A New Avenue to Promote Lanthanide Ion Emission

促进稀土离子发射的新途径

• 批准号: 1363325
• 负责人: Ana de Bettencourt-Dias
• 金额: $ 41.2万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1363325&HistoricalAwards=false
• 关键词: New; Avenue; Promote; Lanthanide; Ion

In this project, funded by the Chemical Structure, Dynamics and Mechanisms B Program of the Chemistry Division of the National Science Foundation, Professor Ana de Bettencourt-Dias and her research group at the University of Nevada, Reno, decorate the surfaces of diverse nanoparticles with lanthanide ions and assess the ability of these nanoparticles to sensitize lanthanide luminescence. The materials developed have potential application as bioimaging agents. The project involves training of undergraduate and graduate students, as well as postdoctoral researchers, in the synthesis of nanoparticles, organic molecules and lanthanide ion complexes, as well as modern emission and absorption spectroscopic techniques. Student researchers gain experience in writing manuscripts describing their research for publication. To further improve the students' ability to write scientific manuscripts, Prof. de Bettencourt-Dias has developed and will continue improving a course on scientific writing. Topics such as strategies to increase writing productivity, outlining of research manuscripts and graduate theses, the ethics of using published sources and resume writing for job searching in industry are included.Lanthanide ions are light emitters due to transitions within the 4f orbitals. These transitions and the light emission are most easily promoted through coordinated chromophores. As part of this project, the nanoparticle surfaces are functionalized with existing and with new ligands that serve to increase their aqueous solubility and biocompatibility; the ligands also coordinate the lanthanide ions and serve as mediators for the energy transfer. With the help of spectroscopic techniques such as fluorescence, the efficiency of the energy transfer will be assessed and parameters will be developed for improvement of the luminescence properties and for the future use of these decorated nanoparticles in bioimaging applications.

在这个由美国国家科学基金会化学分部化学结构、动力学和机制B项目资助的项目中，内华达大学里诺分校的Ana de Bettencourt-Dias教授和她的研究小组用镧系离子修饰不同纳米颗粒的表面，并评估这些纳米颗粒对镧系发光的敏化能力。所开发的材料作为生物显像剂具有潜在的应用前景。该项目涉及培养纳米粒子、有机分子和镧系离子复合物的合成以及现代发射和吸收光谱技术的本科生、研究生和博士后研究人员。学生研究人员获得撰写手稿的经验，描述他们的研究出版。为了进一步提高学生撰写科学论文的能力，de Bettencourt-Dias教授开发并将继续改进科学写作课程。主题，如提高写作效率的策略，概述研究手稿和研究生论文，使用已发表的资源和简历写作在行业求职的伦理都包括在内。镧系离子由于在4f轨道内的跃迁而发光。这些跃迁和光发射最容易通过协调的发色团来促进。作为该项目的一部分，纳米颗粒表面被现有的和新的配体功能化，以增加其水溶性和生物相容性；配体还协调镧系离子并作为能量转移的介质。在荧光等光谱技术的帮助下，将评估能量转移的效率，并制定参数，以改善发光特性，并为这些修饰纳米颗粒在生物成像应用中的未来使用提供帮助。