Investigating Nickel-Catalysed C-P Cross-Coupling
研究镍催化的 C-P 交叉偶联
基本信息
- 批准号:NE/X00709X/1
- 负责人:
- 金额:$ 1.65万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2022
- 资助国家:英国
- 起止时间:2022 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
EPSRC : Thomas Kieran Redpath : EP/W522260/1Catalysis is an essential way to speed up chemical reactions and to decrease the energy demands of those reactions (e.g. by decreasing reaction temperatures). Most homogenous catalysis, where the starting materials and catalyst are in the solution phase together, in the pharmaceutical and agrochemical industries requires expensive, rare, and often toxic heavy transition metals such as palladium, platinum, iridium, and rhodium.Nickel is a cheap and abundant metal that can be used to achieve many of the same reactions that palladium and platinum can perform, allowing for more complex materials to be made with greater ease, at lower cost, and more sustainably. Currently, palladium (considered a rare and precious metal) is used to do this in molecules where the desired outcome is the coupling of carbon and phosphorous to form a new bond. Due to the similar reactivity of nickel and palladium in some circumstances, this is something that should be possible with nickel, but for which there are relatively few known examples. The aim of the project is to develop nickel-catalysed reactions that form bonds between carbon and phosphorus, using catalysts with nickel at the centre. The use of ligands, which are groups that attach to the metal catalyst, changes the properties and reactivity of the catalyst; our partners at Dalhousie University (Nova Scotia, Canada) are world experts in ligand design and development and will share their expertise to make our aims a reality. This will enable more cost-effective catalysis in the future for these kinds of chemical transformations.
EPSRC:Thomas Kieran RedPath:EP/W522260/1催化是加速化学反应和降低这些反应的能量需求(例如,通过降低反应温度)的基本方法。大多数均相催化,在制药和农用化学工业中,起始材料和催化剂一起处于溶液相,需要昂贵、稀有且往往有毒的重金属过渡金属,如钯、铂、铱和铑。镍是一种廉价而丰富的金属,可用于实现许多与钯和铂相同的反应,使更复杂的材料能够更容易、更低成本和更可持续地制造出来。目前,钯(被认为是一种稀有而贵重的金属)被用来在分子中做到这一点,其预期的结果是碳和磷耦合形成新的键。由于镍和钯在某些情况下具有相似的反应性,镍应该可以做到这一点,但已知的例子相对较少。该项目的目标是开发镍催化的反应,这些反应在碳和磷之间形成键,使用以镍为中心的催化剂。配体是附着在金属催化剂上的基团,它的使用改变了催化剂的性质和反应活性;我们在达尔豪西大学(加拿大新斯科舍省)的合作伙伴是配体设计和开发方面的世界专家,他们将分享他们的专业知识,以实现我们的目标。这将在未来为这些类型的化学转化提供更具成本效益的催化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David Nelson其他文献
Dimension reduction summaries for balanced contrasts
平衡对比的降维总结
- DOI:
10.1016/j.jspi.2008.04.031 - 发表时间:
2009 - 期刊:
- 影响因子:0.9
- 作者:
David Nelson;S. Noorbaloochi - 通讯作者:
S. Noorbaloochi
Increasing Student Responsibility and Active Learning in an Undergraduate Capstone Finance Course.
在本科顶点金融课程中增强学生的责任感和主动学习。
- DOI:
10.19030/ajbe.v6i2.7692 - 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
David Nelson;C. A. Bianco - 通讯作者:
C. A. Bianco
Wood Gasification: A Promising Strategy to Extend Fuel Reserves after Global Catastrophic Electricity Loss
木材气化:全球灾难性断电后扩大燃料储备的一项有前景的策略
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
David Nelson;Alexey Turchin;David Denkenberger - 通讯作者:
David Denkenberger
237 - Associations Between Increased Use of Nondrug and Integrative Modalities and Reduction in Pain and Opioid Dose in Veterans with Chronic Pain and Posttraumatic Stress Disorder
237 - 慢性疼痛和创伤后应激障碍退伍军人中非药物和综合治疗方式使用增加与疼痛减轻和阿片类药物剂量减少之间的关联
- DOI:
10.1016/j.jpain.2025.105035 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:4.000
- 作者:
Karen Seal;Patrick Hammett;David Nelson;William Becker;Elizabeth Goldsmith;Erin Krebs - 通讯作者:
Erin Krebs
111 Patient, professional and carer experiences of communicating a lung cancer diagnosis: A systematic review of qualitative evidence
- DOI:
10.1016/j.lungcan.2024.107672 - 发表时间:
2024-04-01 - 期刊:
- 影响因子:
- 作者:
Samuel Cooke;Yordanos Gebre;Jessica Clark;Aslihan Arslan Argin;Ros Kane;Samantha L Quaife;Daisy McInnerney;Lucy Mitchinson;Zara Pogson;Dawn Skinner;Sarah Civello;Ava Harding-Bell;Lynn Calman;Peter Selby;Brian Knowles;Michael D Peake;David Nelson - 通讯作者:
David Nelson
David Nelson的其他文献
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{{ truncateString('David Nelson', 18)}}的其他基金
Collaborative Research: MSA: Tree crown economics: testing and scaling a functional trait-based theory
合作研究:MSA:树冠经济学:测试和扩展基于功能性状的理论
- 批准号:
2106058 - 财政年份:2021
- 资助金额:
$ 1.65万 - 项目类别:
Standard Grant
Collaborative Research: Mechanisms of tree population collapses in eastern North America: Disentangling causes of abrupt ecological change during the Holocene
合作研究:北美东部树木种群崩溃的机制:解开全新世生态突变的原因
- 批准号:
1855822 - 财政年份:2019
- 资助金额:
$ 1.65万 - 项目类别:
Standard Grant
Collaborative Research: Discovery of a negative feedback mechanism that controls karrikin and KAI2 ligand metabolism in plants
合作研究:发现植物中控制 karrikin 和 KAI2 配体代谢的负反馈机制
- 批准号:
1856741 - 财政年份:2019
- 资助金额:
$ 1.65万 - 项目类别:
Standard Grant
Graduate Research Fellowship Program (GRFP)
研究生研究奖学金计划(GRFP)
- 批准号:
1840380 - 财政年份:2018
- 资助金额:
$ 1.65万 - 项目类别:
Fellowship Award
Discovery of a Novel Signal that Enhances Germination and Seedling Growth
发现促进发芽和幼苗生长的新信号
- 批准号:
1740560 - 财政年份:2017
- 资助金额:
$ 1.65万 - 项目类别:
Continuing Grant
Discovery of a Novel Signal that Enhances Germination and Seedling Growth
发现促进发芽和幼苗生长的新信号
- 批准号:
1557962 - 财政年份:2016
- 资助金额:
$ 1.65万 - 项目类别:
Continuing Grant
CAREER: Karrikin and strigolactone signaling mechanisms in Arabidopsis
职业:拟南芥中的 Karrikin 和独脚金内酯信号传导机制
- 批准号:
1737153 - 财政年份:2016
- 资助金额:
$ 1.65万 - 项目类别:
Continuing Grant
Theoretical Problems in Soft Matter and Quantitative Biology
软物质和定量生物学的理论问题
- 批准号:
1608501 - 财政年份:2016
- 资助金额:
$ 1.65万 - 项目类别:
Continuing Grant
Understanding Mechanism and Selectivity in Oxidative Addition to Nickel(0) for Catalytic Cross Coupling
了解镍 (0) 氧化加成催化交叉偶联的机理和选择性
- 批准号:
EP/M027678/1 - 财政年份:2015
- 资助金额:
$ 1.65万 - 项目类别:
Research Grant
CAREER: Karrikin and strigolactone signaling mechanisms in Arabidopsis
职业:拟南芥中的 Karrikin 和独脚金内酯信号传导机制
- 批准号:
1350561 - 财政年份:2014
- 资助金额:
$ 1.65万 - 项目类别:
Continuing Grant
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