Investigating the Interactions of Ions with Polypeptides

研究离子与多肽的相互作用

基本信息

  • 批准号:
    1413307
  • 负责人:
  • 金额:
    $ 47.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-08-01 至 2017-07-31
  • 项目状态:
    已结题

项目摘要

With support from the Macromolecular, Supramolecular, and Nanochemistry program of the Chemistry Division, Professor Paul S. Cremer at the Pennsylvania State University is exploring the roles that ions play in aqueous solutions containing organic molecules and polymers. Such research can have broad impact as ions influence an enormous variety of processes from allowing molecules to clump together or aggregate, to catalyze processes in cells, and even the length of time it takes to pickle a cucumber. Understanding the pathways that enable proteins to aggregate into particular structures may help reveal the nature of certain human diseases. The behavior of the solutions will be used to create simple demonstration devices as part of an educational outreach effort.Cations and anions in aqueous solvent may interact with each other or with charged groups on small molecules, Langmuir monolayers, and polymer chains. A variety of spectroscopies including infrared, Raman, and vibrational sum frequency generation will be used to investigate how contact pair, solvent shared, and solvent separated ion-ion interactions are affected by the size of the ions, their geometry, their hydrogen bonding ability, van der Waals forces, and the surrounding chemical environment. The molecular level details of these interactions will then be correlated with thermodynamic properties of the corresponding aqueous solutions to understand how ion pairing can influence macroscopic behavior.
在化学系大分子、超分子和纳米化学项目的支持下,宾夕法尼亚州立大学的保罗·S·克里默教授正在探索离子在含有有机分子和聚合物的水溶液中所起的作用。这类研究可以产生广泛的影响,因为离子影响着各种各样的过程,从允许分子聚集在一起,到催化细胞中的过程,甚至是腌制黄瓜所需的时间长度。了解使蛋白质聚集成特定结构的途径可能有助于揭示某些人类疾病的本质。这些溶液的行为将被用来创建简单的演示设备,作为教育推广工作的一部分。水溶液中的阳离子和阴离子可能相互作用,或者与小分子、朗缪尔单分子膜和聚合物链上的带电基团相互作用。包括红外、拉曼和振动和频率产生在内的各种光谱将被用来研究离子-离子相互作用是如何受到离子的大小、它们的几何形状、它们的氢键能力、范德华力和周围化学环境的影响的。这些相互作用的分子水平细节将与相应水溶液的热力学性质相关联,以了解离子配对如何影响宏观行为。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Paul Cremer其他文献

GLIDE Score: A Scoring System for Prediction of Procedural Success in Tricuspid Valve Transcatheter Edge-to-Edge Repair.
GLIDE 评分:用于预测三尖瓣经导管边对边修复手术成功率的评分系统。
  • DOI:
    10.1016/j.jcmg.2024.04.008
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    M. Gerçek;Akhil Narang;M. I. Körber;K. Friedrichs;J. Puthumana;Maria Ivannikova;Mohamed Al;Paul Cremer;Abigail S. Baldridge;Zhiying Meng;P. Luedike;James D. Thomas;T.K. Rudolph;Tobias Geisler;Tienush Rassaf;Roman Pfister;Volker Rudolph;Charles J. Davidson
  • 通讯作者:
    Charles J. Davidson
Feasibility of Non-Invasive Screening for Coronary Allograft Vasculopathy with Positron Emission Tomography Derived Myocardial Blood Flow Assessment
  • DOI:
    10.1016/j.cardfail.2019.07.531
  • 发表时间:
    2019-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Zarina Sharalaya;Andrew Noll;Paul Cremer;Randall C. Starling;W.H. Wilson Tang
  • 通讯作者:
    W.H. Wilson Tang
GENDER SPECIFIC FACTORS ASSOCIATED WITH MAJOR ADVERSE CARDIOVASCULAR EVENTS: INSIGHTS FROM ACCELERATE
  • DOI:
    10.1016/s0735-1097(18)30743-5
  • 发表时间:
    2018-03-10
  • 期刊:
  • 影响因子:
  • 作者:
    Peta King;Paul Cremer;Stephen Nicholls;A. Lincoff;Venu Menon;Jeffrey Riesmeyer;Giacomo Ruotolo;Julie St John;Ellen McErlean;Steven Nissen
  • 通讯作者:
    Steven Nissen
TCT-74 Baseline Left Ventricular Hypertrophy and 5-Year Outcomes after Transcatheter Aortic Valve Replacement: An Analysis of the PARTNER Trials and Registries
  • DOI:
    10.1016/j.jacc.2019.08.112
  • 发表时间:
    2019-10-01
  • 期刊:
  • 影响因子:
  • 作者:
    Holly Gonzales;Pamela Douglas;Philippe Pibarot;Rebecca Hahn;Omar Khalique;Wael Jaber;Paul Cremer;Neil Weissman;Federico Asch;Yiran Zhang;Zachary Gertz;Sammy Elmariah;Marie-Annick Clavel;Vinod Thourani;Melissa Daubert;Maria Alu;Martin Leon;Brian Lindman
  • 通讯作者:
    Brian Lindman
IMPLICATIONS OF WORSENING RIGHT VENTRICULAR FUNCTION FOLLOWING TRANSCATHETER OR SURGICAL AORTIC VALVE REPLACEMENT: INSIGHTS FROM PARTNER2A
  • DOI:
    10.1016/s0735-1097(17)34355-3
  • 发表时间:
    2017-03-21
  • 期刊:
  • 影响因子:
  • 作者:
    Paul Cremer;L. Leonardo Rodriguez;Yiran Zhang;Maria Alu;Brian Lindman;Alan Zajarias;Rebecca Hahn;Stamatios Lerakis;S. Chris Malaisrie;Pamela Douglas;Philippe Pibarot;Lars Svensson;Martin Leon;Wael Jaber
  • 通讯作者:
    Wael Jaber

Paul Cremer的其他文献

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{{ truncateString('Paul Cremer', 18)}}的其他基金

Rules for Ion Pairing in Aqueous Interfacial Structures
水界面结构中离子对的规则
  • 批准号:
    2305129
  • 财政年份:
    2023
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Standard Grant
Collaborative Research: Ion Mobility in Aqueous Acids, Bases, and Salts
合作研究:酸、碱和盐水溶液中的离子淌度
  • 批准号:
    2154651
  • 财政年份:
    2022
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Standard Grant
Hydrophobic and Electrostatic Driving Forces for Ion Adsorption to Polymers and Extended Interfaces
离子吸附到聚合物和扩展界面的疏水和静电驱动力
  • 批准号:
    2004050
  • 财政年份:
    2020
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Standard Grant
PFI-TT: A High-Throughput Instrument for Measuring the Stability of Liquid Formulations of Therapeutic Proteins
PFI-TT:用于测量治疗性蛋白质液体制剂稳定性的高通量仪器
  • 批准号:
    1919083
  • 财政年份:
    2019
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Standard Grant
INFEWS: N/P/H20: From Antinutrients to Water Pollutants: Exploring the Behavior of Polyphosphate Anions in Aqueous Solutions
INFEWS:N/P/H20:从抗营养剂到水污染物:探索多磷酸根阴离子在水溶液中的行为
  • 批准号:
    1709735
  • 财政年份:
    2017
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Continuing Grant
Probing Protein-Salt Interactions with Microfluidics and Nonlinear Optics
利用微流体和非线性光学探测蛋白质-盐相互作用
  • 批准号:
    0809854
  • 财政年份:
    2008
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Continuing Grant
CAREER: The Behavior of Proteins at the Solid-Liquid Interface Monitored in situ with Infrared-Visible Sum Frequency Generation: Investigating the Role of Interfacial Water
职业:利用红外-可见光和频生成原位监测固-液界面蛋白质的行为:研究界面水的作用
  • 批准号:
    0094332
  • 财政年份:
    2001
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Standard Grant
NSF-NATO POSTDOCTORAL FELLOWSHIPS
NSF-北约博士后奖学金
  • 批准号:
    9633841
  • 财政年份:
    1996
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Fellowship Award

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CAREER: Elucidating the Roles of Extracellular Metal Ions in Gut Microbiota Interactions
职业:阐明细胞外金属离子在肠道微生物群相互作用中的作用
  • 批准号:
    2239712
  • 财政年份:
    2023
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Experimental verification of hyperfine interactions using highly charged ions in a low magnetic field
在低磁场中使用高电荷离子进行超精细相互作用的实验验证
  • 批准号:
    22K13990
  • 财政年份:
    2022
  • 资助金额:
    $ 47.51万
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    Grant-in-Aid for Early-Career Scientists
Interactions of Transition Metal Ions with RNA: Structure and Function
过渡金属离子与 RNA 的相互作用:结构和功能
  • 批准号:
    2109255
  • 财政年份:
    2021
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Standard Grant
EAGER: RUI: Elucidation of the AlCl4- and Al2Cl7- ions speciation, interactions and transport in electrolytes comprised of RTILs by Multi-Nuclear NMR techniques.
EAGER:RUI:通过多核 NMR 技术阐明由 RTIL 组成的电解质中 AlCl4- 和 Al2Cl7- 离子的形态、相互作用和传输。
  • 批准号:
    1841398
  • 财政年份:
    2018
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Continuing Grant
Ultracold Molecular Ions Prepared Via Sympathetic Cooling - A New Frontier for Quantum Interactions and Fundamental Physics
通过交感冷却制备超冷分子离子——量子相互作用和基础物理学的新领域
  • 批准号:
    1806288
  • 财政年份:
    2018
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Standard Grant
Electrostatic interactions between multivalent ions and phase separation in charged lipid membranes
多价离子之间的静电相互作用和带电脂质膜中的相分离
  • 批准号:
    17K05610
  • 财政年份:
    2017
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Nucleic acid interactions with partners: ions and proteins
核酸与伙伴的相互作用:离子和蛋白质
  • 批准号:
    10215554
  • 财政年份:
    2017
  • 资助金额:
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Interactions of Transition Metal Ions with RNA: Structure and Function
过渡金属离子与 RNA 的相互作用:结构和功能
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    1710721
  • 财政年份:
    2017
  • 资助金额:
    $ 47.51万
  • 项目类别:
    Standard Grant
Nucleic acid interactions with partners: ions and proteins
核酸与伙伴的相互作用:离子和蛋白质
  • 批准号:
    9918420
  • 财政年份:
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  • 资助金额:
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Chemical Interactions of Metal ions in saliva at the interface with the tooth surface
唾液中金属离子与牙齿表面界面的化学相互作用
  • 批准号:
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  • 财政年份:
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  • 资助金额:
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  • 项目类别:
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