MRI: Acquisition of a Zeiss Elyra Super Resolution Microscope for BRC Imaging facility at Cornell

康奈尔大学被授予一项奖项，以支持一种新型光学显微镜的获取和技术管理，该显微镜提供分辨率，以查看和区分小至20纳米，或小于人类头发直径的5000倍的活细胞的特征。这比使用传统光学显微镜所能达到的效果提高了10倍以上。除了为生物和生物医学研究开辟新的途径之外，该仪器还将设在康奈尔成像核心设施，以便它对来自康奈尔内外所有科学研究领域的研究人员和学生开放。由于参与了康奈尔大学的众多外展项目，该成像设施有源源不断的学生通过它。该设施举办教育讲习班，并通过为广泛的外联活动提供参观和示范模块，支持STEM在校园内的倡议。特别是，扩大女性和代表不足的少数族裔在工程和生物技术领域的参与是康奈尔大学的一个主要重点，该设施经常为CATALYST和Expand Your Horizons等项目提供独特的成像实验室模块。收购独特和尖端的超分辨率光学显微镜将使研究生、本科生、当地和来访的高中生能够获得该地区其他地方没有的一种仪器。它将使所有年龄段的学生意识到技术和工程的显著发展，这些技术和工程不断推进成像等领域，并让他们以前所未有的方式看到活细胞的内部工作原理。新获得的显微镜将用于各种研究项目，从细胞生化信号机制的高分辨率研究，到针对改善生物燃料的研究中对纤维素分子结构的调查。例如，它将允许绘制和量化调控转录的蛋白质和被转录的基因之间的空间、时间和功能关系。超分辨率显微镜领域还处于初级阶段，光学超分辨率的新的重要应用正在以惊人的速度在生命科学的所有领域得到展示。康奈尔大学拥有高水平的显微镜和生物成像经验以及特别广泛的应用曲目，因此是安装这样的仪器的理想地点。康奈尔大学提供的广泛的显微镜专业知识将导致生物成像方面的协同进步，并通过开发为研究人员的特定应用量身定做的新方法来扩展新兴的超分辨率显微镜领域。这种类型的协同作用将转化为使用该工具进行的研究可能产生的最重大和最广泛的影响，并随着结果的公布和新技术的广泛应用，最终促进不同领域的知识库和理解。

An award is made to Cornell University to support the acquisition and technical management of a new type of light microscope that provides the resolution to see and differentiate features in living cells as small as 20 nm, or 5000 times smaller than the diameter of a human hair. This is more than a 10 fold improvement over what is achievable using a conventional light microscope. In addition to enabling new avenues of biological and biomedical research that are now impossible without it, the instrument will be located in the Cornell Imaging Core Facility so that it is open and available to investigators and students from all areas of scientific research inside and outside of Cornell. The imaging facility has a steady flow of students passing through it due to its participation in the numerous outreach programs occurring at Cornell. The facility hosts educational workshops and supports STEM initiatives on campus by providing tours and demonstration modules for a wide range of outreach activities. In particular, broadening the participation of women and under-represented minorities in engineering and biotechnology is a major focus at Cornell, and the facility routinely offers unique imaging laboratory modules for programs such as CATALYST and Expand Your Horizons. The acquisition of a unique and cutting edge super-resolution light microscope will provide graduate, undergraduate and local and visiting high school students with access to a type of instrument not available anywhere else in the region. It will make students of all ages aware of the remarkable developments in technology and engineering that are continually advancing fields such as imaging, and let them see the inner workings of living cells in ways that no one has ever before seen.The newly acquired microscope will be used in variety of research projects ranging from high resolution studies of the cellular biochemical signaling machinery, to investigations into the molecular structure of cellulose in research directed at improving biofuels. It will allow for the spatial, temporal and functional relationships between, for example, proteins that regulate transcription and the gene being transcribed to be mapped and quantified. The field of super-resolution microscopy is in its infancy and new and important applications of optical super-resolution are being demonstrated in all areas of the life sciences at a remarkable rate. Cornell has a high level of microscopy and biological imaging experience and a particularly broad repertoire of applications, and as such, is an ideal site for an instrument such as this to be located. The extensive microscopy expertise available at Cornell will lead to synergistic advances in biological imaging and extend the emerging field of super resolution microscopy through the development of new methodologies tailored for the specific applications of the investigators. This type of synergy will translate into the most significant and broadest possible impact of the research carried out using the instrument, and ultimately advance the knowledge base and understanding across diverse fields as the results are published and new technology broadly utilized.