Responsive and Healable Materials Constructed via Dynamic-Covalent Bonds

通过动态共价键构建的响应和可修复材料

• 批准号: 1410223
• 负责人: Brent Sumerlin
• 金额: $ 22.6万
• 依托单位: University of Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1410223&HistoricalAwards=false
• 关键词: Responsive; Healable; Materials; Constructed; via

NON-TECHNICAL SUMMARY: This project will test the hypothesis that dynamic interactions can be used to prepare materials that reversibly assemble and disassemble in solution or in the bulk state. Two specific classes of materials will be considered. The first system will involve nanosized polymeric assemblies that can be triggered to disassemble when high concentrations of sugar are in the surrounding solution. Provided these assemblies can be loaded with molecular cargo, such materials may prove useful for the sugar-induced release of insulin or other therapeutics. The second system to be investigated will consist of bulk plastic or elastomer-like materials capable of healing after being torn, scratched, or broken. Materials that self-heal may find utility in a variety of applications, including being used in medical devices, coatings, and elastomers. Both classes of materials to be studied will derive their adaptability and healability from the design and architectural structure introduced by the synthetic approach in this project. In addition to the development of new materials, studying their underlying chemical and physical properties, and considering the potential utility of these materials, this research will help to educate and train scientists at many levels in a field that is inherently multidisciplinary. TECHNICAL SUMMARY: This research plan is designed to exploit boronic/boronate ester reversibility within the field of responsive polymeric materials. The main hypothesis of the proposed research is that the dynamic-covalent nature of boronic/boronate ester crosslinks can be utilized to achieve stimuli-responsive and self-healing behaviors in two classes of materials. The first class of materials is composed of polymeric vesicles crosslinked via boronic esters. Block copolymers with one hydrophilic block and one boronic acid-containing block will be self-assembled and crosslinked with a multifunctional diol that can be induced to dissociate under high concentrations of sugars and other small molecule diols. The second class of materials to be investigated consists of bulk polymeric materials crosslinked via boronic esters. Upon material failure, healing can be induced by boronic ester exchange at the damage interface. While this phenomenon has been employed for small molecule organic synthesis, molecular recognition, and saccharide sensing, its incorporation in the fields of materials design and controlled polymer synthesis has been significantly limited. Materials that autonomously self-heal may find utility in a variety of applications, including being used in medical devices, coatings, and elastomers. Graduate students involved in this project will gain valuable insight into the emerging fields of reversible-covalent and self-healing materials. Outreach efforts will be a key component of this project and will involve exposure of area high school and community college students to research in these areas.

非技术性总结：本项目将测试动态相互作用可用于制备在溶液或散装状态下可逆组装和分解的材料的假设。将考虑两类特定的材料。第一个系统将涉及纳米级的聚合物组件，当周围溶液中含有高浓度的糖时，这些聚合物组件可以被触发分解。如果这些组件可以装载分子货物，则这些材料可以证明可用于胰岛素或其他治疗剂的糖诱导释放。待研究的第二个系统将由能够在被撕裂、刮擦或破碎后愈合的散装塑料或类似塑料的材料组成。自愈合的材料可用于各种应用，包括用于医疗器械、涂料和弹性体。这两类材料的研究将从设计和建筑结构的综合方法在这个项目中引入他们的适应性和可愈合性。除了开发新材料，研究其潜在的化学和物理特性，并考虑这些材料的潜在效用外，这项研究将有助于在一个固有的多学科领域教育和培训多层次的科学家。 技术总结：本研究计划旨在开发响应性聚合物材料领域内的硼酸酯/硼酸酯可逆性。所提出的研究的主要假设是，可以利用硼酸/硼酸酯交联的动态共价性质来实现两类材料中的刺激响应和自修复行为。第一类材料由通过硼酸酯交联的聚合物囊泡组成。具有一个亲水嵌段和一个含硼酸嵌段的嵌段共聚物将自组装并与多官能二醇交联，所述多官能二醇可在高浓度的糖和其它小分子二醇下被诱导解离。待研究的第二类材料由通过硼酸酯交联的本体聚合物材料组成。在材料失效时，可以通过在损伤界面处的硼酸酯交换来诱导愈合。虽然这种现象已被用于小分子有机合成，分子识别，和糖传感，其在材料设计和受控聚合物合成领域的结合已显着有限。自主自愈的材料可用于各种应用，包括用于医疗器械、涂料和弹性体。参与该项目的研究生将获得对可逆共价和自修复材料新兴领域的宝贵见解。外联工作将是该项目的一个关键组成部分，将涉及地区高中和社区大学学生接触这些领域的研究。