A New Avenue to Promote Lanthanide Ion Emission

促进稀土离子发射的新途径

基本信息

批准号：
1363325
负责人：
Ana de Bettencourt-Dias
金额：
$ 41.2万
依托单位：
Board of Regents, NSHE, obo University of Nevada, Reno
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1363325&HistoricalAwards=false
关键词：
New Avenue Promote Lanthanide Ion

项目摘要

In this project, funded by the Chemical Structure, Dynamics and Mechanisms B Program of the Chemistry Division of the National Science Foundation, Professor Ana de Bettencourt-Dias and her research group at the University of Nevada, Reno, decorate the surfaces of diverse nanoparticles with lanthanide ions and assess the ability of these nanoparticles to sensitize lanthanide luminescence. The materials developed have potential application as bioimaging agents. The project involves training of undergraduate and graduate students, as well as postdoctoral researchers, in the synthesis of nanoparticles, organic molecules and lanthanide ion complexes, as well as modern emission and absorption spectroscopic techniques. Student researchers gain experience in writing manuscripts describing their research for publication. To further improve the students' ability to write scientific manuscripts, Prof. de Bettencourt-Dias has developed and will continue improving a course on scientific writing. Topics such as strategies to increase writing productivity, outlining of research manuscripts and graduate theses, the ethics of using published sources and resume writing for job searching in industry are included.Lanthanide ions are light emitters due to transitions within the 4f orbitals. These transitions and the light emission are most easily promoted through coordinated chromophores. As part of this project, the nanoparticle surfaces are functionalized with existing and with new ligands that serve to increase their aqueous solubility and biocompatibility; the ligands also coordinate the lanthanide ions and serve as mediators for the energy transfer. With the help of spectroscopic techniques such as fluorescence, the efficiency of the energy transfer will be assessed and parameters will be developed for improvement of the luminescence properties and for the future use of these decorated nanoparticles in bioimaging applications.

在这个项目中，由国家科学基金会化学部的化学结构，动力学和机制B计划资助，Ana de Bettencourt-Dias教授及其在内华达大学里诺大学的研究小组中，可以通过兰特尼德离子进行多种纳米颗粒的表面，并用兰氏菌离子进行了这些Nanoparticles的能力并评估这些纳米属于lumentemize lanthanidementime lanthanide lanthanide smentimine lanthanide lanthanidementips lanthanide smelinments lanthanide smelitive。开发的材料具有潜在的应用作为生物成像剂。该项目涉及培训本科生和研究生以及博士后研究人员的纳米颗粒，有机分子和灯笼离子离子络合物的合成，以及现代的发射和吸收光谱技术。学生研究人员获得了撰写手稿的经验，描述了他们的出版研究。为了进一步提高学生编写科学手稿的能力，De Bettencourt-Dias教授已经发展了，并将继续改善科学写作课程。包括提高写作生产力的策略，概述研究手稿和研究生论文，使用已发表资料来源的伦理和在行业中进行求职的伦理。这些过渡和光发射最容易通过协调的发色团促进。作为该项目的一部分，纳米颗粒表面与现有的和新的配体一起功能化，可提高其水溶性和生物相容性。配体还协调灯笼离子并充当能量转移的介体。借助光谱技术（例如荧光），将评估能量转移的效率，并将开发参数以改善发光特性，并在未来使用这些装饰的纳米颗粒在生物成像应用中使用。