GRK 1870: Bacterial Respiratory Infections - Common and Specific Mechanism of Pathogen Adaption and Immune Defence

GRK 1870：细菌呼吸道感染 - 病原体适应和免疫防御的常见和特定机制

• 批准号: 214214857
• 金额: --
• 依托单位: Universität Greifswald
• 依托单位国家: 德国
• 项目类别: Research Training Groups
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/214214857?language=en
• 关键词: GRK; 1870; Bacterial; Respiratory; Infections

Respiratory tract infections are one of the biggest health threats all over the globe. In this Research Training Group, researchers are engaged to have a scientific insight into three pathogenic organisms namely Streptococcus pneumoniae, Staphylococcus aureus and Burkholderia pseudomallei. Besides being commensals, these microbes have the potential to cause severe respiratory and invasive infections, which are difficult to cure.

呼吸道感染是全球最大的健康威胁之一。在这个研究培训小组中，研究人员致力于对三种致病生物即肺炎链球菌、金黄色葡萄球菌和假马氏伯克氏菌进行科学的了解。除了共生外，这些微生物有可能引起严重的呼吸道感染和侵袭性感染，这些感染很难治愈。

项目成果

Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients

重症监护病房机械通气患者支气管肺泡抽吸物的异质抗菌活性

• DOI: 10.1080/21505594.2019.1682797
• 发表时间: 2019
• 期刊: Virulence
• 影响因子: 5.2
• 作者: Seinen J;Dieperink W;Mekonnen SA;Lisotto P;Harmsen HJM;Hiemstra B;Schultz D;Lalk M;Oswald S;Hammerschmidt S;de Smet AMGA;van Dijl JM
• 通讯作者: van Dijl JM

Impact of Antibiotics with Various Target Sites on the Metabolome of Staphylococcus aureus

• DOI: 10.1128/aac.03104-14
• 发表时间: 2014-12-01
• 期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
• 影响因子: 4.9
• 作者: Doerries, Kirsten;Schlueter, Rabea;Lalk, Michael
• 通讯作者: Lalk, Michael

Thioredoxins and Methionine Sulfoxide Reductases in the Pathophysiology of Pneumococcal Meningitis.

硫氧还蛋白和甲硫氨酸亚硫酸还原酶在肺炎球菌脑膜炎病理生理学中的作用

• DOI: 10.1093/infdis/jiw268
• 发表时间: 2016
• 期刊: The Journal of infectious diseases
• 作者: Ribes S;Abdullah MR;Saleh M;Hanisch UK;Hammerschmidt S
• 通讯作者: Hammerschmidt S

Eicosanoid Profile of Influenza A Virus Infected Pigs

甲型流感病毒感染猪的类二十烷酸谱

• DOI: 10.3390/metabo9070130
• 发表时间: 2019
• 期刊: Metabolites
• 影响因子: 4.1
• 作者: Schultz D;Methling K;KoInfekt Study Group;Rothe M;Lalk M
• 通讯作者: Lalk M

Global spread of mouse-adapted Staphylococcus aureus lineages CC1, CC15, and CC88 among mouse breeding facilities.

适应小鼠的金黄色葡萄球菌谱系 CC1、CC15 和 CC88 在小鼠饲养设施中的全球传播

• DOI: 10.1016/j.ijmm.2017.11.006
• 发表时间: 2018
• 期刊: International journal of medical microbiology : IJMM
• 作者: Mrochen DM;Grumann D;Schulz D;Gumz J;Trübe P;Pritchett-Corning K;Johnson S;Nicklas W;Kirsch P;Martelet K;van den Brandt J;Berg S;Bröker BM;Wiles S;Holtfreter S
• 通讯作者: Holtfreter S