Lanthanide Ion Complexes with Viscosity- or Temperature-dependent Emission

具有粘度或温度依赖性发射的镧系离子配合物

• 批准号: 2155047
• 负责人: Ana de Bettencourt-Dias
• 金额: $ 48.5万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2155047&HistoricalAwards=false
• 关键词: Lanthanide; Ion; Complexes; Viscosity; Temperature

In this project, funded by the Chemical Structure, Dynamics & Mechanisms B and the Chemical Measurement and Imaging Programs of the Chemistry Division of the National Science Foundation, Professor Ana de Bettencourt-Dias and her research group at the University of Nevada, Reno, will isolate lanthanide ion complexes capable of metal-centered light emission. They plan to demonstrate that this light emission can be modulated by viscosity and temperature and they will study the compound design features that best enable this modulation. With the ability to correlate the intensity of the emitted light with the temperature and the viscosity, the group will be able to measure the temperature and viscosity inside of the cells. These properties vary with the type of cell and are important properties to help in the diagnosis of disease and in the unraveling of cell metabolism. The research is also of interest in the management of industrial processes, such as monitoring completion of polymerization and hydrogelation processes. During the project, undergraduate and graduate students as well as postdoctoral scholars will be trained in the synthesis and spectroscopic techniques needed to successfully complete the proposed work. As part of the commitment to support the advancement and inclusivity of underrepresented minority faculty, Professor Ana de Bettencourt-Dias will continue mentoring junior colleagues and promoting their science through a variety of avenues, including, but not limited to, the Periodic TableTalks. Lanthanide ions display sharp emission profile. This emission, which arises from transitions within the 4f orbitals, is most efficiently sensitized through coordinated ligand chromophores. These chromophores can be designed to display an energy transfer to the emissive lanthanide ion, which is modulated by viscosity and temperature. In this project, Professor Ana de Bettencourt-Dias and her research group propose to isolate several new ligands, based on N-heterocycles and cyanovinyl molecular rotors, and to assess their ability to promote metal-ion centered emission as a function of the temperature and viscosity of the medium. In addition, they will study, by using heteroleptic complexes, which ligand functionalities enable the viscosity- and temperature-dependent emission through a two-photon excitation process.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个项目中，由国家科学基金会化学部化学结构、动力学和机理B以及化学测量和成像计划资助，内华达大学雷诺分校的Ana de Bettencourt-Dias教授和她的研究小组将分离能够以金属为中心的光发射的稀土离子络合物。他们计划证明这种光发射可以被粘度和温度调制，他们将研究最能实现这种调制的化合物设计特征。有了将发射光的强度与温度和粘度相关联的能力，该小组将能够测量细胞内部的温度和粘度。这些特性随细胞类型的不同而不同，是帮助诊断疾病和解开细胞新陈代谢的重要特性。这项研究对工业过程的管理也很有兴趣，例如监测聚合和水凝胶过程的完成情况。在项目期间，本科生和研究生以及博士后学者将接受成功完成拟议工作所需的合成和光谱技术方面的培训。作为支持少数族裔教师晋升和包容性承诺的一部分，Ana de Bettencourt-Dias教授将继续指导初级同事，并通过各种途径促进他们的科学，包括但不限于定期TableTalks。镧系元素离子表现出尖锐的发射轮廓。这种由4f轨道内的跃迁引起的发射，通过配位的配位发色团被最有效地敏化。这些生色团可以被设计成显示能量转移到发射的稀土离子，这是由粘度和温度调制的。在这个项目中，Ana de Bettencourt-Dias教授和她的研究小组提议分离几个基于N-杂环和氰基分子转子的新配体，并评估它们促进以金属离子为中心的发射的能力随介质的温度和粘度的变化。此外，他们还将通过使用异感络合物来研究哪些配体的官能团能够通过双光子激发过程实现粘度和温度相关的发射。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。