RUI: Collaborative: unPAK: undergraduates Phenotyping Arabidopsis Knockouts: A distributed genomic approach to examine evolutionarily important traits
RUI:协作:unPAK:本科生拟南芥表型敲除:检查进化重要性状的分布式基因组方法
基本信息
- 批准号:1354771
- 负责人:
- 金额:$ 28.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-06-01 至 2019-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The unPAK (undergraduates Phenotyping Arabidopsis Knockouts) project uses the plant Arabidopsis thaliana to examine how and when differences in DNA sequences lead to differences in traits related to survival, growth, and reproduction. It will detect effects, if any, of mutation in a comprehensive collection of mutants generated by the Salk Institute, and will then compile results in a comprehensive database. To examine the interaction of genetic and environmental effects, unPAK's experiments are replicated within and across multiple growth facilities and labs, and a subset of experiments deliberately manipulate soil factors, moisture, and temperature to see how these important ecological factors interact with genetics. unPAK will survey enough mutant lines to reach coverage of a third of the A. thaliana genome (approximately 9,000 genes). All data will be uploaded into a public database at arabidopsisunpak.org, and this database of observed traits is linked to existing genomic databases. Evidence produced by unPAK will enable testing central hypotheses about the relationship between genomic features and important plant characteristics. For example, the data can be used to test whether the effects of mutation are predicted by gene attributes such as molecular signatures of selection in the past, gene function, gene family size, or by patterns of variability in natural populations.unPAK is centered around participation of undergraduate researchers in the lab and the classroom, educating and training undergraduates integratively in genetics, ecology, evolution, and bioinformatics. The network extends across diverse post-secondary institutions, with over 100 undergraduate apprentices participating across 13 laboratories in 3 years. Greater than 20 course-based undergraduate research experiences (CUREs) will be supported by the program, reaching over 600 students. Any discoveries about the influence of particular genes on fruit production, survival, or life history will have significant broader impacts in potential application to crop species.As a final part of the project the unPAK research network itself is being studied. Using mixed-methods approaches from the social sciences, researchers are documenting interactions among network participants to analyze changes in network structure over time, and to investigate factors that influence student participation and outcomes, including students' accrual of human, cultural, and social capital.
unPAK(本科生拟南芥表型敲出)项目使用拟南芥植物来研究DNA序列的差异如何以及何时导致与生存、生长和繁殖相关的性状差异。它将检测索尔克研究所产生的一系列突变的影响(如果有的话),然后将结果汇编成一个全面的数据库。为了研究遗传和环境影响的相互作用,unPAK的实验在多个生长设施和实验室内和跨实验室重复进行,其中一部分实验故意操纵土壤因素、湿度和温度,以观察这些重要的生态因素如何与遗传相互作用。unPAK将调查足够的突变系,以覆盖拟南芥基因组的三分之一(大约9000个基因)。所有数据将被上传到arabidopsisunpak.org的公共数据库中,这个观察到的特征数据库与现有的基因组数据库相连。unPAK产生的证据将有助于测试基因组特征与重要植物特征之间关系的中心假设。例如,这些数据可以用来测试突变的影响是否可以通过基因属性(如过去选择的分子特征、基因功能、基因家族大小)或自然种群的变异模式来预测。unPAK以本科生研究人员在实验室和课堂上的参与为中心,在遗传学、生态学、进化和生物信息学方面对本科生进行综合教育和培训。该网络扩展到不同的高等教育机构,在3年内有超过100名本科学徒参与了13个实验室。该计划将支持超过20个基于课程的本科研究经验(CUREs),惠及600多名学生。任何关于特定基因对果实生产、生存或生活史影响的发现,都将对作物物种的潜在应用产生重大而广泛的影响。作为该项目的最后一部分,正在研究联合国pak研究网络本身。利用社会科学的混合方法,研究人员正在记录网络参与者之间的互动,以分析网络结构随时间的变化,并调查影响学生参与和结果的因素,包括学生的人力、文化和社会资本的积累。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jennifer Thompson其他文献
Adherens junction breakdown in the periderm following cadmium administration in the chick embryo: distribution of cadherins and associated molecules.
鸡胚施用镉后周皮中的粘附连接破坏:钙粘蛋白和相关分子的分布。
- DOI:
- 发表时间:
2008 - 期刊:
- 影响因子:3.3
- 作者:
Jennifer Thompson;L. Wong;Puong Sing Lau;J. Bannigan - 通讯作者:
J. Bannigan
The Death of the Scholarly Monograph in the Humanities? Citation Patterns in Literary Scholarship
- DOI:
10.1515/libr.2002.121 - 发表时间:
2002 - 期刊:
- 影响因子:0
- 作者:
Jennifer Thompson - 通讯作者:
Jennifer Thompson
Disturbance of SHH signalling pathway during early embryogenesis in the cadmium-induced omphalocele chick model
镉诱导脐膨出雏鸡模型早期胚胎发生过程中SHH信号通路的干扰
- DOI:
10.1007/s00383-012-3193-4 - 发表时间:
2013 - 期刊:
- 影响因子:1.8
- 作者:
N. Fujiwara;Johannes W Duess;P. Puri;Jennifer Thompson - 通讯作者:
Jennifer Thompson
012 – The Building Blocks of Professional Pediatric Nursing Practice
- DOI:
10.1016/j.pedn.2008.11.014 - 发表时间:
2009-04-01 - 期刊:
- 影响因子:
- 作者:
Lezlie Brown-Zoller;Toni Christopherson;Erin Erb;Annie Evans;Donna Greenhalgh;Jessica Holtorf;Patty Schriver;Jennifer Thompson;Erik Zurko - 通讯作者:
Erik Zurko
Impact of Lifestyle Modifications on the Prevention and Treatment of Pelvic Organ Prolapse
- DOI:
10.1007/s00192-024-05992-0 - 发表时间:
2024-11-19 - 期刊:
- 影响因子:1.800
- 作者:
Peter C. Jeppson;Sunil Balgobin;Tom Wheeler;Lori Forner;Delena Caagbay;Jennifer Thompson;Tyler M. Muffly;Isuzu Meyer;Molly Beestrum;Sarah Collins;Vivian Sung - 通讯作者:
Vivian Sung
Jennifer Thompson的其他文献
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{{ truncateString('Jennifer Thompson', 18)}}的其他基金
NIRG: Evaluation of interventions with rare events: methods for parallel cluster randomised trials and stepped-wedge cluster randomised trials
NIRG:罕见事件干预措施的评估:平行整群随机试验和阶梯楔形整群随机试验的方法
- 批准号:
MR/X029492/1 - 财政年份:2024
- 资助金额:
$ 28.7万 - 项目类别:
Research Grant
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