Epidemiology and clinical implications of the genetic diversity of Echinococcus spp in Sudan, Kenya, Uganda and southern Africa

苏丹、肯尼亚、乌干达和南部非洲棘球蚴属遗传多样性的流行病学和临床意义

• 批准号: 215051603
• 负责人: Professor Dr. Peter Kern
• 金额: --
• 依托单位: Elshaab Medical Teaching Hospital
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/215051603?language=en
• 关键词: Epidemiology; clinical; implications; genetic; diversity

Cystic echinococcosis (CE) is a frequent and economically important zoonosis with a specific impact on disadvantaged pastoralist communities. Therefore, CE is a neglected disease even in high endemicity regions, and is rated by WHO as one of the most important neglected zoonotic diseases (NZD) worldwide. Research objective is (1) to characterize the epidemiological and clinical implications of the genetic diversity of Echinococcus spp. in Sudan, Kenya, Uganda and southern Africa, and (2) to develop molecular tools for application in epidemiology. CE is caused by a highly diverse complex of species, usually assigned to ‘Echinococcus granulosus’. In Africa at least five independent genotypes exist, with highly different biological characteristics, e.g. infectivity to humans. Little data exist on the consequences for public health, livestock production, or control. Recently developed methods will be used to investigate clinical features, public health and economic impact, transmission cycles, host ranges and geographical occurrence of the genotypes. The establishment of a training/support network including the German and African institutions will provide African scientists with molecular, clinical and epidemiological expertise that will enable them to independent studies of CE and other zoonotic diseases. Special emphasis will be placed on the development of ties with institutions in the new state of South Sudan. The project will provide a long-term perspective for and enhancement of cooperative ties which have been developed between the German and African applicants. It will also form the basis for research on the impact of co-infections on the outcome of HIV/AIDS, malaria, tuberculosis and neglected infectious diseases.

囊性棘球蚴病（CE）是一种常见且经济上重要的人畜共患病，对弱势牧民群体有特殊影响。因此，即使在高流行地区，CE也是一种被忽视的疾病，被WHO评为全球最重要的被忽视的人畜共患疾病（NZD）之一。研究目的是：(1)研究苏丹、肯尼亚、乌干达和南部非洲棘球蚴遗传多样性的流行病学和临床意义；(2)开发应用于流行病学的分子工具。CE是由一种高度多样化的物种引起的，通常被归为“细粒棘球绦虫”。在非洲，至少存在五种独立的基因型，它们具有高度不同的生物学特征，例如对人类的传染性。关于对公共卫生、牲畜生产或控制的影响的数据很少。最近开发的方法将用于调查基因型的临床特征、公共卫生和经济影响、传播周期、宿主范围和地理分布。建立一个包括德国和非洲机构在内的培训/支助网络将为非洲科学家提供分子、临床和流行病学专门知识，使他们能够独立研究CE和其他人畜共患疾病。将特别强调发展与南苏丹新国家各机构的关系。该项目将为德国和非洲申请者之间已经发展起来的合作关系提供长期的前景和加强。它还将成为研究合并感染对艾滋病毒/艾滋病、疟疾、结核病和被忽视的传染病结果的影响的基础。