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Lanthanide Complexes with Concurrent Metal-Centered Emission and Singlet Oxygen Generation

具有同时金属中心发射和单线态氧生成的镧系元素配合物

基本信息

批准号：
1800392
负责人：
Ana de Bettencourt-Dias
金额：
$ 48万
依托单位：
Board of Regents, NSHE, obo University of Nevada, Reno
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2022-11-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1800392&HistoricalAwards=false
关键词：
Lanthanide Complexes Concurrent Metal Centered

项目摘要

In this project, funded by the Chemical Structure, Dynamic & Mechanisms B Program of the Chemistry Division of the National Science Foundation, Professor Ana de Bettencourt-Dias and her research group at the University of Nevada, Reno, are preparing lanthanide ion complexes capable of metal-centered light emission, while at the same time being able to generate singlet oxygen. Their long term goal is to develop new systems that can be used at the same time to image and destroy diseased tissues. This project lies at the interface of organic synthesis, coordination chemistry and spectroscopy. Students of all levels are involved in this research and Professor de Bettencourt-Dias has a track-record of working with a diverse group of undergraduate and graduate students. As part of her commitment to graduate education, she will teach a course in science writing, which has already proven valuable to previous generations of graduate students. Luminescent compounds capable of generating singlet oxygen are potentially interesting for applications requiring cell imaging and cell toxicity, such as photodynamic therapy, thus enabling cancer therapy with simultaneous imaging of the cancerous cells. The light emission ability of the lanthanide ions has been well documented, and here it is proposed to use different types of ligands, based on naphthalimide, pyrene and thiophene-phenyl-thiophene, to not only sensitize the metal-centered luminescence, but also to generate singlet oxygen. The relationships between ligand composition and resulting complex properties will be assessed using absorption, excitation and emission spectroscopy. An additional family of ligands, based on carbazole, which is known for its two-photon absorption capabilities, will be used to isolate heteroleptic complexes and enable low-energy excitation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个项目中，由美国国家科学基金会化学部化学结构、动力学和机制B项目资助，Ana de Bettencourt-Dias教授和她在内华达大学里诺分校的研究小组正在制备能够以金属为中心发光、同时能够产生单线态氧的镧系离子配合物。他们的长期目标是开发可同时用于成像和破坏病变组织的新系统。该项目位于有机合成、配位化学和光谱学的交叉领域。各个级别的学生都参与了这项研究，de Bettencourt-Dias 教授拥有与不同的本科生和研究生群体合作的记录。作为她对研究生教育承诺的一部分，她将教授科学写作课程，这已经被证明对前几代研究生很有价值。能够产生单线态氧的发光化合物对于需要细胞成像和细胞毒性的应用（例如光动力疗法）具有潜在的吸引力，从而使癌症治疗能够同时对癌细胞进行成像。镧系元素离子的发光能力已得到充分证明，这里建议使用基于萘二甲酰亚胺、芘和噻吩-苯基-噻吩的不同类型的配体，不仅可以敏化金属中心发光，而且可以产生单线态氧。将使用吸收光谱、激发光谱和发射光谱来评估配体组成和所得复合物性质之间的关系。另一个基于咔唑的配体家族，以其双光子吸收能力而闻名，将用于分离杂配配合物并实现低能量激发。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Solution structure of a europium–nicotianamine complex supports that phytosiderophores bind lanthanides

铕-烟草胺复合物的溶液结构支持植物铁载体结合镧系元素

DOI：
10.1039/d0cp06150f
发表时间：
2021
期刊：
Physical Chemistry Chemical Physics
影响因子：
3.3
作者：
Kaliakin, Danil S.;Sobrinho, Josiane A.;Monteiro, Jorge H.;de Bettencourt-Dias, Ana;Cantu, David C.
通讯作者：
Cantu, David C.

Synthesis, Structure, Photophysical Properties, and Photostability of Benzodipyrenes

苯并二芘的合成、结构、光物理性质和光稳定性

DOI：
10.1002/chem.201805248
发表时间：
2019
期刊：
Chemistry - A European Journal
影响因子：
0
作者：
Yang, Wenlong;Monteiro, Jorge H.;de Bettencourt-Dias, Ana;Catalano, Vincent J.;Chalifoux, Wesley A.
通讯作者：
Chalifoux, Wesley A.

Azido- and amino-substituted dipicolinates for the sensitization of the luminescent lanthanides EuIII and TbIII

DOI：
10.1016/j.ica.2020.120003
发表时间：
2021
期刊：
Inorganica Chimica Acta
影响因子：
2.8
作者：
Katherine R. Johnson;Ana de Bettencourt-Dias
通讯作者：
Katherine R. Johnson;Ana de Bettencourt-Dias

Metal–organic frameworks of lanthanide iminodiacetates and tartrates: Synthesis, structural characterization and luminescence properties — Commemorating the 100th anniversary of the birth of Academician Guangxian Xu

DOI：
10.1016/j.jre.2021.01.019
发表时间：
2021-02
期刊：
Journal of Rare Earths
影响因子：
4.9
作者：
Melissa Fairley;M. M. V. S. Livera-M.;Wanmin Chen;J. Monteiro;A. Schmitt;Ana de Bettencourt-Dias;S. Robert
通讯作者：
Melissa Fairley;M. M. V. S. Livera-M.;Wanmin Chen;J. Monteiro;A. Schmitt;Ana de Bettencourt-Dias;S. Robert

Thiophene-derivatized pyridine-biscarboxamide as a sensitizer for LnIII luminescence and 1O2 generation