MRI - Head Injury Biomechanics Measurement System

主要研究者：Pfister，Bryan J.提案：1428925职务：MRI -头部损伤生物力学测量系统重要性轻度创伤性脑损伤（TBI）和脑震荡目前是一个主要的公共卫生问题，从青少年活动到专业运动再到日常福尔斯，它们主宰着我们的生活。据估计，仅在美国就发生了160万至380万起与运动有关的脑震荡。虽然有许多研究努力来描述和治疗脑震荡医学，创伤的头部本质上是一个生物力学问题。PI在TBI和爆炸性脑创伤研究方面具有丰富的经验。他们认为，通过仔细进行实验和建模，通过规定正确的几何形状和材料以及初始/边界条件，可以通过指定生物力学边界值问题来定义问题。头部损伤生物力学测量系统将使PI能够控制和测量限制震荡条件的生物力学参数。这项工作将导致制定一个类似于汽车事故头部损伤标准的脑损伤标准（BIC）。这一努力将填补重要的基本知识空白，在目前的创伤性脑震荡injury research.Technical DescriptionThe主要目标的两个PI和中心损伤生物力学，材料和医学（CIBM 3）是提供一个链接外部负荷的头部的空间和时间的应力和应变，造成损伤的大脑。这里提出的头部损伤生物力学测量系统是一个使能组件，它将允许研究人员精确地复制损伤事件，准确地测量多个离散位置的应力和应变，并帮助开发生物力学计算机模型，以建立外部载荷和组织水平应力状态之间的关系。这将是重要的国际研究人员在他们的模型中复制临床相关的生物力学损伤参数，以调查脑震荡injuries.The拟议的头部损伤生物力学测量系统的创伤机制将是一个独特的系统在学术研究界。除了物理假人模型之外，这种使用尸体的独特研究方法将增加开发BIC的临床相关性，并有可能成为该领域的标准。

PI: Pfister, Bryan J.Proposal: 1428925Title: MRI - Head Injury Biomechanics Measurement SystemSignificanceMild traumatic brain injuries (TBI) and concussions are currently a major public health concern that dominates our lives from adolescent activities to professional sports to everyday falls. An estimated 1.6 to 3.8 million sports-related concussions occur in US alone. Though there are many research efforts to describe and treat concussion medically, trauma to the head is essentially a biomechanical problem. The PIs have extensive experience with TBI and blast brain trauma research. They believe that the problem can be defined by specifying the biomechanical boundary value problem through prescribing the right geometry and material and initial/boundary conditions through carefully conducted experiments and modeling. The head injury biomechanics measurement system will enable the PIs to control and measure the biomechanical parameters that bound concussive conditions. This effort will lead in developing a Brain Injury Criterion (BIC) similar to the development of the Head Injury Criterion for automotive accidents. This effort will fill the important fundamental knowledge gap in current traumatic concussive brain injury research.Technical DescriptionThe major goal of both PIs and the Center for Injury Biomechanics, Materials and Medicine (CIBM3) is to provide a link between external loading of the head to the spatial and temporal stress and strains that cause injury to the brain. The Head Injury Biomechanical Measurement System proposed here is an enabling component that will allow researchers to precisely replicate the injury event, accurately measure stresses and strains at multiple discrete locations and help develop bio-fidelic computer models to establish the relationship between external loading and tissue level state of stress. This will be important to researchers internationally to replicate clinically relevant biomechanical injury parameters in their models to investigate the traumatic mechanisms of concussive injury.The proposed Head Injury Biomechanical Measurement System will be a unique system in the academic research community. This unique research approach of using cadavers in addition to physical dummy models will add clinical relevance towards developing a BIC and the potential to be a standard in the field.