Investigating Nickel-Catalysed C-P Cross-Coupling

研究镍催化的 C-P 交叉偶联

• 批准号: NE/X00709X/1
• 负责人: David Nelson
• 金额: $ 1.65万
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FX00709X%2F1
• 关键词: Investigating; Nickel; Catalysed; Cross; Coupling

EPSRC : Thomas Kieran Redpath : EP/W522260/1Catalysis is an essential way to speed up chemical reactions and to decrease the energy demands of those reactions (e.g. by decreasing reaction temperatures). Most homogenous catalysis, where the starting materials and catalyst are in the solution phase together, in the pharmaceutical and agrochemical industries requires expensive, rare, and often toxic heavy transition metals such as palladium, platinum, iridium, and rhodium.Nickel is a cheap and abundant metal that can be used to achieve many of the same reactions that palladium and platinum can perform, allowing for more complex materials to be made with greater ease, at lower cost, and more sustainably. Currently, palladium (considered a rare and precious metal) is used to do this in molecules where the desired outcome is the coupling of carbon and phosphorous to form a new bond. Due to the similar reactivity of nickel and palladium in some circumstances, this is something that should be possible with nickel, but for which there are relatively few known examples. The aim of the project is to develop nickel-catalysed reactions that form bonds between carbon and phosphorus, using catalysts with nickel at the centre. The use of ligands, which are groups that attach to the metal catalyst, changes the properties and reactivity of the catalyst; our partners at Dalhousie University (Nova Scotia, Canada) are world experts in ligand design and development and will share their expertise to make our aims a reality. This will enable more cost-effective catalysis in the future for these kinds of chemical transformations.

EPSRC：Thomas Kieran Redpath：EP/W522260/1催化是加速化学反应和减少这些反应的能量需求（例如通过降低反应温度）的重要方法。在制药和农用化学工业中，大多数均相催化（其中起始材料和催化剂一起处于溶液相）需要昂贵、稀有且通常有毒的重过渡金属，例如钯、铂、铱和铑。镍是一种廉价且丰富的金属，可用于实现许多与钯和铂相同的反应，从而可以用更大的成本制造更复杂的材料。 轻松、成本更低、更可持续。目前，钯（被认为是一种稀有贵金属）用于在分子中实现此目的，其中所需的结果是碳和磷偶联形成新的键。由于镍和钯在某些情况下具有相似的反应性，因此镍应该可以做到这一点，但已知的例子相对较少。该项目的目的是开发镍催化反应，使用以镍为中心的催化剂在碳和磷之间形成键。配体（即附着在金属催化剂上的基团）的使用会改变催化剂的性能和反应性；我们在达尔豪斯大学（加拿大新斯科舍省）的合作伙伴是配体设计和开发领域的世界专家，他们将分享他们的专业知识，使我们的目标成为现实。这将为此类化学转化提供更具成本效益的催化。