MRI: Acquisition of a Zeiss Elyra Super Resolution Microscope for BRC Imaging facility at Cornell

康奈尔大学获得了一项奖励，以支持一种新型光学显微镜的收购和技术管理，该显微镜提供了观察和区分活细胞中小至20 nm或比人类头发直径小5000倍的特征的分辨率。这比使用传统光学显微镜所能实现的提高了10倍以上。 除了使生物和生物医学研究的新途径，现在没有它是不可能的，该仪器将位于康奈尔成像核心设施，使它是开放的，并提供给来自康奈尔内外科学研究的所有领域的研究人员和学生。 该成像设施有一个稳定的学生流通过它，由于它在康奈尔大学发生的众多外展计划的参与。 该设施举办教育研讨会，并通过为广泛的外展活动提供图尔斯和演示模块来支持校园内的STEM举措。特别是，扩大妇女和代表性不足的少数民族在工程和生物技术的参与是康奈尔大学的一个主要重点，该设施经常为CATALYST和Expand Your Horizons等项目提供独特的成像实验室模块。收购一个独特的和先进的超分辨率光学显微镜将提供研究生，本科生和当地和访问高中学生获得一种类型的仪器没有在该地区的其他地方。 它将使各个年龄段的学生了解技术和工程学的显著发展，这些技术和工程学正在不断推进成像等领域，并让他们以前所未有的方式看到活细胞的内部运作。新获得的显微镜将用于各种研究项目，从细胞生化信号机制的高分辨率研究，涉及在旨在改进生物燃料的研究中对纤维素分子结构的研究。它将允许例如调节转录的蛋白质和被转录的基因之间的空间、时间和功能关系被映射和量化。超分辨率显微镜领域正处于起步阶段，光学超分辨率的新的和重要的应用正在以惊人的速度在生命科学的所有领域中得到证明。 康奈尔大学拥有高水平的显微镜和生物成像经验，以及特别广泛的应用程序，因此，是一个理想的网站，如要找到这样的仪器。 康奈尔大学提供的广泛的显微镜专业知识将导致生物成像的协同进步，并通过为研究人员的具体应用开发量身定制的新方法来扩展超分辨率显微镜的新兴领域。 这种类型的协同作用将转化为使用该工具进行的研究的最重要和最广泛的影响，并最终随着结果的发表和新技术的广泛使用，推进知识基础和对不同领域的理解。

An award is made to Cornell University to support the acquisition and technical management of a new type of light microscope that provides the resolution to see and differentiate features in living cells as small as 20 nm, or 5000 times smaller than the diameter of a human hair. This is more than a 10 fold improvement over what is achievable using a conventional light microscope. In addition to enabling new avenues of biological and biomedical research that are now impossible without it, the instrument will be located in the Cornell Imaging Core Facility so that it is open and available to investigators and students from all areas of scientific research inside and outside of Cornell. The imaging facility has a steady flow of students passing through it due to its participation in the numerous outreach programs occurring at Cornell. The facility hosts educational workshops and supports STEM initiatives on campus by providing tours and demonstration modules for a wide range of outreach activities. In particular, broadening the participation of women and under-represented minorities in engineering and biotechnology is a major focus at Cornell, and the facility routinely offers unique imaging laboratory modules for programs such as CATALYST and Expand Your Horizons. The acquisition of a unique and cutting edge super-resolution light microscope will provide graduate, undergraduate and local and visiting high school students with access to a type of instrument not available anywhere else in the region. It will make students of all ages aware of the remarkable developments in technology and engineering that are continually advancing fields such as imaging, and let them see the inner workings of living cells in ways that no one has ever before seen.The newly acquired microscope will be used in variety of research projects ranging from high resolution studies of the cellular biochemical signaling machinery, to investigations into the molecular structure of cellulose in research directed at improving biofuels. It will allow for the spatial, temporal and functional relationships between, for example, proteins that regulate transcription and the gene being transcribed to be mapped and quantified. The field of super-resolution microscopy is in its infancy and new and important applications of optical super-resolution are being demonstrated in all areas of the life sciences at a remarkable rate. Cornell has a high level of microscopy and biological imaging experience and a particularly broad repertoire of applications, and as such, is an ideal site for an instrument such as this to be located. The extensive microscopy expertise available at Cornell will lead to synergistic advances in biological imaging and extend the emerging field of super resolution microscopy through the development of new methodologies tailored for the specific applications of the investigators. This type of synergy will translate into the most significant and broadest possible impact of the research carried out using the instrument, and ultimately advance the knowledge base and understanding across diverse fields as the results are published and new technology broadly utilized.