2. These experiments will reveal how the SMAX1 family acts in karrikin and strigolactone signaling and whether SMAX1 is a target of MAX2. A postdoctoral researcher,graduate student, and several undergraduates will be trained for careers in science-related fields. Two projects will be initiated to improve undergraduate retention in science-related careers and enhance K-12 STEM education. The discoveries from this project will be disseminated through publications in peer-reviewed journals and presentations at scientific conferences.
David C NELSONPROPOSAL IOS-1350561CAREER:拟南芥中的Karrikin和Strigolacone信号机制Karrikins是最近发现的一类化合物,在烟雾中发现,它能激活许多植物物种在火灾后的萌发。Strigolactone是一类调节枝条、根构型和形成层生长的植物激素家族。Strigolactone还能激发高度破坏性的寄生杂草、高粱和独脚金的萌发,并促进与丛枝菌根真菌的共生。了解卡瑞金和斯特里内酮控制植物生长的分子机制可能会在作物发展和杂草控制方面带来新一轮的创新。植物通过一条需要F-box蛋白Max2的遗传途径识别卡里金和斯特里内酮。F-box蛋白在几种植物激素信号系统中发挥核心作用,并通过靶向特定的蛋白质底物进行降解。Max2的靶点长期以来一直难以捉摸,因此是理解karrikin和strigolacone信号转导机制的关键障碍。基因筛选现在已经导致了一个候选靶点的确定,即Max2 1抑制因子(SMAX1),它调节种子萌发和幼苗生长。SMAX1是模式植物拟南芥中一个由八个基因组成的未知家族的成员。在这个项目中,将使用遗传和生化方法来确定1)SMAX1家族中的其他基因如何对植物发育做出贡献;2)SMAX1蛋白的分子功能和调控;以及3)SMAX1和Max2的蛋白相互作用伙伴。这些实验将揭示SMAX1家族如何在karrikin和strigolacone信号转导中发挥作用,以及SMAX1是否是Max2的靶标。一名博士后研究员、研究生和几名本科生将接受科学相关领域的职业培训。将启动两个项目,以提高本科生在与科学相关的职业中的留存率,并加强K-12 STEM教育。该项目的发现将通过同行评议期刊上的出版物和在科学会议上的陈述来传播。

项目成果

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David Nelson其他文献

Dimension reduction summaries for balanced contrasts
平衡对比的降维总结
Increasing Student Responsibility and Active Learning in an Undergraduate Capstone Finance Course.
在本科顶点金融课程中增强学生的责任感和主动学习。
Wood Gasification: A Promising Strategy to Extend Fuel Reserves after Global Catastrophic Electricity Loss
木材气化:全球灾难性断电后扩大燃料储备的一项有前景的策略
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
    David Nelson;Alexey Turchin;David Denkenberger
  • 通讯作者:
    David Denkenberger
237 - Associations Between Increased Use of Nondrug and Integrative Modalities and Reduction in Pain and Opioid Dose in Veterans with Chronic Pain and Posttraumatic Stress Disorder
237 - 慢性疼痛和创伤后应激障碍退伍军人中非药物和综合治疗方式使用增加与疼痛减轻和阿片类药物剂量减少之间的关联
  • DOI:
    10.1016/j.jpain.2025.105035
  • 发表时间:
    2025-04-01
  • 期刊:
  • 影响因子:
    4.000
  • 作者:
    Karen Seal;Patrick Hammett;David Nelson;William Becker;Elizabeth Goldsmith;Erin Krebs
  • 通讯作者:
    Erin Krebs
111 Patient, professional and carer experiences of communicating a lung cancer diagnosis: A systematic review of qualitative evidence
  • DOI:
    10.1016/j.lungcan.2024.107672
  • 发表时间:
    2024-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Samuel Cooke;Yordanos Gebre;Jessica Clark;Aslihan Arslan Argin;Ros Kane;Samantha L Quaife;Daisy McInnerney;Lucy Mitchinson;Zara Pogson;Dawn Skinner;Sarah Civello;Ava Harding-Bell;Lynn Calman;Peter Selby;Brian Knowles;Michael D Peake;David Nelson
  • 通讯作者:
    David Nelson

David Nelson的其他文献

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{{ truncateString('David Nelson', 18)}}的其他基金

Investigating Nickel-Catalysed C-P Cross-Coupling
研究镍催化的 C-P 交叉偶联
  • 批准号:
    NE/X00709X/1
  • 财政年份:
    2022
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Research Grant
Collaborative Research: MSA: Tree crown economics: testing and scaling a functional trait-based theory
合作研究:MSA:树冠经济学:测试和扩展基于功能性状的理论
  • 批准号:
    2106058
  • 财政年份:
    2021
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Standard Grant
Collaborative Research: Mechanisms of tree population collapses in eastern North America: Disentangling causes of abrupt ecological change during the Holocene
合作研究:北美东部树木种群崩溃的机制:解开全新世生态突变的原因
  • 批准号:
    1855822
  • 财政年份:
    2019
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Standard Grant
Collaborative Research: Discovery of a negative feedback mechanism that controls karrikin and KAI2 ligand metabolism in plants
合作研究:发现植物中控制 karrikin 和 KAI2 配体代谢的负反馈机制
  • 批准号:
    1856741
  • 财政年份:
    2019
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Standard Grant
Graduate Research Fellowship Program (GRFP)
研究生研究奖学金计划(GRFP)
  • 批准号:
    1840380
  • 财政年份:
    2018
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Fellowship Award
Discovery of a Novel Signal that Enhances Germination and Seedling Growth
发现促进发芽和幼苗生长的新信号
  • 批准号:
    1740560
  • 财政年份:
    2017
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Continuing Grant
Discovery of a Novel Signal that Enhances Germination and Seedling Growth
发现促进发芽和幼苗生长的新信号
  • 批准号:
    1557962
  • 财政年份:
    2016
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Continuing Grant
CAREER: Karrikin and strigolactone signaling mechanisms in Arabidopsis
职业:拟南芥中的 Karrikin 和独脚金内酯信号传导机制
  • 批准号:
    1737153
  • 财政年份:
    2016
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Continuing Grant
Theoretical Problems in Soft Matter and Quantitative Biology
软物质和定量生物学的理论问题
  • 批准号:
    1608501
  • 财政年份:
    2016
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Continuing Grant
Understanding Mechanism and Selectivity in Oxidative Addition to Nickel(0) for Catalytic Cross Coupling
了解镍 (0) 氧化加成催化交叉偶联的机理和选择性
  • 批准号:
    EP/M027678/1
  • 财政年份:
    2015
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Research Grant

相似国自然基金

解析SL和Karrikin信号通路参与植物防御灰霉病的机理研究
  • 批准号:
    2025JJ50121
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目

相似海外基金

Collaborative Research: Discovery of a negative feedback mechanism that controls karrikin and KAI2 ligand metabolism in plants
合作研究:发现植物中控制 karrikin 和 KAI2 配体代谢的负反馈机制
  • 批准号:
    1856741
  • 财政年份:
    2019
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Standard Grant
Collaborative Research: Discovery of a negative feedback mechanism that controls karrikin and KAI2 ligand metabolism in plants
合作研究:发现植物中控制 karrikin 和 KAI2 配体代谢的负反馈机制
  • 批准号:
    1856452
  • 财政年份:
    2019
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Standard Grant
The role of karrikin in regulating photo- and thermomorphogenesis
karrikin 在调节光和热形态发生中的作用
  • 批准号:
    409212330
  • 财政年份:
    2018
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Research Grants
CAREER: Karrikin and strigolactone signaling mechanisms in Arabidopsis
职业:拟南芥中的 Karrikin 和独脚金内酯信号传导机制
  • 批准号:
    1737153
  • 财政年份:
    2016
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Continuing Grant
Understanding the biological functions of the karrikin-responsive signaling system of plants in growth, development and responses to the environment
了解植物 karrikin 响应信号系统在生长、发育和对环境的响应中的生物学功能
  • 批准号:
    DP140104567
  • 财政年份:
    2014
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Discovery Projects
Discovering the molecular mechanisms and origins of karrikin and strigolactone signalling in plants
发现植物中 karrikin 和独脚金内酯信号传导的分子机制和起源
  • 批准号:
    DP130103646
  • 财政年份:
    2013
  • 资助金额:
    $ 93.5万
  • 项目类别:
    Discovery Projects
Diversity in the impact of karrikin signalling on arbuscular mycorrhiza development (A02)
karrikin 信号对丛枝菌根发育影响的多样性 (A02)
  • 批准号:
    518002239
  • 财政年份:
  • 资助金额:
    $ 93.5万
  • 项目类别:
    CRC/Transregios
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